{{Rsnum
|rsid=1065489
|Gene=CFH
|Chromosome=1
|position=196740644
|Orientation=plus
|GMAF=0.2332
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=CFH
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 72.3 | 23.2 | 4.5
| HCB | 24.1 | 45.3 | 30.7
| JPT | 28.3 | 49.6 | 22.1
| YRI | 95.2 | 4.8 | 0.0
| ASW | 84.2 | 15.8 | 0.0
| CHB | 24.1 | 45.3 | 30.7
| CHD | 27.5 | 39.4 | 33.0
| GIH | 81.2 | 16.8 | 2.0
| LWK | 91.8 | 8.2 | 0.0
| MEX | 52.6 | 35.1 | 12.3
| MKK | 76.9 | 21.2 | 1.9
| TSI | 66.7 | 30.4 | 2.9
| HapMapRevision=28
}}{{PMID Auto
|PMID=19162324
|Title=Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis
}} Each copy of the less common T version of this SNP was associated with about 36% lower odds of meningococcal disease.

{{omim
|desc=COMPLEMENT FACTOR H-RELATED 3; CFHR3
|id=605336
|rsnum=1065489
}}

{{omim
|id=134370
|rsnum=1065489
}}

{{PMID Auto
|PMID=17022693
|Title=Determination of complement factor H functional polymorphisms (V62I, Y402H, and E936D) using sequence-specific primer PCR and restriction fragment length polymorphisms.
}}

{{PMID Auto
|PMID=18483746
|Title=Plasma therapy in atypical haemolytic uremic syndrome: lessons from a family with a factor H mutation.
|OA=1
}}

{{PMID Auto
|PMID=19187823
|Title=Coding variant I62V in the complement factor H gene is strongly associated with polypoidal choroidal vasculopathy.
}}

{{PMID Auto
|PMID=19861685
|Title=Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome.
|OA=1
}}

{{PMID Auto
|PMID=19958499
|Title=A particle swarm based hybrid system for imbalanced medical data sampling.
|OA=1
}}

{{PMID Auto
|PMID=20694013
|Title=Genome-wide association study identifies variants in the CFH region associated with host susceptibility to meningococcal disease.
}}

{{GET Evidence
|gene=CFH
|aa_change=Glu936Asp
|aa_change_short=E936D
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1065489
|overall_frequency_n=1493
|overall_frequency_d=10758
|overall_frequency=0.13878
|n_genomes=15
|n_genomes_annotated=0
|n_haplomes=17
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|pph2_score=0.504
|genetests_testable=Y
|genetests_reviewed=Y
|nblosum100=-2
|autoscore=3
|n_web_uneval=10
}}

{{PMID Auto
|PMID=23423485
|Title=Genetic variants of complement genes ficolin-2, mannose-binding lectin and complement factor H are associated with leprosy in Han Chinese from Southwest China
}}

{{PMID Auto
|PMID=24365176
|Title=Common variants in the complement factor H gene confer genetic susceptibility to central serous chorioretinopathy
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}