{{Rsnum
|rsid=10778213
|Chromosome=12
|position=103101373
|Orientation=plus
|GMAF=0.3274
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 24.8 | 53.1 | 22.1
| HCB | 71.5 | 26.3 | 2.2
| JPT | 56.6 | 41.6 | 1.8
| YRI | 56.5 | 42.9 | 0.7
| ASW | 50.9 | 47.4 | 1.8
| CHB | 71.5 | 26.3 | 2.2
| CHD | 73.1 | 24.1 | 2.8
| GIH | 17.8 | 52.5 | 29.7
| LWK | 56.0 | 36.7 | 7.3
| MEX | 43.1 | 48.3 | 8.6
| MKK | 41.9 | 40.0 | 18.1
| TSI | 23.5 | 39.2 | 37.3
| HapMapRevision=28
}}{{GWAS Summary
|SNP=rs10778213
|PubMedID=18439548
|Condition=C-reactive protein
|Gene=Unknown
|Risk Allele=G
|pValue=1.00E-010
|OR=0.12
|95CI=NR) mg/dl decreas
|OA=1
}}

{{PharmGKB
|RSID=rs10778213
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18439548; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Loci Related to Metabolic-Syndrome Pathways Including LEPR, HNF1A, IL6R, and GCKR Associate with Plasma C-Reactive Protein: The Women's Genome Health Study (Initial Sample Size: 6,345 women; Replication Sample Size: NR; Risk Allele: rs10778213-G). This variant is associated with C-reactive protein levels.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus; Metabolic Syndrome X; Myocardial Infarction; Stroke
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356791
}}

{{PharmGKB
|RSID=rs10778213
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18439548
|Annotation=In a GWAS of apparently healthy women, seven loci were found to be significantly associated with C-Reactive protein levels. Two SNPs in an intergenic region (12q23.2) were significantly associated with CRP, and of those, this was the most significantly associated.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA161614222
}}

{{PMID Auto
|PMID=18852197
|Title=Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.
|OA=1
}}

{{PMID Auto
|PMID=19060910
|Title=Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.
|OA=1
}}

{{PMID Auto
|PMID=19936222
|Title=Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.
|OA=1
}}

{{PMID Auto
|PMID=20031577
|Title=Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.
|OA=1
}}

{{PMID Auto
|PMID=21647738
|Title=Genome-wide association with C-reactive protein levels in CLHNS: evidence for the CRP and HNF1A loci and their interaction with exposure to a pathogenic environment.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10778213
|overall_frequency_n=75
|overall_frequency_d=128
|overall_frequency=0.585938
|n_genomes=47
|n_genomes_annotated=0
|n_haplomes=67
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}