{{Rsnum
|rsid=1051931
|Gene=PLA2G7
|Chromosome=6
|position=46705206
|Orientation=plus
|GMAF=0.2066
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=PLA2G7
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 3.1 | 35.9 | 60.9
| HCB | 2.2 | 28.9 | 68.9
| JPT | 0.0 | 25.0 | 75.0
| YRI | 9.3 | 45.0 | 45.7
| ASW | 0.0 | 0.0 | 0.0
| CHB | 2.2 | 28.9 | 68.9
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 12.8 | 50.6 | 36.5
| TSI | 7.1 | 44.9 | 48.0
| HapMapRevision=28
}}
{{PMID|19135199|OA=1
}} Higher lipoprotein-associated phospholipase predicts cardiovascular disease [[rs2033547]] [[rs1051931]] [[rs10520358]]

{{omim
|desc=ASTHMA AND ATOPY, SUSCEPTIBILITY TO
|id=601690
|rsnum=1051931
|variant=0003
}}

[[asthma]] related

{{ neighbor
| rsid = 16874954
| distance = 4155
}}

{{Venter SNP
|rsid=1051931
|allele=G
|frequency=0.8
|uid=1103652858683
|type=homozygous_SNP
|hugo=PLA2G7
|ensembl gene=ENSG00000146070
|ensembl transcript=ENST00000274793
|sift=TOLERATED
|disease=Defects in PLA2G7 are the cause of platelet-activating factor acetylhydrolase deficiency (PLA2G7 deficiency) (MIM:601690). It is a trait which is present in 27% of Japanese. It could have a significant physiologic effect in the presence of inflammatory bodily responses.
}}

{{ClinVar
|rsid=1051931
|Reversed=0
|FwdREF=A
|FwdALT=G
|REF=A
|ALT=G
|RSPOS=46672943
|CHROM=6
|GMAF=0.2074
|dbSNPBuildID=86
|SSR=0
|SAO=1
|VP=0x05036800000015051f110101
|GENEINFO=PLA2G7:7941
|GENE_NAME=PLA2G7
|GENE_ID=7941
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000006.11:g.46672943A>G
|CLNORIGIN=1
|CLNSIG=255
|Tags=PM;PMC;S3D;SLO;VLD;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.2066; 0.7934
|CLNACC=RCV000008378.1; RCV000049574.1
|CLNDBN=Asthma and atopy, susceptibility to; not provided
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=601690.0003
|COMMON=1
|Disease=Asthma and atopy; not provided
}}

{{PMID Auto
|PMID=18204052
|Title=Comprehensive genetic analysis of the platelet activating factor acetylhydrolase (PLA2G7) gene and cardiovascular disease in case-control and family datasets.
|OA=1
}}

{{PMID Auto
|PMID=18426996
|Title=Relations of inflammatory biomarkers and common genetic variants with arterial stiffness and wave reflection.
|OA=1
}}

{{PMID Auto
|PMID=20442857
|Title=Genome-wide association study of Lp-PLA(2) activity and mass in the Framingham Heart Study.
|OA=1
}}

{{PMID Auto
|PMID=20479152
|Title=PLA2G7 genotype, lipoprotein-associated phospholipase A2 activity, and coronary heart disease risk in 10 494 cases and 15 624 controls of European Ancestry.
|OA=1
}}

{{PMID Auto
|PMID=21834908
|Title=Association between lipoprotein-associated phospholipase A2 gene polymorphism and coronary artery disease in the Chinese Han population.
}}

{{GET Evidence
|gene=PLA2G7
|aa_change=Val379Ala
|aa_change_short=V379A
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1051931
|overall_frequency_n=8426
|overall_frequency_d=10758
|overall_frequency=0.783231
|n_genomes=51
|n_genomes_annotated=0
|n_haplomes=82
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.816
|nblosum100=2
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=23404648
|Title=An association study between genetic polymorphisms related to lipoprotein-associated phospholipase A(2) and coronary heart disease.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}