{{Rsnum
|rsid=10795668
|Chromosome=10
|position=8701219
|Orientation=plus
|GMAF=0.27
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=131
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}
{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 9.8 | 45.5 | 44.6
| HCB | 11.8 | 46.3 | 41.9
| JPT | 22.3 | 41.1 | 36.6
| YRI | 0.0 | 2.1 | 97.9
| ASW | 0.0 | 8.8 | 91.2
| CHB | 11.8 | 46.3 | 41.9
| CHD | 13.9 | 48.1 | 38.0
| GIH | 8.1 | 41.4 | 50.5
| LWK | 0.0 | 4.5 | 95.5
| MEX | 14.0 | 52.6 | 33.3
| MKK | 0.0 | 0.0 | 0.0
| TSI | 7.8 | 41.2 | 51.0
| HapMapRevision=28
}}

[[rs10795668]] is a SNP within chromosomal region 10p14. It has been reported in several publications as being associated with higher risk for [[colorectal cancer]].

In a replication study of ~1,800 Swedish patients, the [[rs10795668]](G) allele was specifically also shown to be associated with younger age of onset for [[colorectal cancer]] and with sporadic cases.{{PMID|20648012|OA=1
}} Note that this conflicts with the earlier GWAS reports concluding that the risk allele is [[rs10795668]](A).

{{GWAS Summary
|SNP=rs10795668
|PubMedID=18372905
|Condition=Colorectal cancer
|Gene=Intergenic
|Risk Allele=A
|pValue=3.00E-013
|OR=1.12
|95CI=1.10-1.16
}}

{{omim
|desc=COLORECTAL CANCER, SUSCEPTIBILITY TO, 5; CRCS5
|id=612230
|rsnum=10795668
}}
{{PMID Auto
|PMID=19843678
|Title=Enrichment of Low Penetrance Susceptibility Loci in a Dutch Familial Colorectal Cancer Cohort
}}

{{PharmGKB
|RSID=rs10795668
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18372905; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: A genome-wide association study identifies colorectal cancer susceptibility loci on chromosome 10p14 and 8q23.3 (Initial Sample Size: 922 cases, 927 controls; Replication Sample Size: 17,872 cases, 17,526 controls; Risk Allele: rs10795668-A).
|Drugs=
|Drug Classes=
|Diseases=Colorectal Neoplasms
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356769
}}

{{PMID Auto
|PMID=20530476
|Title=Risk of Genome-Wide Association Study-Identified Genetic Variants for Colorectal Cancer in a Chinese Population
}}
{{PMID Auto
|PMID=20659471
|Title=Genetic Heterogeneity in Colorectal Cancer Associations in Americans of African vs. European Descent
|OA=1
}}
{{PMID Auto
|PMID=21097774
|Title=Colorectal cancer susceptibility loci on chromosome 8q23.3 and 11q23.1 as modifiers for disease expression in lynch syndrome
}}
{{PMID Auto
|PMID=21119214
|Title=Colorectal Cancer Susceptibility Loci in a Population-Based Study: Associations with Morphological Parameters
|OA=1
}}
{{PMID Auto
|PMID=21179028
|Title=Replication study of SNP associations for colorectal cancer in Hong Kong Chinese
|OA=1
}}

{{PMID Auto
|PMID=22367214
|Title=Characterization of gene-environment interactions for colorectal cancer susceptibility loci
|OA=1
}}

{{PMID Auto
|PMID=22363440
|Title=cis-Expression QTL Analysis of Established Colorectal Cancer Risk Variants in Colon Tumors and Adjacent Normal Tissue
|OA=1
}}

{{PMID Auto
|PMID=22457859
|Title=Single nucleotide polymorphisms in colorectal cancer: associations with tumor site and TNM stage
}}

{{PMID Auto
|PMID=19011631
|Title=Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer.
|OA=1
}}

{{PMID Auto
|PMID=20501757
|Title=Low-penetrance susceptibility variants in familial colorectal cancer.
|OA=1
}}

{{PMID Auto
|PMID=21071539
|Title=Generalizability and epidemiologic characterization of eleven colorectal cancer GWAS hits in multiple populations.
|OA=1
}}

{{PMID Auto
|PMID=21314996
|Title=Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci.
|OA=1
}}

{{PMID Auto
|PMID=21402474
|Title=GWAS-identified colorectal cancer susceptibility locus associates with disease prognosis.
}}

{{PMID Auto
|PMID=22045029
|Title=Relationship between 16 susceptibility loci and colorectal cancer phenotype in 3146 patients.
}}

{{PMID Auto
|PMID=22235025
|Title=Susceptibility genetic variants associated with early-onset colorectal cancer.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10795668
|overall_frequency_n=35
|overall_frequency_d=128
|overall_frequency=0.273438
|n_genomes=24
|n_genomes_annotated=0
|n_haplomes=30
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23359760
|Title=Single-nucleotide polymorphism associations for colorectal cancer in southern chinese population
|OA=1
}}

{{PMID Auto
|PMID=23712746
|Title=GENETIC SUSCEPTIBILITY VARIANTS ASSOCIATED WITH COLORECTAL CANCER PROGNOSIS
}}

{{PMID Auto
|PMID=23717594
|Title=The Genetic Variant on Chromosome 10p14 Is Associated with Risk of Colorectal Cancer: Results from a Case-Control Study and a Meta-Analysis
|OA=1
}}

{{PMID Auto
|PMID=23875689
|Title=Colorectal Cancer-Susceptibility Single Nucleotide Polymorphisms in Korean Population
}}

{{PMID Auto
|PMID=22848671
|Title=Association of eleven common, low-penetrance colorectal cancer susceptibility genetic variants at six risk loci with clinical outcome.
|OA=1
}}

{{PMID Auto
|PMID=22999960
|Title=Much of the genetic risk of colorectal cancer is likely to be mediated through susceptibility to adenomas.
|OA=1
}}

{{PMID Auto
|PMID=23434150
|Title=Are the common genetic variants associated with colorectal cancer risk for DNA mismatch repair gene mutation carriers?
|OA=1
}}

{{PMID Auto
|PMID=24801760
|Title=Common colorectal cancer risk alleles contribute to the multiple colorectal adenoma phenotype, but do not influence colonic polyposis in FAP
}}

{{PMID Auto
|PMID=24875374
|Title=Variation in the Association Between Colorectal Cancer Susceptibility Loci and Colorectal Polyps by Polyp Type
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}