{{Rsnum
|rsid=10505477
|Chromosome=8
|position=127395198
|Orientation=minus
|GMAF=0.461
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene=LOC101930033
|Gene_s=LOC101930033
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 27.4 | 53.1 | 19.5
| HCB | 36.5 | 48.2 | 15.3
| JPT | 50.4 | 38.9 | 10.6
| YRI | 0.0 | 15.0 | 85.0
| ASW | 12.3 | 29.8 | 57.9
| CHB | 36.5 | 48.2 | 15.3
| CHD | 33.0 | 46.8 | 20.2
| GIH | 26.7 | 44.6 | 28.7
| LWK | 0.0 | 21.8 | 78.2
| MEX | 17.2 | 46.6 | 36.2
| MKK | 1.9 | 35.3 | 62.8
| TSI | 33.3 | 49.0 | 17.6
| HapMapRevision=28
}}{{PMID|18056436}} Associated with risk of [[colorectal cancer]]; (P = 0.005)

{{PMID|18839428}} [[colorectal cancer]] [[rs10505477]] and [[rs6983267]] yielded allelic p-values of 1.42 x 10(-7) and 2.57 x 10(-7), respectively with OR=1.50 (95% CI: 1.29-1.75). Risk region was delineated by SNPs rs10505477 and [[rs7014346]] and comprised 17 kb

{{GWAS Summary
|SNP=rs10505477
|PubMedID=17618283
|Condition=Colorectal cancer
|Gene=ORF DQ515897
|Risk Allele=A
|pValue=3.00E-011
|OR=1.17
|95CI=1.12-1.23
}}

{{omim
|desc=COLORECTAL CANCER, SUSCEPTIBILITY TO, 2; CRCS2
|id=611469
|rsnum=10505477
}}

{{PharmGKB
|RSID=rs10505477
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:17618283; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24 (Initial Sample Size: 1,257 cases, 1,336 controls; Replication Sample Size: 6,223 cases, 6,443 controls; Risk Allele: rs10505477-A).
|Drugs=
|Drug Classes=
|Diseases=Colorectal Neoplasms
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356669
}}

{{PMID Auto
|PMID=21102338
|Title=Possible association between a genetic polymorphism at 8q24 and risk of upper gastrointestinal cancer
|OA=1
}}
{{PMID Auto
|PMID=21129217
|Title=Characterization of the association between 8q24 and colon cancer: gene-environment exploration and meta-analysis
|OA=1
}}

{{PMID Auto
|PMID=21722176
|Title=Association of 8q24.21 locus with the risk of colorectal cancer: A systematic review and meta-analysis
}}

{{PMID Auto
|PMID=22505654
|Title=GWAS-identified colorectal cancer susceptibility loci associated with clinical outcomes
}}

{{PMID Auto
|PMID=17630503
|Title=Genetic variation in 8q24 associated with risk of colorectal cancer.
}}

{{PMID Auto
|PMID=18372901
|Title=Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.
|OA=1
}}

{{PMID Auto
|PMID=18535017
|Title=Pooled analysis of genetic variation at chromosome 8q24 and colorectal neoplasia risk.
|OA=1
}}

{{PMID Auto
|PMID=18577746
|Title=Multiple loci with different cancer specificities within the 8q24 gene desert.
|OA=1
}}

{{PMID Auto
|PMID=18670647
|Title=Homozygous deletions and recurrent amplifications implicate new genes involved in prostate cancer.
|OA=1
}}

{{PMID Auto
|PMID=18973230
|Title=Breast cancer susceptibility alleles and ovarian cancer risk in 2 study populations.
|OA=1
}}

{{PMID Auto
|PMID=19155440
|Title=Meta association of colorectal cancer confirms risk alleles at 8q24 and 18q21.
|OA=1
}}

{{PMID Auto
|PMID=19520795
|Title=Novel single nucleotide polymorphism associations with colorectal cancer on chromosome 8q24 in African and European Americans.
|OA=1
}}

{{PMID Auto
|PMID=20158306
|Title=Variation at 8q24 and 9p24 and risk of epithelial ovarian cancer.
|OA=1
}}

{{PMID Auto
|PMID=20437058
|Title=The utility and predictive value of combinations of low penetrance genes for screening and risk prediction of colorectal cancer.
|OA=1
}}

{{PMID Auto
|PMID=21455501
|Title=Genetic variants on chromosome 8q24 and colorectal neoplasia risk: a case-control study in China and a meta-analysis of the published literature.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10505477
|overall_frequency_n=60
|overall_frequency_d=128
|overall_frequency=0.46875
|n_genomes=35
|n_genomes_annotated=0
|n_haplomes=49
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23677573
|Title=Genome-wide association study identifies possible genetic risk factors for colorectal adenomas
}}

{{PMID Auto
|PMID=22848671
|Title=Association of eleven common, low-penetrance colorectal cancer susceptibility genetic variants at six risk loci with clinical outcome.
|OA=1
}}

{{PMID Auto
|PMID=24854447
|Title=Association analysis of colorectal cancer susceptibility variants with gastric cancer in a Chinese Han population
}}

{{PMID Auto
|PMID=24978480
|Title=A Colorectal Cancer Susceptibility New Variant at 4q26 in the Spanish Population Identified by Genome-Wide Association Analysis
}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}