{{Rsnum
|rsid=1052133
|Gene=OGG1
|Chromosome=3
|position=9757089
|Orientation=plus
|ReferenceAllele=C
|MissenseAllele=G
|GMAF=0.2984
|Gene_s=CAMK1,OGG1
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 65.1 | 28.6 | 6.3
| HCB | 24.4 | 51.1 | 24.4
| JPT | 18.2 | 59.1 | 22.7
| YRI | 74.2 | 22.6 | 3.2
| ASW | 0.0 | 0.0 | 0.0
| CHB | 24.4 | 51.1 | 24.4
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}
[[rs1052133]], also known as Ser326Cys, is a SNP in the oxoguanine glycosylase 1 [[OGG1]] gene, involved in the repair of DNA damage (for example, damage caused by tobacco smoke). The minor (rarer) allele, encoding the cysteine (Cys), is [[rs1052133]](G). Note that associations reported for this SNP are not always replicating in different studies or populations.

A study of 250 Japanese patients with [[bladder cancer]] found an adjusted odds ratio of 2.05 (CI: 1.36-3.08; p = 0.01) for (G;G) homozygotes compared to the other genotypes. In addition, if evaluated only in non-smokers, the adjusted odds ratio increased to 2.78 (CI: 1.39-5.60; p < 0.01).{{PMID|18272472}}

A study of 200 Chinese patients with [[gallbladder cancer]] concluded that increased risk was associated with both the (C;G) genotype (odds ratio 1.9, (CI: = 1.0-3.7) and the (G;G) genotype (odds ratio 4.5, CI: 1.1-22.4).{{PMID|17417784}}

A study of 300 [[lung cancer]] patients of various ethnicities found that the (G;G) genotype was associated with an odds ratio of 2.1 (CI: 1.2-3.7), regardless of sex or ethnicity.{{PMID|11927502}} However, a Danish study of 400 [[lung cancer]] patients found no association.{{PMID|17015267}}

{{PMID Auto
|PMID=19266243
|Title=Single-Nucleotide Polymorphisms of DNA Repair Genes OGG1 and XRCC1: Association with Gallbladder Cancer in North Indian Population
}}

{{PMID Auto
|PMID=19561388
|Title=Common Polymorphisms in the XPD and hOGG1 Genes Are Not Associated with the Risk of Colorectal Cancer in a Polish Population
}}

{{PMID Auto
|PMID=19815090
|Title=The Relation between Endothelial Nitric Oxide Synthase Gene Variants and Primary Open-Angle Glaucoma: Interactions with Gender and Postmenopausal Hormone Use
}}

{{PMID Auto
|PMID=20069464
|Title=OGG1 Ser326Cys Polymorphism and Susceptibility to Esophageal Cancer in Low and High At-Risk Populations of Northern India
}}

{{PMID Auto
|PMID=20571908
|Title=MUTYH Tyr165Cys, OGG1 Ser326Cys and XPD Lys751Gln polymorphisms and head neck cancer susceptibility: a case control study
}}

{{PMID Auto
|PMID=20606456
|Title=The Ser(326)Cys Polymorphism of 8-Oxoguanine Glycosylase 1 (OGG1) Is Associated with Type 2 Diabetes in Mexican Americans
|OA=1
}}

{{PMID Auto
|PMID=21283657
|Title=Gallbladder Cancer Predisposition: A Multigenic Approach to DNA-Repair, Apoptotic and Inflammatory Pathway Genes
|OA=1
}}

{{Venter SNP
|rsid=1052133
|allele=G
|frequency=
|uid=1103656021650
|type=heterozygous_SNP
|hugo=OGG1
|ensembl gene=ENSG00000114026
|ensembl transcript=ENST00000302003
|sift=TOLERATED
|disease=Defects in OGG1 are a cause of renal cell carcinoma (RCC1) (MIM:144700).
}}
{{PMID Auto
|PMID=21622940
|Title=Single Nucleotide Polymorphisms in DNA Repair Genes and Association with Breast Cancer Risk in the WEB Study
|OA=1
}}

{{PMID Auto
|PMID=21727658
|Title=Protective association exhibited by the single nucleotide polymorphism (SNP) rs1052133 in the gene human 8-oxoguanine DNA glycosylase (hOGG1) with the risk of squamous cell carcinomas of the head &amp; neck (SCCHN) among north Indians
|OA=1
}}

{{PMID Auto
|PMID=21915362
|Title=Sequence variants in antioxidant defense and DNA repair genes, dietary antioxidants, and pancreatic cancer risk
|OA=1
}}

{{PMID Auto
|PMID=21914193
|Title=The hOGG1 Ser326Cys Polymorphism and Prostate Cancer Risk: A Meta-Analysis of 2584 cases and 3234 controls
|OA=1
}}

{{PMID Auto
|PMID=21129811
|Title=Associations between polymorphisms in DNA repair genes and TP53 mutations in non-small cell lung cancer
}}

{{PMID Auto
|PMID=21338322
|Title=Parameters of oxidative stress, DNA damage and DNA repair in type 1 and type 2 diabetes mellitus
}}

{{PMID Auto
|PMID=22540013
|Title=The Association between OGG1 Ser326Cys Polymorphism and Lung Cancer Susceptibility: A Meta-Analysis of 27 Studies
|OA=1
}}

{{PMID Auto
|PMID=22659345
|Title=Polymorphisms of DNA repair genes in Korean hepatocellular carcinoma patients with chronic hepatitis B: possible implications on survival
}}

{{PMID Auto
|PMID=16465622
|Title=Bladder cancer predisposition: a multigenic approach to DNA-repair and cell-cycle-control genes.
|OA=1
}}

{{PMID Auto
|PMID=17220334
|Title=High-order interactions among genetic variants in DNA base excision repair pathway genes and smoking in bladder cancer susceptibility.
}}

{{PMID Auto
|PMID=17984110
|Title=Selected base excision repair gene polymorphisms and susceptibility to biliary tract cancer and biliary stones: a population-based case-control study in China.
}}

{{PMID Auto
|PMID=18191955
|Title=Correlating observed odds ratios from lung cancer case-control studies to SNP functional scores predicted by bioinformatic tools.
|OA=1
}}

{{PMID Auto
|PMID=18544627
|Title=Polymorphisms in DNA repair genes, smoking, and pancreatic adenocarcinoma risk.
|OA=1
}}

{{PMID Auto
|PMID=18547414
|Title=Genotyping panel for assessing response to cancer chemotherapy.
|OA=1
}}

{{PMID Auto
|PMID=18569589
|Title=Rapid detection of the hOGG1 Ser326Cys polymorphism using LightCycler technology.
}}

{{PMID Auto
|PMID=18823566
|Title=Association of MUTYH Gln324His and APEX1 Asp148Glu with colorectal cancer and smoking in a Japanese population.
|OA=1
}}

{{PMID Auto
|PMID=18936436
|Title=Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994.
|OA=1
}}

{{PMID Auto
|PMID=18990748
|Title=International Lung Cancer Consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways.
|OA=1
}}

{{PMID Auto
|PMID=18992148
|Title=Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study.
|OA=1
}}

{{PMID Auto
|PMID=19029194
|Title=Base excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African-Americans.
|OA=1
}}

{{PMID Auto
|PMID=19098027
|Title=SNPnexus: a web database for functional annotation of newly discovered and public domain single nucleotide polymorphisms.
|OA=1
}}

{{PMID Auto
|PMID=19124499
|Title=Association and interactions between DNA repair gene polymorphisms and adult glioma.
|OA=1
}}

{{PMID Auto
|PMID=19318434
|Title=Associations between polymorphisms in DNA repair genes and glioblastoma.
|OA=1
}}

{{PMID Auto
|PMID=19443904
|Title=Catalytically impaired hMYH and NEIL1 mutant proteins identified in patients with primary sclerosing cholangitis and cholangiocarcinoma.
|OA=1
}}

{{PMID Auto
|PMID=19536092
|Title=Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array.
|OA=1
}}

{{PMID Auto
|PMID=19674107
|Title=Substrate specificity and excision kinetics of natural polymorphic variants and phosphomimetic mutants of human 8-oxoguanine-DNA glycosylase.
|OA=1
}}

{{PMID Auto
|PMID=19881468
|Title=hOGG1 Ser326Cys polymorphism and risk of lung cancer by histological type.
}}

{{PMID Auto
|PMID=20564624
|Title=Polymorphisms in ERCC2, MSH2, and OGG1 DNA repair genes and gallbladder cancer risk in a population of Northern India.
}}

{{PMID Auto
|PMID=20577654
|Title=XRCC1, but not APE1 and hOGG1 gene polymorphisms is a risk factor for pterygium.
|OA=1
}}

{{PMID Auto
|PMID=21166493
|Title=hOGG1 Ser326Cys polymorphism and renal cell carcinoma risk in a Chinese population.
}}

{{PMID Auto
|PMID=21183201
|Title=DNA repair gene polymorphisms at XRCC1, XRCC3, XPD, and OGG1 loci in Maharashtrian population of central India.
}}

{{PMID Auto
|PMID=21195504
|Title=Association of genetic polymorphisms in DNA repair pathway genes with non-small cell lung cancer risk.
}}

{{PMID Auto
|PMID=21401806
|Title=hOGG1 Ser326Cys polymorphism and risk of childhood acute lymphoblastic leukemia in a Chinese population.
}}

{{PMID Auto
|PMID=21561390
|Title=Association of APE1 and hOGG1 polymorphisms with colorectal cancer risk in a Turkish population.
}}

{{PMID Auto
|PMID=21695387
|Title=Association of OGG1 Ser326Cys polymorphism with colorectal cancer risk: a meta-analysis.
}}

{{PMID Auto
|PMID=21708280
|Title=Candidate gene studies in gallbladder cancer: a systematic review and meta-analysis.
|OA=1
}}

{{PMID Auto
|PMID=21741876
|Title=Polymorphisms in tobacco metabolism and DNA repair genes modulate oral precancer and cancer risk.
}}

{{PMID Auto
|PMID=21974800
|Title=DNA repair gene polymorphisms and risk of early onset colorectal cancer in Lynch syndrome.
}}

{{PMID Auto
|PMID=22469746
|Title=Association between polymorphisms of the DNA base excision repair genes MUTYH and hOGG1 and age-related macular degeneration.
}}

{{PMID Auto
|PMID=22687647
|Title=Polymorphisms in base excision DNA repair genes and association with melanoma risk in a pilot study on Central-South Italian population.
}}

{{PMID Auto
|PMID=22720119
|Title=Association of base excision repair gene polymorphisms with ESRD risk in a Chinese population
|OA=1
}}

{{PMID Auto
|PMID=23079842
|Title=Meta-analysis demonstrates lack of association of the hOGG1 Ser326Cys polymorphism with bladder cancer risk
}}

{{GET Evidence
|gene=OGG1
|aa_change=Ser326Cys
|aa_change_short=S326C
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1052133
|n_genomes=1
|n_genomes_annotated=0
|n_haplomes=2
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.003
|nblosum100=3
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=22850545
|Title=Selected polymorphisms of base excision repair genes and pancreatic cancer risk in Japanese
|OA=1
}}

{{PMID Auto
|PMID=24022861
|Title=An NEIL1 single nucleotide polymorphism (rs4462560) predicts the risk of radiation-induced toxicities in esophageal cancer patients treated with definitive radiotherapy
}}

{{PMID Auto
|PMID=24499375
|Title=Association of Oxidative Stress Related Genes with Idiopathic Recurrent Miscarriage
}}

{{PMID Auto
|PMID=24500421
|Title=Association between DNA repair gene polymorphisms and risk of glioma: A systematic review and meta-analysis
}}

{{PMID Auto
|PMID=22466227
|Title=Genotoxic effects of occupational exposure to lead and influence of polymorphisms in genes involved in lead toxicokinetics and in DNA repair.
}}

{{PMID Auto
|PMID=24036326
|Title=Genotoxic effect of exposure to metal(loid)s. A molecular epidemiology survey of populations living and working in Panasqueira mine area, Portugal
}}

{{PMID Auto
|PMID=23959014
|Title=DNA Repair Genes XRCC1, XRCC3, XPD, and OGG1 Polymorphisms among the Central Region Population of Saudi Arabia
}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}