{{Rsnum
|rsid=1076560
|Gene=DRD2
|Chromosome=11
|position=113412966
|Orientation=plus
|GMAF=0.2149
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=DRD2
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 1.8 | 22.3 | 75.9
| HCB | 21.2 | 44.5 | 34.3
| JPT | 15.0 | 52.2 | 32.7
| YRI | 2.1 | 13.7 | 84.2
| ASW | 0.0 | 22.8 | 77.2
| CHB | 21.2 | 44.5 | 34.3
| CHD | 17.6 | 54.6 | 27.8
| GIH | 9.9 | 34.7 | 55.4
| LWK | 0.9 | 14.7 | 84.4
| MEX | 10.3 | 55.2 | 34.5
| MKK | 0.0 | 24.0 | 76.0
| TSI | 2.0 | 22.5 | 75.5
| HapMapRevision=28
}}{{neighbor
| rsid = 1801028
| distance = 204
}}{{ neighbor
| rsid = 1800496
| distance = 200
}}
[[rs1076560]] is located in intron 6 of the dopamine receptor D2 gene.

In one study of Japanese males, [[rs1076560]](A) alleles were 1.3 fold more associated with [[Alcoholism]] than the [[rs1076560]](C) alleles. {{PMID|17196743}}

The [[DRD2]] risk allele A was more prevalent in the alcoholic patients than in the healthy controls. These data identify [[rs1076560]] as a potentially important variable in the development of [[alcoholism]].

{{PMID|19176830|OA=1
}} rs1076560 and the DAT 3'-VNTR variant influences [[memory]]

{{PMID|19373123}} Genetic variants altering dopamine D2 receptor expression or function modulate the risk of opiate [[addiction]] and the dosage requirements of methadone substitution

{{PMID Auto
|PMID=19796663
|Title=Influence of DRD2 and ANKK1 genotypes on apomorphine-induced growth hormone (GH) response in alcohol-dependent patients
}}

{{PMID Auto
|PMID=19940176
|Title=Functional Variation of the Dopamine D2 Receptor Gene Is Associated with Emotional Control as well as Brain Activity and Connectivity during Emotion Processing in Humans
|OA=1
}}

{{PharmGKB
|RSID=rs1076560
|Name_s=
|Gene_s=DRD2
|Feature=
|Evidence=PubMed ID:17196743
|Annotation=This variant is a potential marker for alcoholism. A allele was more prevalent in the alcoholic patients than in the healthy controls in a study consists of 248 alcoholic patients and 322 healthy controls (all Japanese males).
|Drugs=ethanol
|Drug Classes=
|Diseases=Alcoholism
|Curation Level=Curated
|PharmGKB Accession ID=PA162360621
}}

{{PMID Auto
|PMID=19512960
|Title=Genetic diagnostics of functional variants of the human dopamine D2 receptor gene
}}

{{PMID Auto
|PMID=20179754
|Title=Genetically Determined Measures of Striatal D2 Signaling Predict Prefrontal Activity during Working Memory Performance
|OA=1
}}

{{PMID Auto
|PMID=19393722 
|Title=  Genetic contributions to avoidance-based decisions: striatal D2 polymorphisms
|OA=1
}}

{{PharmGKB
|RSID=rs1076560
|Name_s=
|Gene_s=DRD2
|Feature=
|Evidence=PubMed ID:18077375; PubMed ID:18829695
|Annotation=This variant is in intron 6, and T allele shifts mRNA splicing from the short form (D2S) to the long form (D2L). The T allele carriers are also associated with reduced working memory and attension perfermance.
|Drugs=
|Drug Classes=
|Diseases=Schizophrenia
|Curation Level=Curated
|PharmGKB Accession ID=PA162355758
}}
{{PMID Auto
|PMID=21087673
|Title=D2 receptor genotype and striatal dopamine signaling predict motor cortical activity and behavior in humans
}}

{{PMID Auto
|PMID=21150907
|Title=Intronic polymorphisms affecting alternative splicing of human dopamine D2 receptor are associated with cocaine abuse.
|OA=1
}}

{{PMID Auto
|PMID=22569179
|Title=Rs1076560, a functional variant of the dopamine D2 receptor gene, confers risk of schizophrenia in Han Chinese
}}

{{PMID Auto
|PMID=22745721
|Title=Cannabis-Dependence Risk Relates to Synergism between Neuroticism and Proenkephalin SNPs Associated with Amygdala Gene Expression: Case-Control Study
|OA=1
}}

{{PMID Auto
|PMID=18077373
|Title=Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory.
|OA=1
}}

{{PMID Auto
|PMID=19321766
|Title=Dopamine DRD2 polymorphism alters reversal learning and associated neural activity.
|OA=1
}}

{{PMID Auto
|PMID=20146828
|Title=Dopamine D2 receptor polymorphisms and susceptibility to alcohol dependence in Indian males: a preliminary study.
|OA=1
}}

{{PMID Auto
|PMID=20617039
|Title=Alcoholism and alternative splicing of candidate genes.
|OA=1
}}

{{PMID Auto
|PMID=21187413
|Title=DRD2/AKT1 interaction on D2 c-AMP independent signaling, attentional processing, and response to olanzapine treatment in schizophrenia.
|OA=1
}}

{{PMID Auto
|PMID=21645585
|Title=Resting posterior minus frontal EEG slow oscillations is associated with extraversion and DRD2 genotype.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1076560
|overall_frequency_n=24
|overall_frequency_d=128
|overall_frequency=0.1875
|n_genomes=15
|n_genomes_annotated=0
|n_haplomes=18
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=24322206
|Title=Contrasting changes in DRD1 and DRD2 splice variant expression in schizophrenia and affective disorders, and associations with SNPs in postmortem brain
}}

{{PMID Auto
|PMID=24359476
|Title=The Dopamine Receptor D2 (DRD2) SNP rs1076560 is Associated with Opioid Addiction
}}

{{PMID Auto
|PMID=24424781
|Title=DRD2 genotype predicts prefrontal activity during working memory after stimulation of D2 receptors with bromocriptine
}}

{{PMID Auto
|PMID=21976709
|Title=DRD2 genotype-based variation of default mode network activity and of its relationship with striatal DAT binding.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}