{{Rsnum
|rsid=10761659
|Chromosome=10
|position=64445564
|Orientation=plus
|GMAF=0.4982
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=131
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}
{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 15.9 | 57.5 | 26.5
| HCB | 5.1 | 31.4 | 63.5
| JPT | 6.2 | 45.1 | 48.7
| YRI | 93.9 | 6.1 | 0.0
| ASW | 77.2 | 21.1 | 1.8
| CHB | 5.1 | 31.4 | 63.5
| CHD | 4.6 | 30.3 | 65.1
| GIH | 16.8 | 37.6 | 45.5
| LWK | 79.1 | 20.9 | 0.0
| MEX | 13.8 | 43.1 | 43.1
| MKK | 76.3 | 22.4 | 1.3
| TSI | 24.5 | 49.0 | 26.5
| HapMapRevision=28
}}[[rs10761659]] has been reported in a large study to be associated with [[Crohn's disease]].

The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 1.23 (CI 1.05-1.45), and for homozygotes, 1.55 (CI 1.3-1.84). {{PMID|17554300|OA=1
}}

{{PMID Auto
|PMID=19174780
|Title=Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort
}}

{{omim
|desc=INFLAMMATORY BOWEL DISEASE 15; IBD15
|id=612255
|rsnum=10761659
}}

{{PMID Auto GWAS
|PMID=21102463
|Trait=None
|Title=Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
|RiskAllele=G
|Pval=4E-22
|OR=1.2300
|ORtxt=[1.18-1.29]
|OA=1
}}

{{PMID Auto
|PMID=18224312
|Title=Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.
|OA=1
}}

{{PMID Auto
|PMID=18438406
|Title=Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.
|OA=1
}}

{{PMID Auto
|PMID=18533027
|Title=Worldwide population differentiation at disease-associated SNPs.
|OA=1
}}

{{PMID Auto
|PMID=18853133
|Title=Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=18936107
|Title=Positive association of genetic variants in the upstream region of NKX2-3 with Crohn's disease in Japanese patients.
}}

{{PMID Auto
|PMID=20846217
|Title=Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10761659
|overall_frequency_n=58
|overall_frequency_d=128
|overall_frequency=0.453125
|n_genomes=29
|n_genomes_annotated=0
|n_haplomes=46
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=23128233
  |Trait=Inflammatory bowel disease
  |Title=Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
  |RiskAllele=G
  |Pval=6E-46
  |OR=1.17
  |ORtxt=[1.134-1.20]
  |OA=1
}}

{{PMID Auto GWAS
  |PMID=22936669
  |Trait=Crohn's disease
  |Title=A genome-wide association study on a southern European population identifies a new Crohn's disease susceptibility locus at RBX1-EP300.
  |RiskAllele=G
  |Pval=5E-6
  |OR=1.28
  |ORtxt=[NR]
  }}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}