{{Rsnum
|rsid=1051298
|Gene=SLC19A1
|Chromosome=21
|position=45514912
|Orientation=minus
|GMAF=0.4949
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=SLC19A1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 34.4 | 50.0 | 15.6
| HCB | 22.7 | 47.7 | 29.5
| JPT | 13.6 | 59.1 | 27.3
| YRI | 19.4 | 46.8 | 33.9
| ASW | 0.0 | 0.0 | 0.0
| CHB | 22.7 | 47.7 | 29.5
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs1051298
|Name_s=SLC19A1: exon 6, 3'UTR, 2522C>T, c.*746C>T
|Gene_s=SLC19A1, COL18A1
|Feature=
|Evidence=PubMed ID:19841321
|Annotation=Risk or phenotype-associated allele: heterozygote CT bears the greatest genotypic risk. Phenotype: A significant difference in 3-month progression-free survival was associated with the rs1051298 genotype (CC vs. CT vs. TT: 57%, 29%, 78%) (p = 0.01); and median progression-free survival was associated with the rs1051298 genotype (CC vs. CT vs. TT: 5.7, 2.8, 4.7 months) (p = 0.05). Study size: from a study using 48 patients with metastatic or stage IIIB nonsquamous non-small-cell lung cancer patients given combined pemetrexed/bevacizumab treatment. Significance metric(s): p = 0.01, p = 0.05. Type of association: CO, GN
|Drugs=bevacizumab; pemetrexed
|Drug Classes=
|Diseases=Carcinoma, Non-Small-Cell Lung
|Curation Level=Curated
|PharmGKB Accession ID=PA165109608
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1051298
|overall_frequency_n=54
|overall_frequency_d=110
|overall_frequency=0.490909
|n_genomes=37
|n_genomes_annotated=0
|n_haplomes=51
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}