{{Rsnum
|rsid=1050501
|Gene=FCGR2B
|Chromosome=1
|position=161674008
|Orientation=plus
|GMAF=0.1869
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=FCGR2B
}}{{PMID Auto
|PMID=19640933
|Title=FCGR2B gene polymorphism rather than FCGR2A, FCGR3A and FCGR3B is associated with anti-GBM disease in Chinese
}}
{{omim
|id=604590
|rsnum=1050501
|variant=0002
}}
{{PMID Auto
|PMID=22416796
|Title=The FCGR2B rs10917661 polymorphism may confer susceptibility to ankylosing spondylitis in Han Chinese: a case-control study
}}{{ClinVar
|rsid=1050501
|Reversed=0
|FwdREF=T
|FwdALT=C
|REF=T
|ALT=C
|RSPOS=161674008
|CHROM=1
|GMAF=0.1877
|dbSNPBuildID=86
|SSR=0
|SAO=1
|VP=0x050168000a05150516110100
|GENEINFO=FCGR2B:2213
|GENE_NAME=FCGR2B
|GENE_ID=2213
|WGT=1
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000001.11:g.161674008T>C
|CLNORIGIN=1
|CLNSIG=255
|Tags=PM;PMC;SLO;NSM;REF;ASP;VLD;G5;HD;GNO;KGPhase1;KGPROD;OTHERKG;LSD;OM
|CAF=0.8131; 0.1869
|CLNACC=RCV000005800.1; RCV000005801.1
|CLNDBN=Systemic lupus erythematosus, susceptibility to; Malaria, resistance to
|CLNDSDB=MedGen
|CLNDSDBID=C2720293
|CLNSRC=ClinVar; OMIM Allelic Variant
|CLNSRCID=NM_004001.4:c.695T>C; 604590.0002
|COMMON=1
|Disease=Systemic lupus erythematosus; Malaria
}}{{PMID|16531013}} Association of Fcgamma receptor IIB gene polymorphism with genetic susceptibility to systemic lupus erythematosus in Chinese populations--a family-based association study.

{{PMID|18625651}} Genetic susceptibility and haplotype analysis between Fcgamma receptor IIB and IIIA gene with systemic lupus erythematosus in Chinese population.

{{PMID|19421223|OA=1
}} Fcgamma receptors: structure, function and role as genetic risk factors in SLE.

{{PMID|20508037|OA=1
}} Copy number, linkage disequilibrium and disease association in the FCGR locus.{{GET Evidence
|gene=FCGR2B
|aa_change=Ile232Thr
|aa_change_short=I232T
|impact=pathogenic
|qualified_impact=Low clinical importance, Likely pathogenic
|inheritance=other
|quality_scores=Array
|dbsnp_id=rs1050501
|overall_frequency_n=1017
|overall_frequency_d=7666
|overall_frequency=0.132664
|n_genomes=3
|n_genomes_annotated=0
|n_haplomes=4
|n_articles=2
|n_articles_annotated=2
|qualityscore_in_silico=1
|qualitycomment_in_silico=Y
|qualityscore_case_control=4
|qualitycomment_case_control=Y
|qualityscore_familial=0
|qualitycomment_familial=Y
|qualityscore_severity=4
|qualitycomment_severity=Y
|qualityscore_treatability=4
|qualitycomment_treatability=Y
|in_omim=Y
|pph2_score=0.003
|nblosum100=3
|autoscore=2
|webscore=N
|variant_evidence=0
|clinical_importance=1
|summary_short=A study in an Asian population associates this variant with increased susceptibility to anti-glomerular basement membrane antibody disease (anti-GBM), an autoimmune disease that causes bleeding, lung, and kidney disease. Even for carriers of this variation, anti-GBM is quite rare -- this variant only increases absolute risk for the disease by 0.1-0.2%. A much weaker finding seems to correlate homozygosity for the variant with increased risk for systemic lupus erythematosus (SLE); if true, the amount of increased risk due to the variant is unclear.
}}
{{PMID Auto
|PMID=24586589
|Title=Functional fcgamma receptor polymorphisms are associated with human allergy
|OA=1
}}{{PMID Auto
|PMID=22922574
|Title=Fcgamma receptor polymorphisms do not predict response to intravenous immunoglobulin in myasthenia gravis.
}}