{{Rsnum
|rsid=1050829
|Gene=G6PD
|Chromosome=X
|position=154535277
|Orientation=plus
|ReferenceAllele=A
|MissenseAllele=G
|GMAF=0.08162
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=G6PD
}}{{omim
|desc=G6PD A+
|id=305900
|rsnum=1050829
|variant=0001
}}

{{ neighbor
| rsid = 1050828
| distance = 725
}}

{{PharmGKB
|RSID=rs1050829
|Name_s=G6PD:A; G6PD:376A>G
|Gene_s=G6PD
|Feature=
|Evidence=PubMed ID:16356170; PubMed ID:16528451; PubMed ID:17223593
|Annotation=Causes a slight decrease in G6PD activity.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA161145074
}}

rs1050829 is a SNP within the [[G6PD]] gene and is located the X chromosome. G6PD codes for the enzyme [[glucose-6-phosphate dehydrogenase]], which helps protect the cell from oxidative damage.  Depending on genotype, an individual may possess one of two primary versions of the G6PD gene; type A and type B. Type A is predominantly found in people who have African ancestry.  Mutations of G6PD can cause varying degrees of [[G6PD deficiency]], which is a disease affecting red blood cells.  For example, an A to G substitution mutation at the rs1050829 locus (also known as A376G) is associated with reduced production of G6PD enzyme. Other mutations causing G6PD deficiency include; [[rs1050828]]. The G6PD deficient genotype A- (~8-20% reduction of G6PD) is typically defined by the possession of both the rs1050829 G allele and the rs1050828 A allele. G6PD deficiency frequency is highest in malarial regions where G6PD deficient individuals are typically less affected by malarial infection ({{PMID|19546473|OA=1
}}).

{{PMID|22438807|OA=1
}} Study of [[malaria]] in Gambian children uses the rs1050829 allele to help detect G6PD deficient individuals.

{{PMID|20459687|OA=1
}}  A total of 72 SNPs were genotyped in two populations in eastern Sudan (Hausa and Massalit), as well as, a cohort of [[malaria]] hospital patients and a control sample set (n=449).  The study found that in comparison to controls (n=69), Massalit individuals (n=60) who possess the rs105829 G allele were less susceptible to malarial infection (p=0.02).

{{PMID|22906837}} In a G6PD deficient Jordanian clinical population, the A376G allele was found to be at a frequency of 21% in males (n=47) and 9% in females (n=16).  Whereas the G6PD deficient G202A/A376G genotype was found to be 19%.

{{PMID|21849081|OA=1
}}  Examines the frequency of G6PD deficiency genotypes in African malarial drug clinical trail patients from five different populations (Burkina Faso, Ghana, Kenya, Nigeria, Tanzania, and Mali). 

{{ClinVar
|rsid=1050829
|Reversed=1
|FwdREF=A
|FwdALT=G
|REF=T
|ALT=C
|RSPOS=153763492
|CHROM=X
|GMAF=0.0813743
|dbSNPBuildID=86
|SSR=0
|SAO=1
|VP=0x05036800000015051e110100
|GENEINFO=G6PD:2539
|GENE_NAME=G6PD
|GENE_ID=2539
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000023.10:g.153763492T>C
|CLNSRC=Emory University; GTR; OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=556; GTR000167633; 305900.0001; 305900.0002; 305900.0023
|CLNSIG=255
|CLNCUI=CN069445
|CLNDBN=G6PD A+; G6pd a-; G6PD MATERA; G6PD BETICA; G6PD CASTILLA; G6PD DISTRITO FEDERAL; G6PD TEPIC; G6PD SANTAMARIA; not provided
|Disease=G6PD A+; G6pd a-; G6PD MATERA; G6PD BETICA; G6PD CASTILLA; G6PD DISTRITO FEDERAL; G6PD TEPIC; G6PD SANTAMARIA; not provided
|CLNACC=RCV000011073.2; RCV000011074.5; RCV000011075.4; RCV000011076.4; RCV000011077.4; RCV000011078.4; RCV000011079.4; RCV000011109.1; RCV000079405.1
|Tags=RV;PM;PMC;S3D;SLO;VLD;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;LSD;OM
|CAF=0.9184; 0.08162
|CLNDSDB=MedGen
|CLNDSDBID=CN069445
|COMMON=1
}}

{{GET Evidence
|gene=G6PD
|aa_change=Asn156Asp
|aa_change_short=N156D
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1050829
|overall_frequency_n=1002
|overall_frequency_d=8761
|overall_frequency=0.114371
|n_genomes=14
|n_genomes_annotated=0
|n_haplomes=20
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|genetests_testable=Y
|nblosum100=-1
|autoscore=2
|n_web_uneval=1
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}