{{Rsnum
|rsid=1049353
|Gene=CNR1
|Chromosome=6
|position=88143916
|Orientation=plus
|GMAF=0.1373
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=CNR1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 4.5 | 37.5 | 58.0
| HCB | 0.0 | 15.3 | 84.7
| JPT | 0.0 | 14.4 | 85.6
| YRI | 0.0 | 3.4 | 96.6
| ASW | 0.0 | 17.5 | 82.5
| CHB | 0.0 | 15.3 | 84.7
| CHD | 0.0 | 12.8 | 87.2
| GIH | 6.9 | 27.7 | 65.3
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 17.2 | 82.8
| MKK | 0.0 | 1.3 | 98.7
| TSI | 4.0 | 32.0 | 64.0
| HapMapRevision=28
}}
Based on a study of 256 Caucasian patients being treated for [[depression]], carriers of a [[rs1049353]](G) allele were less likely to respond favorably, particularly if they were females with comorbid anxiety.{{PMID|18579347}}

{{PMID Auto
|PMID=19443135
|Title=The association between cannabinoid receptor 1 gene (CNR1) and cannabis dependence symptoms in adolescents and young adults
|OA=1
}}

{{PMID Auto
|PMID=20195480
|Title=The Cannabinoid 1 Receptor (CNR1) 1359 G/A Polymorphism Modulates Susceptibility to Ulcerative Colitis and the Phenotype in Crohn's Disease
|OA=1
}}

[[rs806368]](C) together with rs1049353(A) or rs1049353(G) make up a haplotype associated with [[PTSD]], with the C-A haplotype somewhat associated (p=0.04) with higher risk of [[PTSD]] and the C-G haplotype associated (p=0.01) with a lower risk of [[PTSD]]. {{PMID|18213623|OA=1
}}

{{PMID Auto
|PMID=20587580
|Title=Polymorphisms in the endocannabinoid-receptor 1 in relation to fat mass distribution
}}

{{PMID Auto
|PMID=21892520
|Title=The association of the rs1049353 polymorphism of the CNR1 gene with hypoadiponectinemia
}}

{{PMID Auto
|PMID=22085192
|Title=Cannabinoid Receptor 1 Gene is Associated with Alcohol Dependence
}}

{{PMID|16917946|OA=1
}} Cannabis receptor haplotype associated with fewer cannabis dependence symptoms in adolescents.

{{PMID|17292652}} No evidence for an involvement of variants in the cannabinoid receptor gene (CNR1) in obesity in German children and adolescents.

{{PMID|17873324}} The G1422A variant of the cannabinoid receptor gene (CNR1) is associated with abdominal adiposity in obese men.

{{PMID|17881126}} No association of CNR1 gene variations with susceptibility to schizophrenia.

{{PMID|17942526}} Polymorphisms of the cannabinoid 1 receptor gene and cognitive impairment in multiple sclerosis.

{{PMID|18179391}} Association between single nucleotide polymorphisms in the cannabinoid receptor gene (CNR1) and impulsivity in southwest California Indians.

{{PMID|18606954|OA=1
}} Cannabinoid receptor 1 gene association with nicotine dependence.

{{PMID|18776593|OA=1
}} Cannabinoid type-1 receptor gene polymorphisms are associated with central obesity in a Southern Brazilian population.

{{PMID|19014633|OA=1
}} Lack of association of genetic variants in genes of the endocannabinoid system with anorexia nervosa.

{{PMID|19016476|OA=1
}} Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence.

{{PMID|19018721|OA=1
}} Genetic variation in cannabinoid receptor 1 (CNR1) is associated with derangements in lipid homeostasis, independent of body mass index.

{{PMID|19052543|OA=1
}} Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample.

{{PMID|19093002|OA=1
}} CB1 expression is attenuated in Fallopian tube and decidua of women with ectopic pregnancy.

{{PMID|19335651|OA=1
}} Candidate genes for cannabis use disorders: findings, challenges and directions.

{{PMID|19659925}} Association of CNR1 and FAAH endocannabinoid gene polymorphisms with anorexia nervosa and bulimia nervosa: evidence for synergistic effects.

{{PMID|19886064}} The implication of CNR1 gene's polymorphisms in the modulation of endocannabinoid system effects.

{{PMID|20033240|OA=1
}} Eating disorders: the current status of molecular genetic research.

{{PMID|20080186}} Investigation of CNR1 and FAAH endocannabinoid gene polymorphisms in bipolar disorder and major depression.

{{PMID|20192949}} CNR1 gene polymorphisms in addictive disorders: a systematic review and a meta-analysis.

{{PMID|20204253}} G1359A polymorphism of the cannabinoid receptor gene (CNR1) and insulin resistance in patients with diabetes mellitus type 2.

{{PMID|20415562}} Role of genetic variation in the cannabinoid type 1 receptor gene (CNR1) in the pathophysiology of human obesity.

{{PMID|20631561}} Endocannabinoid Pro129Thr FAAH functional polymorphism but not 1359G/A CNR1 polymorphism is associated with antipsychotic-induced weight gain.

{{PMID|20838400}} Are endocannabinoid type 1 receptor gene (CNR1) polymorphisms associated with obesity and metabolic syndrome in postmenopausal Polish women?

{{PMID|21129839}} A common variation in the cannabinoid 1 receptor (CNR1) gene is associated with pre-eclampsia in the Central European population.

{{PMID|21695734}} Cannabinoid type 1 receptor gene polymorphisms are not associated with olanzapine-induced weight gain.

{{PMID|22393204|OA=1
}} Cannabinoid Receptor Genotype Moderation of the Effects of Childhood Physical Abuse on Anhedonia and Depression.

{{PMID Auto
|PMID=22194214
|Title=Replication study of 10 genes showing evidence for association with multiple sclerosis: validation of TMEM39A, IL12B and CBLB [correction of CLBL] genes
}}

{{PMID Auto
|PMID=22826533
|Title=Genetic variability in the endocannabinoid system and 12-week clinical response to citalopram treatment: the role of the CNR1, CNR2 and FAAH genes
}}

{{PMID Auto
|PMID=23372171
|Title=Elevated Anandamide and Related N-Acylethanolamine Levels Occur in the Peripheral Blood of Women With Ectopic Pregnancy and Are Mirrored by Changes in Peripheral Fatty Acid Amide Hydrolase Activity
}}

{{PMID Auto
|PMID=24322329
|Title=Role of Genetic Variation in the Cannabinoid Receptor Gene (CNR1) (G1359A Polymorphism) on Weight Loss and Cardiovascular Risk Factors After Liraglutide Treatment in Obese Patients With Diabetes Mellitus Type 2
}}

{{PMID Auto
|PMID=24407958
|Title=Risky alcohol consumption in young people is associated with the fatty acid amide hydrolase gene polymorphism C385A and affective rating of drug pictures
}}

{{PMID Auto
|PMID=22920733
|Title=Investigation of endocannabinoid system genes suggests association between peroxisome proliferator activator receptor-alpha gene (PPARA) and schizophrenia.
}}

{{PMID Auto
|PMID=23010766
|Title=Failure to extinguish fear and genetic variability in the human cannabinoid receptor 1.
|OA=1
}}

{{PMID Auto
|PMID=23337343
|Title=Genetic variation in the cannabinoid receptor gene (CNR1) (G1359A polymorphism) and their influence on anthropometric parameters and metabolic parameters under a high monounsaturated vs. high polyunsaturated fat hypocaloric diets.
}}

{{PMID Auto
|PMID=23407780
|Title=Screening genetic variability at the CNR1 gene in both major depression etiology and clinical response to citalopram treatment.
}}

{{PMID Auto
|PMID=23422373
|Title=CNR1 gene and risk of the metabolic syndrome in patients with schizophrenia.
}}

{{PMID Auto
|PMID=25093427
|Title=Selected CNR1 polymorphisms and hyperandrogenemia as well as fat mass and fat distribution in women with polycystic ovary syndrome
}}

{{PMID Auto
|PMID=25136364
|Title=Cannabinoid receptor 1 gene polymorphisms and nonalcoholic Fatty liver disease in women with polycystic ovary syndrome and in healthy controls
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}