{{Rsnum
|rsid=1063499
|Gene=C7
|Chromosome=5
|position=40955459
|Orientation=minus
|ReferenceAllele=G
|MissenseAllele=C
|GMAF=0.4894
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=C7
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 13.3 | 54.9 | 31.9
| HCB | 17.6 | 54.4 | 27.9
| JPT | 26.5 | 49.6 | 23.9
| YRI | 48.3 | 42.9 | 8.8
| ASW | 49.1 | 40.4 | 10.5
| CHB | 17.6 | 54.4 | 27.9
| CHD | 15.6 | 41.3 | 43.1
| GIH | 26.7 | 40.6 | 32.7
| LWK | 49.1 | 36.4 | 14.5
| MEX | 12.1 | 56.9 | 31.0
| MKK | 33.3 | 47.4 | 19.2
| TSI | 11.9 | 58.4 | 29.7
| HapMapRevision=28
}}{{Venter SNP
|rsid=1063499
|allele=C
|frequency=0.6
|uid=1103654083810
|type=homozygous_SNP
|hugo=C7
|ensembl gene=ENSG00000112936
|ensembl transcript=ENST00000313164
|sift=TOLERATED
|disease=Defects in C7 are a cause of component C7 deficiency (C7D) (MIM:217070). Patients with C7D suffer from recurrent bacterial infections, predominantly from Neisseria meningitidis.
}}

{{PMID Auto
|PMID=19221116
|Title=Use of a genetic isolate to identify rare disease variants: C7 on 5p associated with MS.
|OA=1
}}

{{PMID Auto
|PMID=19344414
|Title=Risk of non-Hodgkin lymphoma in association with germline variation in complement genes.
|OA=1
}}

{{GET Evidence
|gene=C7
|aa_change=Ser389Thr
|aa_change_short=S389T
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1063499
|overall_frequency_n=5135
|overall_frequency_d=9760
|overall_frequency=0.526127
|n_genomes=40
|n_genomes_annotated=0
|n_haplomes=57
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.986
|nblosum100=-2
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Affy500k}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}