{{Rsnum
|rsid=10741657
|Gene=CYP2R1
|Chromosome=11
|position=14893332
|Orientation=plus
|GMAF=0.3338
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=CYP2R1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 15.6 | 45.3 | 39.1
| HCB | 12.8 | 46.2 | 41.0
| JPT | 15.9 | 47.7 | 36.4
| YRI | 1.7 | 40.7 | 57.6
| ASW | 0.0 | 0.0 | 0.0
| CHB | 12.8 | 46.2 | 41.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}[[rs10741657]], located near the cytochrome P450, family 2, subfamily R, polypeptide 1 [[CYP2R1]] gene on chromosome 11p15, has been linked by several studies to vitamin D serum concentrations.

In both studies, the allele associated with lower vitamin D, and thus the potential for [[vitamin D insufficiency]], is [[rs10741657]](G). Carriers of two such alleles have lower vitamin D than carriers of one allele, who in turn on average have lower vitamin D levels than [[rs10741657]](A;A) individuals.{{PMID|20541252|OA=1
}}

{{PMID|21431378|OA=1
}} The 'A' allele of CYP2R1 rs10741657 was associated with increased 25(OH)D levels in a study of vitamin D levels and MS risk in 1,655 cases and 6,349 controls.

{{PMID Auto GWAS
|PMID=20541252
|Trait=Vitamin D insufficiency
|Title=Common genetic determinants of vitamin D insufficiency: a genome-wide association study.
|RiskAllele=
|Pval=3E-20
|OR=None
|ORtxt=None
|OA=1
}}{{PMID Auto
|PMID=17607662
|Title=CYP2R1 (vitamin D 25-hydroxylase) gene is associated with susceptibility to type 1 diabetes and vitamin D levels in Germans.
}}

{{PMID Auto
|PMID=19783860
|Title=A rare haplotype of the vitamin D receptor gene is protective against diabetic nephropathy.
}}

{{PMID Auto
|PMID=22559001
|Title=Impaired Vitamin D activation and association with CYP24A1 haplotypes in differentiated thyroid carcinoma.
}}

{{PMID Auto
|PMID=22583563
|Title=Genetic and environmental predictors of serum 25-hydroxyvitamin D concentrations among middle-aged and elderly Chinese in Singapore.
|OA=1
}}

{{PMID Auto
|PMID=22690899
|Title=Impaired Vitamin D Activation and Association with CYP24A1 Haplotypes in Differentiated Thyroid Carcinoma.
|OA=1
}}
{{PMID Auto
|PMID=22701574
|Title=Instrumental variable estimation of the causal effect of plasma 25-hydroxy-vitamin D on colorectal cancer risk: a mendelian randomization analysis
|OA=1
}}
{{PMID Auto
|PMID=23416105
|Title=Vitamin D status and gene transcription in immune cells
}}
{{PMID Auto
|PMID=23734184
|Title=Genetic Analyses Reveal a Role for Vitamin D Insufficiency in HCV-Associated Hepatocellular Carcinoma Development
|OA=1
}}
{{PMID Auto
|PMID=23924835
|Title=Genetic variant in vitamin D binding protein is associated with serum 25-hydroxyvitamin D and vitamin D insufficiency in southern Chinese
}}{{PMID Auto
|PMID=22673963
|Title=Genome-wide association analysis of circulating vitamin D levels in children with asthma.
|OA=1
}}

{{PMID Auto
|PMID=22740028
|Title=An exploratory analysis of common genetic variants in the vitamin D pathway including genome-wide associated variants in relation to glioma risk and outcome.
|OA=1
}}

{{PMID Auto
|PMID=22801813
|Title=The GC, CYP2R1 and DHCR7 genes are associated with vitamin D levels in northeastern Han Chinese children.
}}

{{PMID Auto
|PMID=23319826
|Title=Vitamin D and mortality: a Mendelian randomization study.
}}

{{PMID Auto
|PMID=23730842
|Title=Association of vitamin D serum levels and its common genetic determinants, with severity of liver fibrosis in genotype 1 chronic hepatitis C patients.
}}

{{PMID Auto
|PMID=23793229
|Title=Association of common gene variants in vitamin D modulating genes and colon cancer recurrence.
}}
{{PMID Auto
|PMID=25003556
|Title=Triangular relationship between single nucleotide polymorphisms in the CYP2R1 gene (rs10741657 and rs12794714), 25-hydroxyvitamin d levels, and coronary artery disease incidence
}}