{{Rsnum
|rsid=1049331
|Gene=HTRA1
|Chromosome=10
|position=122461754
|Orientation=plus
|ReferenceAllele=C
|GMAF=0.2916
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=HTRA1
}}{{PMID|18316707|OA=1
}} 
*[[rs11200638]] 1.7x10-14 (-625G>A)is the most significant associated SNP with a high OR of 7.6 (95%CI: 3.94-14.51) 
*[[rs2672598]] 3.0x10-10 (-487T>C)
*[[rs1049331]] 3.7x10-12 (102C>T, Ala34Ala)
*[[rs2293870]] 3.7x10-12 (108G>T, Gly36Gly) 
*haplotype ACCTT, significantly predisposes to AMD (p= 6.68x10-14)
*[[smoking]] and [[rs800292]] (184G>A, Val62Ile) of CFH.
*The combined OR for disease of smoking and [[rs11200638]] (HTRA1) caused a 15.7 fold increased risk 
*The combined OR for [[rs800292]] and [[rs11200638]] showed a 23.3 fold increased risk
*An extremely high population attributable risk (PAR) of 78% was also found.
{{ neighbor
| rsid = 2672598
| distance = 588
}}
{{ neighbor
| rsid = 2293870
| distance = 6
}}
{{PMID Auto
|PMID=19796758
|Title=Comprehensive Analysis of Complement Factor H and LOC387715/ARMS2/HTRA1 Variants with Respect to Phenotype in Advanced Age-related Macular Degeneration
|OA=1
}}{{ClinVar
|rsid=1049331
|Reversed=0
|FwdREF=C
|FwdALT=T
|REF=C
|ALT=T
|RSPOS=124221270
|CHROM=10
|GMAF=0.2917
|dbSNPBuildID=86
|SSR=0
|SAO=0
|VP=0x050168000000140116100100
|GENEINFO=HTRA1:5654
|GENE_NAME=HTRA1
|GENE_ID=5654
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000010.10:g.124221270C>T
|CLNSRC=GeneReviews
|CLNSRCID=NBK32533
|CLNSIG=2
|CLNCUI=C1838577
|CLNDBN=Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy
|Disease=Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy
|CLNACC=RCV000020489.1
|Tags=PM;PMC;SLO;VLD;GNO;KGPhase1;KGPROD;OTHERKG;LSD
|CAF=0.7084; 0.2916
|CLNDSDB=GeneReviews:MedGen:OMIM:Orphanet
|CLNDSDBID=NBK32533:C1838577:600142:199354
|COMMON=1
}}{{PMID Auto
|PMID=19026761
|Title=Molecular pathology of age-related macular degeneration.
|OA=1
}}

{{PMID Auto
|PMID=20140183
|Title=Genetic and functional dissection of HTRA1 and LOC387715 in age-related macular degeneration.
|OA=1
}}
{{PMID Auto
|PMID=23644223
|Title=Variants at chromosome 10q26 locus and the expression of HTRA1 in the retina
}}
{{PMID Auto
|PMID=24013816
|Title=Cumulative association between age-related macular degeneration and less studied genetic variants in PLEKHA1/ARMS2/HTRA1: a meta and gene-cluster analysis
}}