{{Rsnum
|rsid=10499194
|Chromosome=6
|position=137681500
|Orientation=plus
|GMAF=0.1745
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Summary=(T;T) protective against rheumatoid arthritis
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 66.2 | 32.3 | 1.5
| HCB | 97.8 | 2.2 | 0.0
| JPT | 81.8 | 18.2 | 0.0
| YRI | 81.0 | 19.0 | 0.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 97.8 | 2.2 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{PMID|17982456|OA=1
}} [[rs10499194]] associated with [[rheumatoid arthritis]] 

In a concurrent study, the Wellcome Trust Case Control Consortium (WTCCC) has reported strong association of rheumatoid arthritis susceptibility to a different SNP located 3.8 kb from rs10499194 ([[rs6920220]]; P = 5 x 10(-6) in WTCCC). We show that these two SNP associations are statistically independent, are each reproducible in the comparison of our data and WTCCC data, and define risk and protective haplotypes for rheumatoid arthritis at 6q23.

{{PMID|19417005|OA=1
}} [[rheumatoid arthritis]]
*[[rs6920220]] [P= 2.6 x 10(-6), OR 1.22 (1.13-1.33)]. 
*[[rs5029937]]
*[[rs13207033]] protective [P= 0.0001, OR 0.86 (0.8-0.93)] perfectly correlated with [[rs10499194]]
The combination of the carriage of both risk alleles of rs6920220 and rs5029937 together with the absence of the protective allele of rs13207033 was strongly associated with RA when compared to carriage of none [OR of 1.86 (95% CI) (1.51-2.29)]. This equates to an effect size of 1.50 (95% CI 1.21-1.85)

{{GWAS Summary
|SNP=rs10499194
|PubMedID=17982456
|Condition=Rheumatoid arthritis
|Gene=TNFAIP3, OLIG3
|Risk Allele=C
|pValue=1.00E-009
|OR=1.33
|95CI=1.15-1.52
|OA=1
}}

{{PMID Auto
|PMID=19401279
|Title=Susceptibility variants for rheumatoid arthritis in the TRAF1-C5 and 6q23 loci: a meta-analysis
}}
{{PMID Auto
|PMID=19565500
|Title=Variants in TNFAIP3, STAT4, and C12orf30 loci associated with multiple autoimmune diseases are also associated with juvenile idiopathic arthritis
|OA=1
}}

{{omim
|desc=RHEUMATOID ARTHRITIS; RA
|id=180300
|rsnum=10499194
}}

{{PharmGKB
|RSID=rs10499194
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:17982456; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Two independent alleles at 6q23 associated with risk of rheumatoid arthritis (Initial Sample Size: 397 cases, 1,211 Framingham individuals; Replication Sample Size: 2,283 cases, 3,258 controls; Risk Allele: rs10499194-C).
|Drugs=
|Drug Classes=
|Diseases=Arthritis, Rheumatoid
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356696
}}

{{PMID Auto
|PMID=20112363
|Title=The association of a nonsynonymous single-nucleotide polymorphism in TNFAIP3 with systemic lupus erythematosus and rheumatoid arthritis in the Japanese population
}}

{{PMID Auto
|PMID=19366996
|Title=Association of the 6q23 region with the rate of joint destruction in rheumatoid arthritis
|OA=1
}}

{{PharmGKB
|RSID=rs10499194
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:17982456
|Annotation=This SNP has been associated with risk of rheumatoid arthritis in GWAS and in a case-control study.
|Drugs=
|Drug Classes=
|Diseases=Arthritis, Rheumatoid
|Curation Level=Curated
|PharmGKB Accession ID=PA161613784
}}

{{PMID Auto
|PMID=18794853
|Title=Common variants at CD40 and other loci confer risk of rheumatoid arthritis.
|OA=1
}}

{{PMID Auto
|PMID=18853133
|Title=Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=18987647
|Title=Rheumatoid arthritis: a view of the current genetic landscape.
|OA=1
}}

{{PMID Auto
|PMID=19165918
|Title=Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus.
|OA=1
}}

{{PMID Auto
|PMID=19169254
|Title=Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.
|OA=1
}}

{{PMID Auto
|PMID=19292917
|Title=Analysis of TNFAIP3, a feedback inhibitor of nuclear factor-kappaB and the neighbor intergenic 6q23 region in rheumatoid arthritis susceptibility.
|OA=1
}}

{{PMID Auto
|PMID=19321514
|Title=6q23 polymorphisms in rheumatoid arthritis Spanish patients.
}}

{{PMID Auto
|PMID=19387456
|Title=Meta-analysis and imputation identifies a 109 kb risk haplotype spanning TNFAIP3 associated with lupus nephritis and hematologic manifestations.
|OA=1
}}

{{PMID Auto
|PMID=19439038
|Title=Complex genetic association of 6q23 with autoimmune rheumatic conditions.
|OA=1
}}

{{PMID Auto
|PMID=19445664
|Title=Association of common polymorphisms in known susceptibility genes with rheumatoid arthritis in a Slovak population using osteoarthritis patients as controls.
|OA=1
}}

{{PMID Auto
|PMID=19474294
|Title=Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.
|OA=1
}}

{{PMID Auto
|PMID=19674979
|Title=Overlap of disease susceptibility loci for rheumatoid arthritis and juvenile idiopathic arthritis.
|OA=1
}}

{{PMID Auto
|PMID=19849816
|Title=Genetics of rheumatic disease.
|OA=1
}}

{{PMID Auto
|PMID=20018027
|Title=Conditional analysis of the major histocompatibility complex in rheumatoid arthritis.
|OA=1
}}

{{PMID Auto
|PMID=20439292
|Title=Genetic variants in the prediction of rheumatoid arthritis.
}}

{{PMID Auto
|PMID=20511617
|Title=Association of the TNFAIP3 rs5029939 variant with systemic sclerosis in the European Caucasian population.
}}

{{PMID Auto
|PMID=22402800
|Title=Associations between TNFAIP3 gene polymorphisms and rheumatoid arthritis: a meta-analysis.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10499194
|overall_frequency_n=24
|overall_frequency_d=128
|overall_frequency=0.1875
|n_genomes=22
|n_genomes_annotated=0
|n_haplomes=24
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23161053
|Title=TNFAIP3 gene polymorphisms confer risk for Behcet's disease in a Chinese Han population
}}

{{PMID Auto
|PMID=23450725
|Title=Susceptibility to childhood-onset rheumatoid arthritis: investigation of a weighted genetic risk score that integrates cumulative effects of variants at five genetic loci.
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}