{{Rsnum
|rsid=1059702
|Gene=IRAK1
|Chromosome=X
|position=154018741
|Orientation=minus
|GMAF=0.3222
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=IRAK1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 100.0 | 0.0 | 0.0
| HCB | 6.7 | 20.0 | 73.3
| JPT | 11.4 | 13.6 | 75.0
| YRI | 98.6 | 0.7 | 0.7
| ASW | 96.4 | 3.6 | 0.0
| CHB | 6.7 | 20.0 | 73.3
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 97.3 | 1.8 | 0.9
| MEX | 0.0 | 0.0 | 0.0
| MKK | 94.9 | 0.6 | 4.5
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{PMID Auto
|PMID=21933552
|Title=Functional polymorphism in exon 5 and variant haplotype of the interleukin-1 receptor-associated kinase 1 gene are associated with susceptibility to and severity of sepsis in the Chinese population
}}

{{PMID Auto
|PMID=17382928
|Title=The association between innate immunity gene (IRAK1) and C-reactive protein in the Diabetes Heart Study.
|OA=1
}}

{{PMID Auto
|PMID=19505919
|Title=Toll-like receptor signaling pathway variants and prostate cancer mortality.
|OA=1
}}

{{PMID Auto
|PMID=21898345
|Title=Evidence of the contribution of the X chromosome to systemic sclerosis susceptibility: association with the functional IRAK1 196Phe/532Ser haplotype.
}}

{{GET Evidence
|gene=IRAK1
|aa_change=Phe196Ser
|aa_change_short=F196S
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1059702
|overall_frequency_n=7853
|overall_frequency_d=8761
|overall_frequency=0.896359
|n_genomes=44
|n_genomes_annotated=0
|n_haplomes=85
|n_articles=0
|n_articles_annotated=0
|nblosum100=5
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=23233309
|Title=An activity-enhancing variant of IRAK1 and an MECP2-IRAK1 haplotype associating with increased susceptibility to rheumatoid arthritis
}}

{{PMID Auto
|PMID=23444193
|Title=New insight on the Xq28 association with systemic sclerosis
}}

{{PMID Auto
|PMID=22904263
|Title=Fine mapping of Xq28: both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups.
|OA=1
}}

{{PMID Auto
|PMID=23435933
|Title=Association of interleukin-1 receptor-associated kinase (IRAK1) gene polymorphisms (rs3027898, rs1059702) with systemic lupus erythematosus in a Chinese Han population.
}}

{{PMID Auto
|PMID=24709033
|Title=Analysis of two autoimmunity genes, IRAK1 and MECP2, in giant cell arteritis
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}