{{Rsnum
|rsid=1050450
|Gene=GPX1
|Chromosome=3
|position=49357401
|Orientation=minus
|GMAF=0.2493
|Gene_s=GPX1,LOC100289130
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{PMID Auto
|PMID=19505917
|Title=Lead exposure, polymorphisms in genes related to oxidative stress, and risk of adult brain tumors
|OA=1
}}

{{PMID Auto
|PMID=20178852
|Title=Association Study between Polymorphisms in Selenoprotein Genes and Susceptibility to Kashin-Beck Disease
}}

{{PMID Auto
|PMID=21062213
|Title=Manganese superoxide dismutase dimorphism relationship with severity and prognosis in cardiogenic shock due to dilated cardiomyopathy
}}
{{PMID Auto
|PMID=21185702
|Title=Association between the rs1050450 glutathione peroxidase-1 (C &gt; T) gene variant and peripheral neuropathy in two independent samples of subjects with diabetes mellitus
}}

{{PMID Auto
|PMID=21795425
|Title=Genetic Variation in Myeloperoxidase Modifies the Association of Serum {alpha}-Tocopherol with Aggressive Prostate Cancer among Current Smokers
|OA=1
}}

{{omim
|id=138320
|rsnum=1050450
|variant=0001
}}

{{ClinVar
|rsid=1050450
|Reversed=1
|FwdREF=C
|FwdALT=T
|REF=G
|ALT=A
|RSPOS=49394834
|CHROM=3
|GMAF=0.25
|dbSNPBuildID=86
|SSR=0
|SAO=1
|VP=0x050168000000170116110100
|GENEINFO=GPX1:2876
|GENE_NAME=GPX1
|GENE_ID=2876
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000003.11:g.49394834G>A
|CLNORIGIN=1
|CLNSIG=2
|Tags=RV;PM;PMC;SLO;VLD;G5A;G5;GNO;KGPhase1;KGPROD;OTHERKG;LSD;OM
|CAF=0.7507; 0.2493
|CLNACC=RCV000017462.1
|CLNDBN=GLUTATHIONE PEROXIDASE POLYMORPHISM
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=138320.0001
|COMMON=1
|Disease=GLUTATHIONE PEROXIDASE POLYMORPHISM
}}

{{PMID|16797832}} GPX1 Pro198Leu polymorphism, interactions with smoking and alcohol consumption, and risk for lung cancer.

{{PMID|16945136|OA=1
}} Gene x Gene interaction between MnSOD and GPX-1 and breast cancer risk: a nested case-control study.

{{PMID|17825092|OA=1
}} Genetic association of glutathione peroxidase-1 with coronary artery calcification in type 2 diabetes: a case control study with multi-slice computed tomography.

{{PMID|18298806|OA=1
}} Do genetic factors protect for early onset lung cancer? A case control study before the age of 50 years.

{{PMID|18340529|OA=1
}} A prospective study of genetic polymorphism in MPO, antioxidant status, and breast cancer risk.

{{PMID|18682580|OA=1
}} Oxidative response gene polymorphisms and risk of adult brain tumors.

{{PMID|19428448|OA=1
}} The Mn-superoxide dismutase single nucleotide polymorphism rs4880 and the glutathione peroxidase 1 single nucleotide polymorphism rs1050450 are associated with aging and longevity in the oldest old.

{{PMID|19946932}} Lack of association of GPX1 and MnSOD genes with symptom severity and response to clozapine treatment in schizophrenia subjects.

{{PMID|20003265|OA=1
}} Extent of differential allelic expression of candidate breast cancer genes is similar in blood and breast.

{{PMID|20444272|OA=1
}} Gene polymorphisms against DNA damage induced by hydrogen peroxide in leukocytes of healthy humans through comet assay: a quasi-experimental study.

{{PMID|20852007}} Effects of selenium status and polymorphisms in selenoprotein genes on prostate cancer risk in a prospective study of European men.

{{PMID|21595856}} Genetic polymorphisms in antioxidative enzymes are associated to forced expiratory volume in 1 s (FEV1) in smokers independently of asthma.

{{PMID|21842217}} GPx-1 polymorphism (rs1050450) contributes to tumor susceptibility: evidence from meta-analysis.

{{PMID|22139612|OA=1
}} Serum selenium and single-nucleotide polymorphisms in genes for selenoproteins: relationship to markers of oxidative stress in men from Auckland, New Zealand.

{{PMID|22661588|OA=1
}} Antioxidant enzyme polymorphisms and neuropsychological outcomes in medulloblastoma survivors: a report from the Childhood Cancer Survivor Study.

{{PMID Auto
|PMID=23073788
|Title=GPX1 gene Pro200Leu polymorphism, erythrocyte GPX activity, and cancer risk
}}

{{GET Evidence
|gene=GPX1
|aa_change=Pro199Leu
|aa_change_short=P199L
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1050450
|overall_frequency_n=2704
|overall_frequency_d=9328
|overall_frequency=0.28988
|n_genomes=3
|n_genomes_annotated=0
|n_haplomes=4
|n_articles=0
|n_articles_annotated=0
|nblosum100=7
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=23906684
|Title=Genetic associations with coronary heart disease: Meta-analyses of 12 candidate genetic variants
}}

{{PMID Auto
|PMID=23363810
|Title=Prostate disease risk factors among a New Zealand cohort
}}

{{PMID Auto
|PMID=24610081
|Title=Associations Between SNPs Within Antioxidant Genes and the Risk of Prostate Cancer in the Siberian Region of Russia
}}

{{PMID Auto
|PMID=22877234
|Title=Polymorphisms in genes involved in oxidative stress response in patients with sudden sensorineural hearing loss and Meniere's disease in a Japanese population.
|OA=1
}}

{{PMID Auto
|PMID=23175176
|Title=Variation in PAH-related DNA adduct levels among non-smokers: the role of multiple genetic polymorphisms and nucleotide excision repair phenotype.
}}

{{PMID Auto
|PMID=24058403
|Title=Association study of polymorphisms in selenoprotein genes and Kashin-Beck disease and serum selenium/iodine concentration in a Tibetan population
}}

{{PMID Auto
|PMID=25009565
|Title=Association of glutathione peroxidase-1 (GPx-1) rs1050450 Pro198Leu and Pro197Leu polymorphisms with cardiovascular risk: a meta-analysis of observational studies
}}

{{PMID Auto
|PMID=25182984
|Title=[Association between GPX-1 single nucleotide polymorphisms and susceptibility to noise-induced hearing loss among Chinese Han population]
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}