{{Rsnum
|rsid=10498345
|Chromosome=14
|position=38551301
|Orientation=plus
|GMAF=0.112
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;T)
| geno3=(T;T)
| CEU | 0.0 | 0.0 | 100.0
| HCB | 4.4 | 28.9 | 66.7
| JPT | 7.0 | 30.2 | 62.8
| YRI | 0.0 | 29.5 | 70.5
| ASW | 0.0 | 0.0 | 0.0
| CHB | 4.4 | 28.9 | 66.7
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}[[rs10498345]] is a SNP on chromosome 14 that has been associated with coronary spasm (often a precursor to various types of [[heart disease]]) in a study of Japanese women.

For unknown reasons, the prevalence of coronary spasm in higher in Japanese than in Caucasians. In this study of ~800 Japanese individuals, the ~200 women with coronary spasm were found to preferentially harbor the genotype with [[rs10498345]](T), or to put it another way, the [[rs10498345]](A) allele appears to be protective, with an odds ratio of 0.5 (p=3.5x10e-4). No association was seen in males.{{PMID|18075462}}

{{GWAS Summary
|SNP=rs10498345
|PubMedID=18075462
|Condition=Coronary spasm in women
|Gene=Intergenic
|Risk Allele=T
|pValue=9.00E-007
|OR=2.33
|95CI=1.64-3.23
}}

{{PharmGKB
|RSID=rs10498345
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18075462; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: A novel genetic marker for coronary spasm in women from a genome-wide single nucleotide polymorphism analysis (Initial Sample Size: 50 Japanese cases, 50 Japanese controls; Replication Sample Size: 151 Japanese cases, 160 Japanese controls; Risk Allele: rs10498345-T).
|Drugs=
|Drug Classes=
|Diseases=Cardiovascular Diseases; Coronary Disease; Spasm
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356701
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10498345
|overall_frequency_n=13
|overall_frequency_d=128
|overall_frequency=0.101562
|n_genomes=12
|n_genomes_annotated=0
|n_haplomes=14
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}