{{Rsnum
|rsid=1062613
|Gene=HTR3A
|Chromosome=11
|position=113975284
|Orientation=plus
|GMAF=0.2337
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=HTR3A
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 59.8 | 37.5 | 2.7
| HCB | 84.4 | 14.8 | 0.7
| JPT | 71.4 | 28.6 | 0.0
| YRI | 25.2 | 48.3 | 26.5
| ASW | 28.1 | 49.1 | 22.8
| CHB | 84.4 | 14.8 | 0.7
| CHD | 75.2 | 23.9 | 0.9
| GIH | 80.2 | 18.8 | 1.0
| LWK | 34.9 | 49.5 | 15.6
| MEX | 56.9 | 36.2 | 6.9
| MKK | 32.9 | 49.7 | 17.4
| TSI | 64.7 | 29.4 | 5.9
| HapMapRevision=28
}}

[[Rs1062613]] (C178T, Pro16Ser) is located within the 5' UTR of [[HTR3A]] and may effect HTR3A expression.

{{PMID|11505217}} reporter constructs containing the T allele showed increased HTR3A expression compared to the C allele

{{PMID|14557147}} CC and CT carriers associated with higher harm avoidance (p = 0.04) scores in 2 sample groups of Swedish women (366 in total), and non-conformity in 1 sample

{{PMID|18359159}} no significant association between treatment-resistant [[schizophrenia]] and [[Rs1062613]], however, maintenance neuroleptic dose was significantly higher for TT carriers (p = 0.041)

{{PharmGKB
|RSID=rs1062613
|Name_s=HTR3A:C178T; Pro16Ser
|Gene_s=HTR3A
|Feature=
|Evidence=PubMed ID:11505217; PubMed ID:18359159
|Annotation=This promoter variant regulates expression of the gene. The T allele is associated with increased expression.
|Drugs=
|Drug Classes=
|Diseases=Bipolar Disorder; Schizophrenia
|Curation Level=Curated
|PharmGKB Accession ID=PA162355761
}}

{{PMID Auto
|PMID=20168265
|Title=Influence of serotonin 3A and 3B receptor genes on clozapine treatment response in schizophrenia
}}

{{PMID Auto
|PMID=21420406
|Title=The HTR3A polymorphism c. -42C>T is associated with amygdala responsiveness in patients with irritable bowel syndrome.
|OA=1
}}

{{PMID Auto
|PMID=22700043
|Title=Outcome definitions and clinical predictors influence pharmacogenetic associations between HTR3A gene polymorphisms and response to clozapine in patients with schizophrenia
}}

{{PMID Auto
|PMID=23290502
|Title=Serotonin transporter and receptor genes significantly impact nicotine dependence through genetic interactions in both European American and African American smokers
|OA=1
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}