{{Rsnum
|rsid=1061170
|Gene=CFH
|Chromosome=1
|position=196690107
|Orientation=plus
|ReferenceAllele=C
|MissenseAllele=T
|GMAF=0.2778
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=CFH
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 0.0 | 58.3 | 41.7
| HCB | 0.0 | 13.3 | 86.7
| JPT | 0.0 | 11.4 | 88.6
| YRI | 1.7 | 50.0 | 48.3
| ASW | 0.0 | 0.0 | 0.0
| CHB | 0.0 | 13.3 | 86.7
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{ neighbor
| rsid = 1061147
| distance = 4913
}}

[[rs1061170]] is a SNP in the complement factor H [[CFH]] gene; it is also known as Tyr402His. The [[rs1061170]](T) allele encodes the more common Tyr (Y), while the generally rarer [[rs1061170]](C) encodes the His (H).

This SNP has been associated primarily with [[age related macular degeneration]], and to a lesser extent, with [[longevity]].

This [http://jama.ama-assn.org/cgi/content/short/296/3/301 research paper] shows that [[CFH]] Y402H is the relevant mutation. {{PMID|16849663}}

A haplotype of [[rs1061170]] [[rs3753394]] [[rs800292]] [[rs1329428]] (TGTC) was found to confer a significantly increased likelihood of exudative AMD. {{PMID|17167412}}

[[rs1061170]] (aka Y402H 1277 T>C) was not associated with exudative [[AMD]].

[[CFH]] variations appear to contribute to [[ARMD]] in Caucasians, but not in Japanese {{PMID|16710702}}

[[CFH]] variant [[rs1061170]] Y402H is strongly associated with both dry and wet [[AMD]] {{PMID|17306880}}

[[rs1061170]](C) alleles are significantly associated with increased susceptibility to early [[AMD]] in Taiwan Chinese populations.{{PMID|18784628}}

Some SNPs in other genes (like [[C7]] and [[MBL2]]) may protect individuals with one or two of the [[rs1061170]](C) risk alleles. {{PMID|17266113}}

{{PMID|18682806|OA=1
}} An analysis of the joint effects of [[rs1061170]], [[rs11200638]] and [[rs10490924]] on [[AMD]]

In a 4 year study of [[longevity]] of 491 nonagenarians in the Finnish Vitality 90+ study, risk factor-adjusted mortality was significantly higher among the [[rs1061170]](C) carriers compared to non-carriers (odds ratio 1.78, CI 1.19-2.67, p = 0.005), and the survival curves of these carriers and non-carriers deviated significantly (p = 0.016). In other words, in this study, [[rs1061170]](T;T) individuals generally lived longer than (C) allele carriers. {{PMID|19000922}}

[[age related macular degeneration]] {{PMID|15870199|OA=1
}}

{{omim
|desc=MACULAR DEGENERATION, AGE-RELATED, 4
|id=134370
|quiet=1
|rsnum=1061170
|variant=0008
}}

{{Venter SNP
|rsid=1061170
|allele=T
|frequency=
|uid=1103675303121
|type=heterozygous_SNP
|hugo=CFH
|ensembl gene=ENSG00000000971
|ensembl transcript=ENST00000367429
|sift=TOLERATED
|disease=Defects in CFH are a cause of suscpetibility to age- related macular degeneration 1 (ARMD1) (MIM:603075). ARMD is the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid (known as drusen) that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. ARMD is likely to be a mechanistically heterogeneous group of disorders, and the specific disease mechanisms that underlie the vast majority of cases are currently unknown. However, a number of studies have suggested that both genetic and environmental factors are likely to play a role.
}}

{{PMID Auto
|PMID=19399715
|Title=Impact of interacting functional variants in COMT on regional gray matter volume in human brain
}}

{{PMID Auto
|PMID=19680273
|Title=ARMS2/HTRA1 and CFH polymorphisms are not associated with choroidal neovascularization in highly myopic eyes of the elderly Japanese population
}}
{{PMID Auto
|PMID=19692124
|Title=Complement Factor H Y402H and C-Reactive Protein Polymorphism and Photodynamic Therapy Response in Age-Related Macular Degeneration
}}
{{PMID Auto
|PMID=19797206
|Title=Susceptibility genes and progression in age-related maculopathy - a study of single eyes. The prospective Muenster Ageing and Retina Study (MARS)
}}

{{PharmGKB
|RSID=rs1061170
|Name_s=CFH:Y402H
|Gene_s=CFH
|Feature=
|Evidence=PubMed ID:17053109
|Annotation=In confirmation of other studies, the C allele of rs1061170 was found to be significantly associated with risk of Age-related Macular degeneration in a Caucasion (White) case-control study.
|Drugs=
|Drug Classes=
|Diseases=Macular Degeneration
|Curation Level=Curated
|PharmGKB Accession ID=PA161889381
}}
{{PMID Auto
|PMID=19899988
|Title=Association of c3 gene polymorphisms with neovascular age-related macular degeneration in a chinese population
}}

{{PMID Auto
|PMID=20132989
|Title=Phenotype and Genotype Characteristics of Age-related Macular Degeneration in a Japanese Population
}}

{{PMID Auto GWAS
|PMID=20385826
|Trait=Age-related macular degeneration
|Title=Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC)
|RiskAllele=
|Pval=4E-117
|OR=None
|ORtxt=None
|OA=1
}}
{{PMID Auto
|PMID=20678803
|Title=Complement Factor H and High-Temperature Requirement A-1 Genotypes and Treatment Response of Age-related Macular Degeneration
}}
{{PMID Auto
|PMID=20688737
|Title=Joint Effect of Cigarette Smoking, CFH and LOC387715/HTRA1 Polymorphisms on Polypoidal Choroidal Vasculopathy
}}
{{PMID Auto
|PMID=20708732
|Title=Genetic variation in complement factor H and risk of coronary heart disease: Eight new studies and a meta-analysis of around 48,000 individuals
}}
{{PMID Auto
|PMID=20843825
|Title=An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related macular degeneration (AMD)
}}

{{PMID Auto GWAS
|PMID=21665990
|Trait=None
|Title=Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration.
|RiskAllele=C
|Pval=0
|OR=2.4100
|ORtxt=[NR]
|OA=1
}}

{{PMID Auto
|PMID=21825189
|Title=Complement Factor H 402H Variant and Reticular Macular Disease
|OA=1
}}

{{PMID Auto
|PMID=21882633
|Title=[Influence of genetic mutations on clinical presentation of subretinal neovascularization. Report 1: The impact of CFH and IL-8 genes polymorphism]
}}

{{PMID Auto
|PMID=21871809
|Title=Complement Factor H Y402H polymorphism is associated with an increased risk of mortality after intracerebral hemorrhage
}}

{{PMID Auto
|PMID=22019782
|Title=A rare penetrant mutation in CFH confers high risk of age-related macular degeneration
|OA=1
}}

{{PMID Auto
|PMID=22197220
|Title=Cigarette smoking strongly modifies the association of complement factor H variant and the risk of lung cancer
}}

{{PMID Auto
|PMID=22253316
|Title=Complement factor H genetic variant and age-related macular degeneration: effect size, modifiers and relationship to disease subtype
|OA=1
}}

{{PMID Auto
|PMID=21913742
|Title=Genetic predictors of response to photodynamictherapy
}}

{{PMID Auto
|PMID=22509112
|Title=Genetic associations in polypoidal choroidal vasculopathy: A systematic review and meta-analysis
|OA=1
}}

{{PMID Auto
|PMID=22552255
|Title=Retinal function and CFH-ARMS2 polymorphisms analysis: a pilot study in Italian AMD patients
}}

{{PMID Auto
|PMID=22558131
|Title=Comprehensive Analysis of Copy Number Variation of Genes at Chromosome 1 and 10 Loci Associated with Late Age Related Macular Degeneration
|OA=1
}}

{{PMID Auto
|PMID=22666427
|Title=Modelling the Genetic Risk in Age-Related Macular Degeneration
|OA=1
}}

{{PMID Auto
|PMID=22699975
|Title=Genetic analysis of simultaneous geographic atrophy and choroidal neovascularization
|OA=1
}}

{{ClinVar
|rsid=1061170
|Reversed=0
|FwdREF=C
|FwdALT=T
|REF=C
|ALT=T
|RSPOS=196690107
|CHROM=1
|GMAF=0.2784
|dbSNPBuildID=86
|SSR=0
|SAO=1
|VP=0x050368000a05170517130101
|GENEINFO=CFH:3075
|GENE_NAME=CFH
|GENE_ID=3075
|WGT=1
|VC=SNV
|CLNALLE=0
|CLNHGVS=NC_000001.11:g.196690107C\x3d
|CLNSRC=ClinVar; GTR; OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=NM_000186.3:c.1204C\x3d; GTR000325422; 134370.0008
|CLNSIG=255
|CLNCUI=C1853147; C0730295
|CLNDBN=Age-related macular degeneration 4; Basal laminar drusen
|Disease=Age-related macular degeneration 4; Basal laminar drusen
|CLNACC=RCV000018015.1; RCV000018016.26
|Tags=PM;PMC;S3D;SLO;NSM;REF;ASP;VLD;G5A;G5;HD;GNO;KGPhase1;KGPROD;OTHERKG;PH3;LSD;MTP;OM
|CAF=0.2778; 0.7222
|CLNDSDB=MedGen:OMIM; MedGen:OMIM:Orphanet:SNOMED_CT
|CLNDSDBID=C1853147:610698; C0730295:126700:ORPHA75376:312926005
|COMMON=1
}}

{{PMID Auto
|PMID=15761122
|Title=Complement factor H polymorphism in age-related macular degeneration.
|OA=1
}}

{{PMID Auto
|PMID=16080115
|Title=Susceptibility genes for age-related maculopathy on chromosome 10q26.
|OA=1
}}

{{PMID Auto
|PMID=16519819
|Title=Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases.
|OA=1
}}

{{PMID Auto
|PMID=16630992
|Title=A common polymorphism in the complement factor H gene is associated with increased risk of myocardial infarction: the Rotterdam Study.
}}

{{PMID Auto
|PMID=16642439
|Title=Cigarette smoking strongly modifies the association of LOC387715 and age-related macular degeneration.
|OA=1
}}

{{PMID Auto
|PMID=16723442
|Title=A prospective assessment of the Y402H variant in complement factor H, genetic variants in C-reactive protein, and risk of age-related macular degeneration.
|OA=1
}}

{{PMID Auto
|PMID=16828512
|Title=Complement factor H increases risk for atrophic age-related macular degeneration.
}}

{{PMID Auto
|PMID=16865697
|Title=Ethnic variation in AMD-associated complement factor H polymorphism p.Tyr402His.
}}

{{PMID Auto
|PMID=16936733
|Title=CFH haplotypes without the Y402H coding variant show strong association with susceptibility to age-related macular degeneration.
|OA=1
}}

{{PMID Auto
|PMID=17022693
|Title=Determination of complement factor H functional polymorphisms (V62I, Y402H, and E936D) using sequence-specific primer PCR and restriction fragment length polymorphisms.
}}

{{PMID Auto
|PMID=17210853
|Title=Neovascular age-related macular degeneration and its association with LOC387715 and complement factor H polymorphism.
}}

{{PMID Auto
|PMID=17327825
|Title=An update on the genetics of age-related macular degeneration.
|OA=1
}}

{{PMID Auto
|PMID=17591627
|Title=Complement factor H and hemicentin-1 in age-related macular degeneration and renal phenotypes.
}}

{{PMID Auto
|PMID=17697822
|Title=Usefulness of combining complement factor H and C-reactive protein genetic profiles for predicting myocardial infarction (from the Rotterdam Study).
}}

{{PMID Auto
|PMID=17877809
|Title=Genetic variants of complement factor H gene are not associated with premature coronary heart disease: a family-based study in the Irish population.
|OA=1
}}

{{PMID Auto
|PMID=17917691
|Title=Genetic markers and biomarkers for age-related macular degeneration.
|OA=1
}}

{{PMID Auto
|PMID=17940599
|Title=Assembly of inflammation-related genes for pathway-focused genetic analysis.
|OA=1
}}

{{PMID Auto
|PMID=17962488
|Title=Coding and noncoding variants in the CFH gene and cigarette smoking influence the risk of age-related macular degeneration in a Japanese population.
}}

{{PMID Auto
|PMID=18043728
|Title=Haplotypes in the complement factor H (CFH) gene: associations with drusen and advanced age-related macular degeneration.
|OA=1
}}

{{PMID Auto
|PMID=18067970
|Title=Peripheral reticular pigmentary change is associated with complement factor H polymorphism (Y402H) in age-related macular degeneration.
}}

{{PMID Auto
|PMID=18081690
|Title=Translational mini-review series on complement factor H: genetics and disease associations of human complement factor H.
|OA=1
}}

{{PMID Auto
|PMID=18162041
|Title=Neovascular age-related macular degeneration risk based on CFH, LOC387715/HTRA1, and smoking.
|OA=1
}}

{{PMID Auto
|PMID=18248681
|Title=Prevalence of common disease-associated variants in Asian Indians.
|OA=1
}}

{{PMID Auto
|PMID=18378209
|Title=Vascular endothelial growth factor gene polymorphisms in age-related macular degeneration.
}}

{{PMID Auto
|PMID=18423869
|Title=CFH and LOC387715/ARMS2 genotypes and treatment with antioxidants and zinc for age-related macular degeneration.
}}

{{PMID Auto
|PMID=18436811
|Title=Variants in the 10q26 gene cluster (LOC387715 and HTRA1) exhibit enhanced risk of age-related macular degeneration along with CFH in Indian patients.
}}

{{PMID Auto
|PMID=18493315
|Title=C2 and CFB genes in age-related maculopathy and joint action with CFH and LOC387715 genes.
|OA=1
}}

{{PMID Auto
|PMID=18515590
|Title=Association analysis of CFH, C2, BF, and HTRA1 gene polymorphisms in Chinese patients with polypoidal choroidal vasculopathy.
}}

{{PMID Auto
|PMID=18541031
|Title=The NEI/NCBI dbGAP database: genotypes and haplotypes that may specifically predispose to risk of neovascular age-related macular degeneration.
|OA=1
}}

{{PMID Auto
|PMID=18682812
|Title=Association of CFH, LOC387715, and HTRA1 polymorphisms with exudative age-related macular degeneration in a northern Chinese population.
|OA=1
}}

{{PMID Auto
|PMID=19026761
|Title=Molecular pathology of age-related macular degeneration.
|OA=1
}}

{{PMID Auto
|PMID=19074778
|Title=Combined effects of complement factor H genotypes, fish consumption, and inflammatory markers on long-term risk for age-related macular degeneration in a cohort.
|OA=1
}}

{{PMID Auto
|PMID=19076828
|Title=Genetics of C-reactive protein and complement factor H have an epistatic effect on carotid artery compliance: the Cardiovascular Risk in Young Finns Study.
|OA=1
}}

{{PMID Auto
|PMID=19077177
|Title=Genetic variability within the innate immune system influences personality traits in women.
}}

{{PMID Auto
|PMID=19091853
|Title=Pharmacogenetics of complement factor H (Y402H) and treatment of exudative age-related macular degeneration with ranibizumab.
|OA=1
}}

{{PMID Auto
|PMID=19169232
|Title=Variations in five genes and the severity of age-related macular degeneration: results from the Muenster aging and retina study.
}}

{{PMID Auto
|PMID=19187590
|Title=Genetic variants in three genes and smoking show strong associations with susceptibility to exudative age-related macular degeneration in a Chinese population.
}}

{{PMID Auto
|PMID=19187823
|Title=Coding variant I62V in the complement factor H gene is strongly associated with polypoidal choroidal vasculopathy.
}}

{{PMID Auto
|PMID=19202148
|Title=Assessing susceptibility to age-related macular degeneration with proteomic and genomic biomarkers.
|OA=1
}}

{{PMID Auto
|PMID=19226183
|Title=Donor-derived brain tumor following neural stem cell transplantation in an ataxia telangiectasia patient.
|OA=1
}}

{{PMID Auto
|PMID=19259132
|Title=Multilocus analysis of age-related macular degeneration.
|OA=1
}}

{{PMID Auto
|PMID=19381347
|Title=Single nucleotide polymorphisms of the tenomodulin gene (TNMD) in age-related macular degeneration.
|OA=1
}}

{{PMID Auto
|PMID=19661236
|Title=Plasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes.
|OA=1
}}

{{PMID Auto
|PMID=19779542
|Title=A genome-wide association analysis identified a novel susceptible locus for pathological myopia at 11q24.1.
|OA=1
}}

{{PMID Auto
|PMID=19806217
|Title=rs5888 variant of SCARB1 gene is a possible susceptibility factor for age-related macular degeneration.
|OA=1
}}

{{PMID Auto
|PMID=19823576
|Title=CFH, C3 and ARMS2 are significant risk loci for susceptibility but not for disease progression of geographic atrophy due to AMD.
|OA=1
}}

{{PMID Auto
|PMID=19861685
|Title=Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome.
|OA=1
}}

{{PMID Auto
|PMID=19958499
|Title=A particle swarm based hybrid system for imbalanced medical data sampling.
|OA=1
}}

{{PMID Auto
|PMID=20157352
|Title=Genetic analysis of typical wet-type age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese population.
|OA=1
}}

{{PMID Auto
|PMID=20157618
|Title=Complement component 3: an assessment of association with AMD and analysis of gene-gene and gene-environment interactions in a Northern Irish cohort.
|OA=1
}}

{{PMID Auto
|PMID=20339564
|Title=Risk factors for age-related maculopathy.
|OA=1
}}

{{PMID Auto
|PMID=20346514
|Title=C-reactive protein and CFH, ARMS2/HTRA1 gene variants are independently associated with risk of macular degeneration.
|OA=1
}}

{{PMID Auto
|PMID=20378180
|Title=Three major loci involved in age-related macular degeneration are also associated with polypoidal choroidal vasculopathy.
|OA=1
}}

{{PMID Auto
|PMID=20664795
|Title=R102G polymorphism of the C3 gene associated with exudative age-related macular degeneration in a French population.
|OA=1
}}

{{PMID Auto
|PMID=20689796
|Title=Monozygotic twins with polypoidal choroidal vasuculopathy.
|OA=1
}}

{{PMID Auto
|PMID=21111031
|Title=Correlation of complement factor H gene polymorphisms with exudative age-related macular degeneration in a Chinese cohort.
}}

{{PMID Auto
|PMID=21402993
|Title=Assessing susceptibility to age-related macular degeneration with genetic markers and environmental factors.
}}

{{PMID Auto
|PMID=21455292
|Title=Using genetic variation and environmental risk factor data to identify individuals at high risk for age-related macular degeneration.
|OA=1
}}

{{PMID Auto
|PMID=21498607
|Title=Identification of urinary biomarkers for age-related macular degeneration.
}}

{{PMID Auto
|PMID=21558292
|Title=CFH, VEGF and HTRA1 promoter genotype may influence the response to intravitreal ranibizumab therapy for neovascular age-related macular degeneration.
}}

{{PMID Auto
|PMID=21609242
|Title=Age-related macular degeneration-susceptibility single nucleotide polymorphisms in a han chinese control population.
}}

{{PMID Auto
|PMID=21878851
|Title=Association between high-risk disease loci and response to anti-vascular endothelial growth factor treatment for wet age-related macular degeneration.
}}

{{PMID Auto
|PMID=22293892
|Title=A69S and R38X ARMS2 and Y402H CFH gene polymorphisms as risk factors for neovascular age-related macular degeneration in Poland - a brief report.
|OA=1
}}

{{PMID Auto
|PMID=22618592
|Title=Association of genetic polymorphisms and age-related macular degeneration in chinese population.
}}

{{PMID Auto GWAS
|PMID=22705344
|Trait=None
|Title=Heritability and Genome-Wide Association Study to Assess Genetic Differences between Advanced Age-Related Macular Degeneration Subtypes.
|RiskAllele=
|Pval=5E-67
|OR=2.7800
|ORtxt=None
|OA=1
}}

{{PMID Auto
|PMID=22977134
|Title=Single nucleotide polymorphism in the cholesterol-24S-hydroxylase (CYP46A1) gene and its association with CFH and LOC387715 gene polymorphisms in AMD
}}

{{GET Evidence
|gene=CFH
|aa_change=His402Tyr
|aa_change_short=H402Y
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1061170
|overall_frequency_n=6732
|overall_frequency_d=10758
|overall_frequency=0.625767
|n_genomes=44
|n_genomes_annotated=0
|n_haplomes=72
|n_articles=0
|n_articles_annotated=0
|qualityscore_in_silico=2
|qualitycomment_in_silico=Y
|gene_in_genetests=Y
|genetests_testable=Y
|genetests_reviewed=Y
|nblosum100=-1
|autoscore=3
|n_web_uneval=8
}}

{{PMID Auto
|PMID=23337555
|Title=Pharmacogenetics for Genes Associated with Age-Related Macular Degeneration in the Comparison of AMD Treatments Trials (CATT)
|OA=1
}}

{{PMID Auto
|PMID=23111182
|Title=Prevalence and genomic association of reticular pseudodrusen in age-related macular degeneration
}}

{{PMID Auto
|PMID=23302509
|Title=Mitochondrial DNA haplogroups confer differences in risk for age-related macular degeneration: a case control study
|OA=1
}}

{{PMID Auto
|PMID=23098369
|Title=ARMS2 increases the risk of early and late age-related macular degeneration in the European Eye Study
}}

{{PMID Auto
|PMID=23582991
|Title=Genetic Influences on the Outcome of Anti-Vascular Endothelial Growth Factor Treatment in Neovascular Age-related Macular Degeneration
}}

{{PMID Auto
|PMID=23596508
|Title=Alterations of Choroidal Blood Flow Regulation in Young Healthy Subjects with Complement Factor H Polymorphism
|OA=1
}}

{{PMID Auto
|PMID=23919682
|Title=Complement alternative pathway genetic variation and Dengue infection in the Thai population
|OA=1
}}

{{PMID Auto
|PMID=24080590
|Title=Genetic Association with Response to Intravitreal Ranibizumab for Neovascular Age-Related Macular Degeneration in the Han Chinese Population
}}

{{PMID Auto
|PMID=24332537
|Title=Incidence and Progression of Reticular Drusen in Age-Related Macular Degeneration: Findings from an Older Australian Cohort
}}

{{PMID Auto
|PMID=22875704
|Title=Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids.
|OA=1
}}

{{PMID Auto
|PMID=22936692
|Title=Can genetic associations change with age? CFH and age-related macular degeneration.
}}

{{PMID Auto
|PMID=23103884
|Title=Age-related macular degeneration and coronary heart disease: evaluation of genetic and environmental associations.
}}

{{PMID Auto
|PMID=23204795
|Title=Pharmacogenetic influence of LOC387715/HTRA1 on the efficacy of bevacizumab treatment for age-related macular degeneration in a Korean population.
|OA=1
}}

{{PMID Auto
|PMID=23289807
|Title=Gene-gene interactions of CFH and LOC387715/ARMS2 with Korean exudative age-related macular degeneration patients.
}}

{{PMID Auto
|PMID=23289808
|Title=The association of age-related maculopathy susceptibility 2 (ARMS2) and complement factor H (CFH) variants with two angiographic subtypes of polypoidal choroidal vasculopathy.
}}

{{PMID Auto
|PMID=23497844
|Title=Association of complement factor H tyrosine 402 histidine genotype with posterior involvement in sarcoid-related uveitis.
}}

{{PMID Auto
|PMID=23662819
|Title=Complement polymorphisms and cognitive dysfunction after carotid endarterectomy.
|OA=1
}}

{{PMID Auto
|PMID=23797962
|Title=Adrenomedullin Signaling Pathway Polymorphisms and Adverse Pregnancy Outcomes.
}}

{{PMID Auto
|PMID=24863099
|Title=Flicker-induced retinal vasodilatation is not dependent on complement factor H polymorphism in healthy young subjects
}}

{{PMID Auto
|PMID=24970616
|Title=The contribution of genetic factors to phenotype and progression of drusen in early age-related macular degeneration
}}

{{PMID Auto
|PMID=24067115
|Title=Functional effect of Saffron supplementation and risk genotypes in early age-related macular degeneration: a preliminary report
}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}