{{Rsnum
|rsid=1056503
|Gene=XRCC4
|Chromosome=5
|position=83353158
|Orientation=plus
|GMAF=0.3944
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=XRCC4
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 0.0 | 25.7 | 74.3
| HCB | 48.2 | 43.8 | 8.0
| JPT | 38.1 | 51.3 | 10.6
| YRI | 21.8 | 49.0 | 29.3
| ASW | 19.3 | 54.4 | 26.3
| CHB | 48.2 | 43.8 | 8.0
| CHD | 53.2 | 36.7 | 10.1
| GIH | 1.0 | 28.0 | 71.0
| LWK | 27.3 | 50.0 | 22.7
| MEX | 15.5 | 41.4 | 43.1
| MKK | 17.9 | 50.6 | 31.4
| TSI | 1.0 | 20.6 | 78.4
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs1056503
|Name_s=
|Gene_s=XRCC4
|Feature=
|Evidence=PubMed ID:18165945
|Annotation=This variant may be associated with risk of developing glioma.
|Drugs=
|Drug Classes=
|Diseases=Glioma
|Curation Level=Curated
|PharmGKB Accession ID=PA161615704
}}

{{PMID|16091150|OA=1
}} Characterization of the linkage disequilibrium structure and identification of tagging-SNPs in five DNA repair genes.

{{PMID|16857995|OA=1
}} Risk of non-Hodgkin lymphoma (NHL) in relation to germline variation in DNA repair and related genes.

{{PMID|19276285|OA=1
}} Associations between single nucleotide polymorphisms in double-stranded DNA repair pathway genes and familial breast cancer.

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1056503
|overall_frequency_n=2508
|overall_frequency_d=10756
|overall_frequency=0.233172
|n_genomes=25
|n_genomes_annotated=0
|n_haplomes=36
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23924833
|Title=Association of XRCC3 and XRCC4 gene polymorphisms, family history of cancer and tobacco smoking with non-small-cell lung cancer in a Chinese population: a case-control study
}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}