{{Rsnum
|rsid=10513025
|Chromosome=5
|position=9623510
|Orientation=plus
|GMAF=0.05142
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 0.9 | 7.1 | 92.0
| HCB | 0.0 | 0.7 | 99.3
| JPT | 0.0 | 0.0 | 100.0
| YRI | 1.4 | 21.8 | 76.9
| ASW | 0.0 | 14.0 | 86.0
| CHB | 0.0 | 0.7 | 99.3
| CHD | 0.0 | 0.9 | 99.1
| GIH | 0.0 | 5.0 | 95.0
| LWK | 2.7 | 20.0 | 77.3
| MEX | 0.0 | 10.3 | 89.7
| MKK | 1.9 | 24.4 | 73.7
| TSI | 0.0 | 14.7 | 85.3
| HapMapRevision=28
}}[[rs10513025]] is a SNP located in chromosomal region 5p15, in between the [[SEMA5A]] and [[TAS2R1]] genes.

Based on a linkage and association mapping study of 1,031 multiplex autism families, [[rs10513025]] was found to be associated with [[autism]], and the expression of [[SEMA5A]] was seen to be reduced in brains from autistic patients. Although this finding was replicated, the authors caution that this SNP explains a very small fraction of the heritability of a complex disorder like autism, presumably due to their finding that the most common allele (present at a frequency of ~96%) is the allele associated with higher risk. The much rarer allele, [[rs10513025]](C), is associated with a 0.55x reduced risk for [[autism]] (p=9.6x10e-6).{{doi|10.1038/nature08490}}

{{PMID Auto GWAS
|PMID=19812673
|Trait=Autism
|Title=A genome-wide linkage and association scan reveals novel loci for autism
|RiskAllele=
|Pval=3E-7
|OR=1.81
|ORtxt=[NR]
|OA=1
}}

{{omim
|id=209850
|rsnum=10513025
}}

{{PMID Auto
|PMID=17903299
|Title=A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10513025
|overall_frequency_n=8
|overall_frequency_d=128
|overall_frequency=0.0625
|n_genomes=6
|n_genomes_annotated=0
|n_haplomes=6
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=22739633
|Title=The association of rs4307059 and rs35678 markers with autism spectrum disorders is replicated in Italian families
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}