{{Rsnum
|rsid=10492972
|Gene=KIF1B
|Chromosome=1
|position=10293054
|Orientation=plus
|GMAF=0.3512
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=KIF1B
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 11.5 | 44.2 | 44.2
| HCB | 10.9 | 48.9 | 40.1
| JPT | 17.7 | 36.3 | 46.0
| YRI | 10.9 | 44.9 | 44.2
| ASW | 7.0 | 35.1 | 57.9
| CHB | 10.9 | 48.9 | 40.1
| CHD | 10.1 | 54.1 | 35.8
| GIH | 9.9 | 37.6 | 52.5
| LWK | 15.5 | 38.2 | 46.4
| MEX | 17.2 | 46.6 | 36.2
| MKK | 10.3 | 41.7 | 48.1
| TSI | 15.7 | 38.2 | 46.1
| HapMapRevision=28
}}[[rs10492972]] is a SNP in the [[KIF1B]] gene, which encodes a neuroprotein.

A genome-wide association study of 2,679 patients with [[multiple sclerosis]] (and 3,000+ controls) concluded that the [[rs10492972]](C) allele is a risk allele for the disease, with an odds ratio of 1.35 (p = 2.5 x 10e-10). This is one of the few SNPs associated with [[multiple sclerosis]] that is not related to immune function. {{PMID|18997785}}

A 2011 report combining eight data sets of cases and controls and three independent data sets of the International Multiple Sclerosis Genetic Consortium excluded the [[rs10492972]](C) allele as a major "risk" allele for MS with a high degree of confidence (p = 1.18 × 10e-4), i.e. they say it's not a risk allele.{{PMID|21594895|OA=1
}}

{{omim
|desc=MULTIPLE SCLEROSIS, SUSCEPTIBILITY TO, 4; MS4
|id=612596
|rsnum=10492972
}}

{{PharmGKB
|RSID=rs10492972
|Name_s=
|Gene_s=KIF1B
|Feature=
|Evidence=PubMed ID:18997785; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis. (Initial Sample Size: 45 cases, 195 controls; Replication Sample Size: 2,634 cases, 2,930 controls); (Region: 1p36.22; Reported Gene(s): KIF1B; Risk Allele: rs10492972-C); (p-value= 0.0000000003).This variant is associated with Multiple sclerosis.
|Drugs=
|Drug Classes=
|Diseases=Multiple Sclerosis
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740742
}}
{{PMID Auto
|PMID=20067515
|Title=Lack of replication of KIF1B gene in an Italian primary progressive multiple sclerosis cohort
}}

{{PharmGKB
|RSID=rs10492972
|Name_s=
|Gene_s=KIF1B
|Feature=
|Evidence=PubMed ID:18997785
|Annotation=In a GWAS this rs10492972[C] variant located in the KIF1B gene was associated with multiple sclerosis.
|Drugs=
|Drug Classes=
|Diseases=Multiple Sclerosis
|Curation Level=Curated
|PharmGKB Accession ID=PA162360096
}}

{{PMID Auto
|PMID=21680216
|Title=Polymorphic locus rs10492972 of the KIF1B gene association with multiple sclerosis in Russia: Case control study
}}

{{PMID|19361613|OA=1
}} Genetic control of human brain transcript expression in Alzheimer disease.

{{PMID|19525953|OA=1
}} Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.

{{PMID|20502484|OA=1
}} Lack of support for association between the KIF1B rs10492972[C] variant and multiple sclerosis.

{{PMID|21304891|OA=1
}} A study of CNVs as trait-associated polymorphisms and as expression quantitative trait loci.

{{PMID|21424745}} The rs10492972 KIF1B polymorphism and disease progression in Greek patients with multiple sclerosis.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10492972
|overall_frequency_n=42
|overall_frequency_d=126
|overall_frequency=0.333333
|n_genomes=28
|n_genomes_annotated=0
|n_haplomes=35
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}