{{Rsnum
|rsid=1049296
|Gene=TF
|Chromosome=3
|position=133775510
|Orientation=plus
|GMAF=0.1488
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=TF
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 74.3 | 23.9 | 1.8
| HCB | 56.9 | 34.3 | 8.8
| JPT | 59.3 | 33.6 | 7.1
| YRI | 89.8 | 10.2 | 0.0
| ASW | 82.5 | 15.8 | 1.8
| CHB | 56.9 | 34.3 | 8.8
| CHD | 56.9 | 37.6 | 5.5
| GIH | 63.4 | 33.7 | 3.0
| LWK | 84.5 | 15.5 | 0.0
| MEX | 74.1 | 25.9 | 0.0
| MKK | 60.3 | 37.8 | 1.9
| TSI | 70.6 | 27.5 | 2.0
| HapMapRevision=28
}}{{PMID Auto
|PMID=20029940
|Title=Suggestive synergy between genetic variants in TF and HFE as risk factors for Alzheimer's disease
|OA=1
}}

{{omim
|id=190000
|rsnum=1049296
|variant=0004
}}

{{PMID Auto GWAS
|PMID=21665994
|Trait=None
|Title=Genome-wide association study identifies two loci strongly affecting transferrin glycosylation.
|RiskAllele=T
|Pval=5E-43
|OR=0.2900
|ORtxt=[0.25-0.33] unit decrease
|OA=1
}}

{{ClinVar
|rsid=1049296
|Reversed=0
|FwdREF=C
|FwdALT=T
|REF=C
|ALT=T
|RSPOS=133494354
|CHROM=3
|GMAF=0.1488
|dbSNPBuildID=86
|SSR=0
|SAO=1
|VP=0x05036800000015051f130101
|GENEINFO=TF:7018
|GENE_NAME=TF
|GENE_ID=7018
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000003.11:g.133494354C>T
|CLNORIGIN=1
|CLNSIG=255
|Tags=PM;PMC;S3D;SLO;VLD;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;MTP;OM
|CAF=0.8512; 0.1488
|CLNACC=RCV000013451.21; RCV000013452.1
|CLNDBN=Transferrin variant c1/c2; Alzheimer disease, susceptibility to
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=190000.0004
|COMMON=1
|Disease=Transferrin variant c1/c2; Alzheimer disease
}}

{{PMID Auto
|PMID=17357082
|Title=Identification of a novel risk locus for progressive supranuclear palsy by a pooled genomewide scan of 500,288 single-nucleotide polymorphisms.
|OA=1
}}

{{PMID Auto
|PMID=17601350
|Title=A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.
|OA=1
}}

{{PMID Auto
|PMID=18795173
|Title=Variants in iron metabolism genes predict higher blood lead levels in young children.
|OA=1
}}

{{PMID Auto
|PMID=18813964
|Title=Alzheimer's disease risk variants show association with cerebrospinal fluid amyloid beta.
|OA=1
}}

{{PMID Auto
|PMID=18830724
|Title=Assessment of Alzheimer's disease case-control associations using family-based methods.
|OA=1
}}

{{PMID Auto
|PMID=19084216
|Title=Association of genetic variants at 3q22 with nephropathy in patients with type 1 diabetes mellitus.
|OA=1
}}

{{PMID Auto
|PMID=19165391
|Title=Iron metabolism genes, low-level lead exposure, and QT interval.
|OA=1
}}

{{PMID Auto
|PMID=19673882
|Title=A novel association between a SNP in CYBRD1 and serum ferritin levels in a cohort study of HFE hereditary haemochromatosis.
|OA=1
}}

{{PMID Auto
|PMID=20574532
|Title=Intermediate phenotypes identify divergent pathways to Alzheimer's disease.
|OA=1
}}

{{PMID Auto
|PMID=20659343
|Title=HFE gene variants modify the association between maternal lead burden and infant birthweight: a prospective birth cohort study in Mexico City, Mexico.
|OA=1
}}

{{GET Evidence
|gene=TF
|aa_change=Pro589Ser
|aa_change_short=P589S
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1049296
|overall_frequency_n=1421
|overall_frequency_d=10758
|overall_frequency=0.132088
|n_genomes=16
|n_genomes_annotated=0
|n_haplomes=19
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.011
|nblosum100=3
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=23732512
|Title=Effect modification by transferrin C2 polymorphism on lead exposure, hemoglobin levels, and IQ.
}}

{{PMID Auto
|PMID=24121126
|Title=Pooled analysis of iron-related genes in Parkinson's disease: association with transferrin
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}