{{Rsnum
|rsid=1050283
|Gene=OLR1
|Chromosome=12
|position=10159690
|Orientation=minus
|GMAF=0.3466
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=OLR1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 23.4 | 51.6 | 25.0
| HCB | 59.9 | 32.8 | 7.3
| JPT | 68.1 | 26.5 | 5.3
| YRI | 76.2 | 21.8 | 2.0
| ASW | 59.6 | 33.3 | 7.0
| CHB | 59.9 | 32.8 | 7.3
| CHD | 54.1 | 34.9 | 11.0
| GIH | 56.6 | 37.4 | 6.1
| LWK | 74.3 | 23.9 | 1.8
| MEX | 0.0 | 0.0 | 0.0
| MKK | 55.8 | 36.5 | 7.7
| TSI | 18.4 | 37.8 | 43.9
| HapMapRevision=28
}}[[rs1050283]], a SNP also known as +1073, is located in the 3' untranslated region of the oxidized low density lipoprotein (lectin-like) receptor 1 [[OLR1]] gene, which is also known as the LOX-1 gene.

The [[rs1050283]](C) allele has been associated with increased risk for [[Alzheimer's disease]] in several studies of ~200 Southern Italian Alzheimer patients. The risk is independent of [[ApoE]] status, and may also be defined by haplotypes including one or both of neighboring SNPs [[rs12316150]] and [[rs669]].[PMID 15860461, PMID 18191876]

{{ neighbor
| rsid = 12316150
| distance = 2
}}

{{PMID Auto
|PMID=21709374
|Title=Role of OLR1 and Its Regulating hsa-miR369-3p in Alzheimer's Disease: Genetics and Expression Analysis
}}

{{PMID Auto
|PMID=18384690
|Title=Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLR1) with CAD.
|OA=1
}}

{{PMID Auto
|PMID=20615707
|Title=Genetic polymorphisms of Chinese patients with ischemic stroke and concurrent stenoses of extracranial and intracranial vessels.
}}

{{PMID Auto
|PMID=20682755
|Title=A pilot study of gene/gene and gene/environment interactions in Alzheimer disease.
|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}