{{Rsnum
|rsid=10735781
|Gene=EVI5
|Chromosome=1
|position=92655550
|Orientation=plus
|GMAF=0.3535
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=EVI5
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 42.5 | 46.0 | 11.5
| HCB | 86.1 | 13.1 | 0.7
| JPT | 90.3 | 8.8 | 0.9
| YRI | 10.9 | 40.8 | 48.3
| ASW | 19.3 | 54.4 | 26.3
| CHB | 86.1 | 13.1 | 0.7
| CHD | 78.9 | 20.2 | 0.9
| GIH | 61.4 | 33.7 | 5.0
| LWK | 8.2 | 44.5 | 47.3
| MEX | 51.7 | 41.4 | 6.9
| MKK | 12.8 | 42.9 | 44.2
| TSI | 44.1 | 43.1 | 12.7
| HapMapRevision=28
}}[[rs10735781]] has been reported in a large study to be associated with [[multiple sclerosis]].

The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with this allele is 1.11 (CI 1.05-1.18). {{PMID|17660530}}

{{PharmGKB
|RSID=rs10735781
|Name_s=
|Gene_s=EVI5
|Feature=
|Evidence=PubMed ID:17660530
|Annotation=In a replicated GWAS of U.K. and U.S. case/parent trios, this variant was shown to be associated with multiple sclerosis risk.
|Drugs=
|Drug Classes=
|Diseases=Multiple Sclerosis
|Curation Level=Curated
|PharmGKB Accession ID=PA162356169
}}

{{PMID Auto
|PMID=19865102
|Title=Multiple sclerosis susceptibility alleles in African Americans
|OA=1
}}

{{PMID|20546594|OA=1
}} An application of Random Forests to a genome-wide association dataset: methodological considerations & new findings.

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10735781
|overall_frequency_n=73
|overall_frequency_d=128
|overall_frequency=0.570312
|n_genomes=45
|n_genomes_annotated=0
|n_haplomes=63
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}