{{Rsnum
|rsid=1061622
|Gene=TNFRSF1B
|Chromosome=1
|position=12192898
|Orientation=plus
|ReferenceAllele=T
|MissenseAllele=G
|GMAF=0.197
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=TNFRSF1B
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 2.7 | 42.5 | 54.9
| HCB | 6.6 | 32.1 | 61.3
| JPT | 1.8 | 25.7 | 72.6
| YRI | 2.0 | 29.9 | 68.0
| ASW | 3.5 | 24.6 | 71.9
| CHB | 6.6 | 32.1 | 61.3
| CHD | 2.8 | 33.0 | 64.2
| GIH | 8.9 | 34.7 | 56.4
| LWK | 7.3 | 48.2 | 44.5
| MEX | 1.7 | 27.6 | 70.7
| MKK | 5.1 | 26.3 | 68.6
| TSI | 1.0 | 39.2 | 59.8
| HapMapRevision=28
}}{{PMID Auto
|PMID=19343543
|Title=Association analysis of TNFRSF1B polymorphisms with type 2 diabetes and its related traits in North India.
|OA=1
}}

{{PMID Auto
|PMID=19421420
|Title=Tumor Necrosis Factor Receptor Superfamily, Member 1B Haplotypes Increase or Decrease the Risk of Inflammatory Bowel Diseases in a New Zealand Caucasian Population
|OA=1
}}

{{PharmGKB
|RSID=rs1061622
|Name_s=TNFRSF1B: M196R
|Gene_s=TNFRSF1B
|Feature=
|Evidence=PubMed ID:18565259
|Annotation=For this SNP in the TNFRSF1B gene a significant correlation was found between 196R allele carriers and low response to infliximab therapy.
|Drugs=infliximab
|Drug Classes=
|Diseases=Arthritis, Rheumatoid
|Curation Level=Curated
|PharmGKB Accession ID=PA162191356
}}

{{PMID Auto
|PMID=19684152
|Title=Cigarette smoking, STAT4 and TNFRSF1B polymorphisms, and systemic lupus erythematosus in a Japanese population
}}

{{PMID Auto
|PMID=21995493
|Title=TNFRSF1B +676 T&gt;G polymorphism predicts survival of non-Small cell lung cancer patients treated with chemoradiotherapy
|OA=1
}}

{{PMID|15113403|OA=1
}} Current limitations of SNP data from the public domain for studies of complex disorders: a test for ten candidate genes for obesity and osteoporosis.

{{PMID|16109524}} Preparation and analysis of cSNP chip on hepatocellular carcinoma-related genes.

{{PMID|16380915|OA=1
}} Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4.

{{PMID|17705862|OA=1
}} Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.

{{PMID|18248655}} Genetic polymorphisms of tumour necrosis factor receptor superfamily 1A and 1B affect responses to infliximab in Japanese patients with Crohn's disease.

{{PMID|18385279}} The tumour necrosis factor receptor superfamily member 1b 676T>G polymorphism in relation to response to infliximab and adalimumab treatment and disease severity in rheumatoid arthritis.

{{PMID|18466472|OA=1
}} Constructing gene association networks for rheumatoid arthritis using the backward genotype-trait association (BGTA) algorithm.

{{PMID|18466513|OA=1
}} Evaluating gene x gene and gene x smoking interaction in rheumatoid arthritis using candidate genes in GAW15.

{{PMID|18603647|OA=1
}} Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.

{{PMID|18805939|OA=1
}} Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.

{{PMID|19401444|OA=1
}} Body iron stores and glucose intolerance in premenopausal women: role of hyperandrogenism, insulin resistance, and genomic variants related to inflammation, oxidative stress, and iron metabolism.

{{PMID|20007930|OA=1
}} A functional haplotype in the 3'untranslated region of TNFRSF1B is associated with tuberculosis in two African populations.

{{PMID|20018049|OA=1
}} Evaluation of an optimal receiver operating characteristic procedure.

{{PMID|20646319|OA=1
}} TNFRSF1B A1466G genotype is predictive of clinical efficacy after treatment with a definitive 5-fluorouracil/cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma.

{{PMID|20811626|OA=1
}} Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.

{{GET Evidence
|gene=TNFRSF1B
|aa_change=Met196Arg
|aa_change_short=M196R
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1061622
|overall_frequency_n=2493
|overall_frequency_d=10758
|overall_frequency=0.231735
|n_genomes=18
|n_genomes_annotated=0
|n_haplomes=19
|n_articles=1
|n_articles_annotated=1
|in_pharmgkb=Y
|pph2_score=0.986
|nblosum100=4
|autoscore=2
|webscore=N
|summary_short=Low response to Infliximab.
}}

{{PMID Auto
|PMID=22860894
|Title=Genetic polymorphisms of tumour necrosis factor receptor superfamily 1b and fas ligand are associated with clinical efficacy and/or acute severe infusion reactions to infliximab in Crohn's disease
}}

{{PMID Auto
|PMID=23799986
|Title=Maternal tumor necrosis factor receptor 2 gene variants associated with pre-eclampsia in Tunisian women
}}

{{PMID Auto
|PMID=22921902
|Title=The methionine 196 arginine polymorphism of the TNF receptor 2 gene (TNFRSF1B) is not associated with worse outcomes in heart failure.
|OA=1
}}

{{PMID Auto
|PMID=23238918
|Title=Genome-wide pathway analysis of a genome-wide association study on multiple sclerosis.
}}

{{PMID Auto
|PMID=25010932
|Title=Association of TNF-α, TNFRSF1A and TNFRSF1B Gene Polymorphisms with the Risk of Sporadic Breast Cancer in Northeast Chinese Han Women
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}