{{Rsnum
|rsid=10509305
|Gene=STOX1
|Chromosome=10
|position=68885620
|Orientation=plus
|ReferenceAllele=A
|MissenseAllele=C
|GMAF=0.1437
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=STOX1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 55.8 | 38.9 | 5.3
| HCB | 88.3 | 10.2 | 1.5
| JPT | 62.8 | 35.4 | 1.8
| YRI | 97.3 | 2.7 | 0.0
| ASW | 91.2 | 7.0 | 1.8
| CHB | 88.3 | 10.2 | 1.5
| CHD | 83.5 | 16.5 | 0.0
| GIH | 61.4 | 34.7 | 4.0
| LWK | 95.5 | 4.5 | 0.0
| MEX | 43.1 | 50.0 | 6.9
| MKK | 82.1 | 17.9 | 0.0
| TSI | 61.8 | 35.3 | 2.9
| HapMapRevision=28
}}

{{Venter SNP
|rsid=10509305
|allele=C
|frequency=0.283
|uid=1103649970872
|type=heterozygous_SNP
|hugo=STOX1
|ensembl gene=ENSG00000165730
|ensembl transcript=ENST00000298596
|sift=
|disease=Defects in STOX1 are the cause of preeclampsia/eclampsia 4 (PEE4) (MIM:609404); also known as gestational proteinuric hypertension. Preeclampsia is a pregnancy-associated disease with maternal symptoms but placental origin. Unlike most other human disorders, it impacts 2 individuals, the mother and her child, both of whom can be severely affected. The pathological mechanism of PEE4 involves the loss of function of STOX1 in the placenta.
}}

{{omim
|id=609397
|rsnum=10509305
|variant=0002
}}

{{ClinVar
|rsid=10509305
|Reversed=0
|FwdREF=A
|FwdALT=C
|REF=A
|ALT=C
|RSPOS=70645376
|CHROM=10
|GMAF=0.1442
|dbSNPBuildID=119
|SSR=0
|SAO=1
|VP=0x05016000000015051f110100
|GENEINFO=STOX1:219736
|GENE_NAME=STOX1
|GENE_ID=219736
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000010.10:g.70645376A>C
|CLNSRC=OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=609397.0002
|CLNSIG=5
|CLNCUI=C1836255
|CLNDBN=Preeclampsia/eclampsia 4
|Disease=Preeclampsia/eclampsia 4
|CLNACC=RCV000001790.1
|Tags=PM;SLO;VLD;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.8563; 0.1437
|CLNDSDB=MedGen:OMIM:Orphanet
|CLNDSDBID=C1836255:609404:275555
|COMMON=1
}}

{{GET Evidence
|gene=STOX1
|aa_change=Glu608Asp
|aa_change_short=E608D
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10509305
|overall_frequency_n=16
|overall_frequency_d=128
|overall_frequency=0.125
|n_genomes=10
|n_genomes_annotated=0
|n_haplomes=12
|n_articles=0
|n_articles_annotated=0
|in_omim=Y
|nblosum100=-2
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}