{{Rsnum
|rsid=1051375
|Gene=CACNA1C
|Chromosome=12
|position=2679713
|Orientation=plus
|GMAF=0.4311
|Gene_s=CACNA1C,SLC26A11
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 100.0 | 0.0 | 0.0
| HCB | 86.7 | 13.3 | 0.0
| JPT | 84.1 | 15.9 | 0.0
| YRI | 0.0 | 0.0 | 0.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 86.7 | 13.3 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs1051375
|Name_s=
|Gene_s=CACNA1C
|Feature=Exon/Syn
|Evidence=PubMed ID:20031608
|Annotation=In a case-control study (258 cases; 774 controls) performed in patients residing in the mainland U.S. or Puerto Rico and who had hypertension and stable coronary artery disease, this SNP was found to be related to primary outcome of atenolol vs. verapamil SR - based treatment. AA genotype was associated with 46% reduction in primary outcome for patients on verapamil SR-based treatment compared to atenolol-based treatment (odds ratio 0.54; 95% CI 0.32 to 0.92), AG genotype showed no difference in primary outcome between the two strategies (odds ratio 1.47; 95% CI 0.86 to 2.53), and GG subjects had more than 4 fold increased risk of primary outcome on verapamil SR-based treatment as opposed to atenolol-based treatment (odds ratio 4.59; 95% CI 1.67 to 12.67). Study size: 258 cases; 774 controls. Study population/ethnicity: subjects residing in the mainland U.S. or Puerto Rico. Type of association: CO; GN; PD. Significance metric(s): P value: P=0.0001.
|Drugs=atenolol; verapamil
|Drug Classes=BETA BLOCKING AGENTS; CALCIUM CHANNEL BLOCKERS
|Diseases=Coronary Artery Disease; Death; Death, Sudden, Cardiac; Hypertension; Myocardial Infarction; Stroke
|Curation Level=Curated
|PharmGKB Accession ID=PA165111676
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1051375
|overall_frequency_n=5889
|overall_frequency_d=10168
|overall_frequency=0.57917
|n_genomes=35
|n_genomes_annotated=0
|n_haplomes=47
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23680436
|Title=Association of genetic variation in CACNA1C with bipolar disorder in Han Chinese
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}