{{Rsnum
|rsid=1060896
|Gene=SLC28A2
|Chromosome=15
|position=45262069
|Orientation=plus
|GMAF=0.3421
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=LOC101928414,SLC28A2
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 43.8 | 45.5 | 10.7
| HCB | 1.5 | 13.2 | 85.3
| JPT | 0.0 | 7.1 | 92.9
| YRI | 0.0 | 17.0 | 83.0
| ASW | 3.5 | 24.6 | 71.9
| CHB | 1.5 | 13.2 | 85.3
| CHD | 0.9 | 12.0 | 87.0
| GIH | 29.7 | 41.6 | 28.7
| LWK | 3.6 | 20.9 | 75.5
| MEX | 17.2 | 41.4 | 41.4
| MKK | 0.0 | 17.9 | 82.1
| TSI | 42.2 | 41.2 | 16.7
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs1060896
|Name_s=SLC28A2:283A>C, 225A>C, mRNA 284A>C, R75S
|Gene_s=SLC28A2
|Feature=Exon/NonSyn
|Evidence=PubMed ID:15224082
|Annotation=Risk or phenotype-associated allele: None. Phenotype: Variants identified in a screen of 13 genes involved in the gemcitabine drug metabolic pathway. For the non-synonymous SLC28A2:283A>C (R75S) SNP, the C (75Ser) allele was at frequency was 0.34 and 0.08 in Europeans and Africans, respectively. There was a significant difference between ethnic groups in genotype frequency distribution (p < 0.001). Study size: 187. Study population/ethnicity: Healthy, unrelated blood donors of European (n = 95) and African (n = 92) descent. Significance metric(s): p < 0.001. Type of association: GN.
|Drugs=gemcitabine
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA165110723
}}

{{GET Evidence
|gene=SLC28A2
|aa_change=Ser75Arg
|aa_change_short=S75R
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1060896
|overall_frequency_n=5351
|overall_frequency_d=10758
|overall_frequency=0.497397
|n_genomes=23
|n_genomes_annotated=0
|n_haplomes=32
|n_articles=1
|n_articles_annotated=1
|in_pharmgkb=Y
|nblosum100=3
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}