{{Rsnum
|rsid=10748842
|Gene=NRG3
|Chromosome=10
|position=83649739
|Orientation=plus
|GMAF=0.1084
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=131
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}
{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 0.9 | 16.8 | 82.3
| HCB | 0.0 | 10.2 | 89.8
| JPT | 0.0 | 8.8 | 91.2
| YRI | 4.1 | 25.2 | 70.7
| ASW | 1.8 | 26.3 | 71.9
| CHB | 0.0 | 10.2 | 89.8
| CHD | 0.0 | 13.0 | 87.0
| GIH | 2.0 | 31.7 | 66.3
| LWK | 2.7 | 30.9 | 66.4
| MEX | 1.7 | 17.2 | 81.0
| MKK | 1.3 | 23.7 | 75.0
| TSI | 0.0 | 14.7 | 85.3
| HapMapRevision=28
}}[[rs10748842]] is a SNP in the neuregulin 3 [[NRG3]] gene.

Based on a study of 1515 [[Ashkenazi]] Jewish individuals, including 285 parent-child trios, 173 unrelated cases, and 487 unrelated controls, three SNPs ([[rs10883866]], [[rs10748842]], and [[rs6584400]]) were found to be associated with the "delusion" factor as a quantitative trait in [[schizophrenia]], even though no SNP in this study withstood multiple test correction for association with the binary schizophrenia phenotype itself. After replication in an independent set of 153 Ashkenazi Jewish samples, the empirical study-wide significance across all 9 factors studied was estimated to be p = 2.7x10e-3.{{PMID|19118813|OA=1
}}

{{PharmGKB
|RSID=rs10748842
|Name_s=
|Gene_s=NRG3
|Feature=
|Evidence=PubMed ID:19118813
|Annotation=In a study of Ashkenazi Jewish SZ (schizophrenia and schizoaffective disorder),the minor allele (C) of rs10748842 was found to be associated with the "delusion" factor (285 parent-child trios,173 unrelated cases, and 458 unrelated controls;combined p = 2.30 x 10(-7).)
|Drugs=
|Drug Classes=
|Diseases=Schizophrenia
|Curation Level=Curated
|PharmGKB Accession ID=PA165106877
}}

{{PMID Auto
|PMID=20713722
|Title=Common genetic variation in Neuregulin 3 (NRG3) influences risk for schizophrenia and impacts NRG3 expression in human brain
|OA=1
}}

{{omim
|id=605533
|desc=NEUREGULIN 3; NRG3
|rsnum=10748842
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10748842
|overall_frequency_n=20
|overall_frequency_d=128
|overall_frequency=0.15625
|n_genomes=14
|n_genomes_annotated=0
|n_haplomes=17
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}