{{Rsnum
|rsid=10508343
|Chromosome=10
|position=8150713
|Orientation=plus
|GMAF=0.0404
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=131
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
}}
{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 0.0 | 0.0 | 100.0
| HCB | 0.0 | 4.7 | 95.3
| JPT | 0.0 | 4.7 | 95.3
| YRI | 0.0 | 0.0 | 100.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 0.0 | 4.7 | 95.3
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=19176441
|Trait=Treatment response for acute lymphoblastic leukemia
|Title=Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia
|RiskAllele=A
|Pval=0.000008
|OR=3.81
|ORtxt=[1.40-10.40]
|OA=1
}}

{{PharmGKB
|RSID=rs10508343
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19176441; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia. (Initial Sample Size: 487 children; Replication Sample Size: NR); (Region: 10p14; Reported Gene(s): Intergenic; Risk Allele: rs10508343-A); (p-value= 0.000008).This variant is associated with Treatment response for acute lymphoblastic leukemia.
|Drugs=
|Drug Classes=
|Diseases=Precursor Cell Lymphoblastic Leukemia-Lymphoma
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740029
}}

{{PharmGKB
|RSID=rs10508343
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19176441
|Annotation=This variant is associated with end-of-induction minimal residual disease (MRD) in childhood acute lymphoblastic leukemia (ALL) from 2 independent cohorts (GWAS result). Risk Allele: A, MAF= 0.04, combined P value= 7.50E-06.
|Drugs=
|Drug Classes=
|Diseases=Neoplasm, Residual; Precursor Cell Lymphoblastic Leukemia-Lymphoma
|Curation Level=Curated
|PharmGKB Accession ID=PA162470160
}}{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10508343
|overall_frequency_n=2
|overall_frequency_d=128
|overall_frequency=0.015625
|n_genomes=1
|n_genomes_annotated=0
|n_haplomes=1
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}