{{Rsnum
|rsid=1059703
|Gene=IRAK1
|Chromosome=X
|position=154013378
|Orientation=minus
|ReferenceAllele=C
|MissenseAllele=T
|GMAF=0.4305
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|effect1=
|effect2=
|effect3=
|Gene_s=IRAK1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 18.5 | 9.2 | 72.3
| HCB | 73.3 | 20.0 | 6.7
| JPT | 72.7 | 13.6 | 13.6
| YRI | 24.6 | 23.0 | 52.5
| ASW | 0.0 | 0.0 | 0.0
| CHB | 73.3 | 20.0 | 6.7
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}The C->T (Ser532Leu, [[rs1059703]]) polymorphism of the [[IRAK1]] gene was significantly associated with atherothrombotic cerebral infarction in a study of 3,400+ Japanese adults.{{PMID|18566305}}
{{PMID Auto
|PMID=20500689
|Title=The Role of microRNA-146a (miR-146a) and its Target IL-1R-Associated Kinase (IRAK1) in Psoriatic Arthritis Susceptibility
}}
{{PMID Auto
|PMID=20870441
|Title=A polymorphism in the 3'-UTR of interleukin-1 receptor-associated kinase (IRAK1), a target gene of miR-146a, is associated with rheumatoid arthritis susceptibility
}}{{PMID Auto
|PMID=17382928
|Title=The association between innate immunity gene (IRAK1) and C-reactive protein in the Diabetes Heart Study.
|OA=1
}}

{{PMID Auto
|PMID=18987746
|Title=Association of interacting genes in the toll-like receptor signaling pathway and the antibody response to pertussis vaccination.
|OA=1
}}

{{PMID Auto
|PMID=19288030
|Title=Association of genetic variants with chronic kidney disease in Japanese individuals with type 2 diabetes mellitus.
}}

{{PMID Auto
|PMID=19505919
|Title=Toll-like receptor signaling pathway variants and prostate cancer mortality.
|OA=1
}}

{{PMID Auto
|PMID=20463618
|Title=Role of polymorphic variants as genetic modulators of infection in neonatal sepsis.
|OA=1
}}{{GET Evidence
|gene=IRAK1
|aa_change=Ser532Leu
|aa_change_short=S532L
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1059703
|overall_frequency_n=6733
|overall_frequency_d=8644
|overall_frequency=0.778922
|n_genomes=40
|n_genomes_annotated=0
|n_haplomes=71
|n_articles=0
|n_articles_annotated=0
|nblosum100=6
|autoscore=0
|webscore=N
}}
{{PMID Auto
|PMID=23233309
|Title=An activity-enhancing variant of IRAK1 and an MECP2-IRAK1 haplotype associating with increased susceptibility to rheumatoid arthritis
}}
{{PMID Auto
|PMID=23867959
|Title=Toll-like receptor genetic variants are associated with Gram-negative infections in VLBW infants
}}