{{Rsnum
|rsid=10811661
|Chromosome=9
|position=22134095
|Orientation=plus
|GMAF=0.2062
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 5.3 | 29.2 | 65.5
| HCB | 22.6 | 43.8 | 33.6
| JPT | 19.6 | 57.1 | 23.2
| YRI | 0.0 | 4.8 | 95.2
| ASW | 0.0 | 17.5 | 82.5
| CHB | 22.6 | 43.8 | 33.6
| CHD | 20.2 | 52.3 | 27.5
| GIH | 0.0 | 18.8 | 81.2
| LWK | 1.8 | 8.2 | 90.0
| MEX | 1.7 | 15.5 | 82.8
| MKK | 2.6 | 17.2 | 80.1
| TSI | 4.9 | 27.5 | 67.6
| HapMapRevision=28
}}{{PMID|18477659}} [[rs10811661]] replicated as significant for type-2 diabetes risk in 1,900 Japanese patients, with odds ratio of 1.27 (CI: 1.15-1.40, p = 1.9 x 10e-6)

[[rs10811661]] is mentioned in [http://suicyte.wordpress.com/2007/05/28/soul-searching-ii/ part 2 of a series]

{{PMID|18162508}} significantly associated with [[type-2 diabetes]] p = 0.0024; in 1,630 Japanese subjects with [[type-2 diabetes]] and in 1,064 controls

{{PMID|18437351}} 1,638 [[type 2 diabetes]] patients and 1,858 controls
*[[rs10811661]] in the vicinity of CDKN2B (OR 1.20, 95% CI: 1.06-1.37, p = 0.004)

{{PMID|18461161|OA=1
}} T2D and normal glucose tolerant (NGT) individuals. (3,295 T2D and 3,595 NGT), strong associations with T2D were found for 
*CDKAL1 (OR([[rs7756992]]) = 1.30[1.19-1.42], P = 2.3x10(-9))
*CDKN2A/2B (OR([[rs10811661]]) = 0.74[0.66-0.82], P = 3.5x10(-8))
*IGFBP2 (OR([[rs1470579]]) = 1.17[1.07-1.27], P = 0.0003) SNPs. 
T2D risk increased strongly when risk alleles, including the previously discovered T2D-associated TCF7L2 [[rs7903146]] SNP, were combined (8.68-fold for the 14% of French individuals carrying 18 to 30 risk alleles with an allelic OR of 1.24)

{{PMID|18368387}} Association between [r[s10811661]] and [[type-2 diabetes]] was replicated in a French Europid population, with an odds ratio of 1.43 (CI: 1.24-1.64, p = 3.8 x 10e-7).

{{PMID|19033397|OA=1
}} This SNP was confirmed to be associated with [[type-2 diabetes]] in a study of 500+ Japanese patients plus pooled meta-analysis with 6 previous association studies (also of Japanese).

{{ neighbor
| rsid = 1333049
| distance = 8591
}}

{{GWAS Summary
|SNP=rs10811661
|PubMedID=17463249
|Condition=Type 2 diabetes
|Gene=CDKN2A/B
|Risk Allele=T
|pValue=8.00E-015
|OR=1.2
|95CI=1.14-1.25
|OA=1
}}
{{PMID Auto
|PMID=19258437
|Title=A Genetic Variant in the IGF2BP2 Gene may Interact with Fetal Malnutrition on Glucose Metabolism.
|OA=1
}}

{{PMID Auto GWAS
|PMID=19056611
|Trait=Type 2 diabetes
|Title=Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome wide association data
|RiskAllele=
|Pval=7E-7
|OR=1.26
|ORtxt=[1.15-1.38]
|OA=1
}}
{{PMID Auto GWAS
|PMID=17463246
|Trait=Type 2 diabetes
|Title=Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
|RiskAllele=T
|Pval=8.0000000000000006E-15
|OR=1.20
|ORtxt=[1.14-1.25]
}}
{{PMID Auto GWAS
|PMID=17463248
|Trait=Type 2 diabetes
|Title=A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
|RiskAllele=T
|Pval=8.0000000000000006E-15
|OR=1.20
|ORtxt=[1.14-1.25]
|OA=1
}}
{{PMID Auto
|PMID=19463184
|Title=Worldwide patterns of haplotype diversity at 9p21.3, a locus associated with type 2 diabetes and coronary heart disease
|OA=1
}}

{{omim
|desc=DIABETES MELLITUS, NONINSULIN-DEPENDENT; NIDDM
|id=125853
|rsnum=10811661
}}

{{omim
|desc=AORTIC ANEURYSM, FAMILIAL ABDOMINAL 3
|id=611891
|rsnum=10811661
}}

{{omim
|desc=ANEURYSM, INTRACRANIAL BERRY, 6
|id=611892
|rsnum=10811661
}}

{{omim
|desc=CYCLIN-DEPENDENT KINASE INHIBITOR 2A; CDKN2A
|id=600160
|rsnum=10811661
}}

{{omim
|desc=CYCLIN-DEPENDENT KINASE INHIBITOR 2B; CDKN2B
|id=600431
|rsnum=10811661
}}

{{PharmGKB
|RSID=rs10811661
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19056611; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome wide association data. (Initial Sample Size: 1,924 cases, 2,938 controls; Replication Sample Size: 3,757 cases, 5,346 controls); (Region: 9p21.3; Reported Gene(s): CDKN2B; Risk Allele: rs10811661-?); (p-value= 0.0000007).This variant is associated with Type 2 diabetes.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus; Diabetes Mellitus, Type 2
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740298
}}
{{PMID Auto
|PMID=20018066
|Title=Epistatic interactions of CDKN2B-TCF7L2 for risk of type 2 diabetes and of CDKN2B-JAZF1 for triglyceride/high-density lipoprotein ratio longitudinal change: evidence from the Framingham Heart Study
|OA=1
}}
{{PMID Auto
|PMID=20043145
|Title=Improvements in glucose homeostasis in response to regular exercise are influenced by the PPARG Pro12Ala variant: results from the HERITAGE Family Study
|OA=1
}}

{{PMID Auto
|PMID=20802253
|Title=Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion
|OA=1
}}

{{PharmGKB
|RSID=rs10811661
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:17463246
|Annotation=rs10811661 demonstrated association with Type 2 Diabetes in a GWAS of Finnish and Swedish patients and controls.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus, Type 2
|Curation Level=Curated
|PharmGKB Accession ID=PA162168094
}}

{{PharmGKB
|RSID=rs10811661
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18544707
|Annotation=This variant is associated with improvement in beta-cell function for carriers of the protective genotype at CDKN2A/B after one year of troglitazone treatment and lifestyle modification.
|Drugs=troglitazone
|Drug Classes=
|Diseases=Diabetes Mellitus, Type 2
|Curation Level=Curated
|PharmGKB Accession ID=PA161748504
}}

{{PharmGKB
|RSID=rs10811661
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18162508; PubMed ID:18437351; PubMed ID:18461161
|Annotation=This variant has been reported to be significantly associated with type 2 diabetes in multiple ethnic population.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus, Type 2
|Curation Level=Curated
|PharmGKB Accession ID=PA161748506
}}

{{PharmGKB
|RSID=rs10811661
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:17463249
|Annotation=rs10811661 is associated with susceptibility to Type 2 Diabetes. The association has been noted in two case-control studies of UK subjects as well as in two other large case-control studies.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus, Type 2
|Curation Level=Curated
|PharmGKB Accession ID=PA162191337
}}

{{PharmGKB
|RSID=rs10811661
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:17463248
|Annotation=In a large Finnish case-control GWAS, rs10811661 was found to be associated with susceptibility to Type 2 Diabetes.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus, Type 2
|Curation Level=Curated
|PharmGKB Accession ID=PA162191355
}}

{{PharmGKB
|RSID=rs10811661
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:17463249; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes (Initial Sample Size: 1,924 cases, 2,938 controls; Replication Sample Size: 3,757 cases, 5,346 controls; Risk Allele: rs10811661-T).
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus; Diabetes Mellitus, Type 2
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356614
}}

{{PharmGKB
|RSID=rs10811661
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:17463248; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants (Initial Sample Size: 1,161 cases, 1,174 controls; Replication Sample Size: 1,215 cases, 1,258 controls; Risk Allele: rs10811661-T).
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus; Diabetes Mellitus, Type 2
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356610
}}

{{PharmGKB
|RSID=rs10811661
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:17463246; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels (Initial Sample Size: 1,464 cases, 1,467 controls; Replication Sample Size: 5,065 cases, 5,785 controls; Risk Allele: rs10811661-T).
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus; Diabetes Mellitus, Type 2
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356607
}}

{{PMID Auto
|PMID=21315566
|Title=Type 2 diabetes and polymorphisms on chromosome 9p21: A meta-analysis
}}

{{PMID Auto
|PMID=22052079
|Title=Association analysis of 31 common polymorphisms with type 2 diabetes and its related traits in Indian sib pairs
|OA=1
}}

{{PMID Auto
|PMID=22569928
|Title=Analysis of common type 2 diabetes mellitus genetic risk factors in new-onset diabetes after transplantation in kidney transplant patients medicated with tacrolimus
|OA=1
}}

{{PMID Auto
|PMID=22623142
|Title=Association between type 2 diabetes and rs10811661 polymorphism upstream of CDKN2A/B: a meta-analysis
}}

{{PMID Auto
|PMID=22643932
|Title=SNP in the genome-wide association study hotspot on chromosome 9p21 confers susceptibility to diabetic nephropathy in type 1 diabetes
}}

{{PMID Auto
|PMID=17786212
|Title=Heterogeneity in meta-analyses of genome-wide association investigations.
|OA=1
}}

{{PMID Auto
|PMID=17827400
|Title=Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies.
}}

{{PMID Auto
|PMID=17928989
|Title=Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population.
}}

{{PMID Auto
|PMID=18176561
|Title=The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm.
}}

{{PMID Auto
|PMID=18224312
|Title=Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.
|OA=1
}}

{{PMID Auto
|PMID=18224336
|Title=Haplotypic analysis of Wellcome Trust Case Control Consortium data.
|OA=1
}}

{{PMID Auto
|PMID=18264689
|Title=Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion.
}}

{{PMID Auto
|PMID=18423522
|Title=Estimating odds ratios in genome scans: an approximate conditional likelihood approach.
|OA=1
}}

{{PMID Auto
|PMID=18426861
|Title=Association analysis of type 2 diabetes Loci in type 1 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=18443202
|Title=Association analysis in african americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies.
|OA=1
}}

{{PMID Auto
|PMID=18469204
|Title=Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians.
|OA=1
}}

{{PMID Auto
|PMID=18533027
|Title=Worldwide population differentiation at disease-associated SNPs.
|OA=1
}}

{{PMID Auto
|PMID=18565990
|Title=Systematic biological prioritization after a genome-wide association study: an application to nicotine dependence.
|OA=1
}}

{{PMID Auto
|PMID=18591388
|Title=Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.
|OA=1
}}

{{PMID Auto
|PMID=18598350
|Title=Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk.
|OA=1
}}

{{PMID Auto
|PMID=18633108
|Title=Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population.
|OA=1
}}

{{PMID Auto
|PMID=18689899
|Title=Exchangeable models of complex inherited diseases.
|OA=1
}}

{{PMID Auto
|PMID=18694974
|Title=Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study.
|OA=1
}}

{{PMID Auto
|PMID=18782870
|Title=Clinical review: the genetics of type 2 diabetes: a realistic appraisal in 2008.
|OA=1
}}

{{PMID Auto
|PMID=18991055
|Title=Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean population.
}}

{{PMID Auto
|PMID=19002430
|Title=Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean population.
}}

{{PMID Auto
|PMID=19008344
|Title=Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians.
|OA=1
}}

{{PMID Auto
|PMID=19019192
|Title=Association of genetic variation on chromosome 9p21.3 and arterial stiffness.
}}

{{PMID Auto
|PMID=19020323
|Title=Genotype score in addition to common risk factors for prediction of type 2 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=19033589
|Title=Interaction between poor glycemic control and 9p21 locus on risk of coronary artery disease in type 2 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=19096518
|Title=Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.
|OA=1
}}

{{PMID Auto
|PMID=19207020
|Title=Meta-analysis in genome-wide association studies.
|OA=1
}}

{{PMID Auto
|PMID=19214202
|Title=Identification of a shared genetic susceptibility locus for coronary heart disease and periodontitis.
|OA=1
}}

{{PMID Auto
|PMID=19228808
|Title=Type 2 diabetes risk alleles are associated with reduced size at birth.
|OA=1
}}

{{PMID Auto
|PMID=19279076
|Title=Genetic predisposition, Western dietary pattern, and the risk of type 2 diabetes in men.
|OA=1
}}

{{PMID Auto
|PMID=19324937
|Title=Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults.
|OA=1
}}

{{PMID Auto
|PMID=19329499
|Title=A genetic variant on chromosome 9p21 and incident heart failure in the ARIC study.
|OA=1
}}

{{PMID Auto
|PMID=19341491
|Title=Genome-based prediction of common diseases: methodological considerations for future research.
|OA=1
}}

{{PMID Auto
|PMID=19343170
|Title=INK4/ARF transcript expression is associated with chromosome 9p21 variants linked to atherosclerosis.
|OA=1
}}

{{PMID Auto
|PMID=19401414
|Title=Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population.
|OA=1
}}

{{PMID Auto
|PMID=19455305
|Title=No association of multiple type 2 diabetes loci with type 1 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=19460916
|Title=Genetic architecture of type 2 diabetes: recent progress and clinical implications.
|OA=1
}}

{{PMID Auto
|PMID=19474294
|Title=Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.
|OA=1
}}

{{PMID Auto
|PMID=19502414
|Title=Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men.
|OA=1
}}

{{PMID Auto
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|Title=Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?
|OA=1
}}

{{PMID Auto
|PMID=19602701
|Title=Underlying genetic models of inheritance in established type 2 diabetes associations.
|OA=1
}}

{{PMID Auto
|PMID=19741467
|Title=Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea.
}}

{{PMID Auto
|PMID=19750184
|Title=Genome-wide association studies for atherosclerotic vascular disease and its risk factors.
|OA=1
}}

{{PMID Auto
|PMID=19862325
|Title=PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population.
|OA=1
}}

{{PMID Auto
|PMID=19931040
|Title=Simultaneous genotype calling and haplotype phasing improves genotype accuracy and reduces false-positive associations for genome-wide association studies.
|OA=1
}}

{{PMID Auto
|PMID=19956108
|Title=Analysis of 55 autoimmune disease and type II diabetes loci: further confirmation of chromosomes 4q27, 12q13.2 and 12q24.13 as type I diabetes loci, and support for a new locus, 12q13.3-q14.1.
|OA=1
}}

{{PMID Auto
|PMID=19956539
|Title=How many genetic variants remain to be discovered?
|OA=1
}}

{{PMID Auto
|PMID=20017978
|Title=Influence of control selection in genome-wide association studies: the example of diabetes in the Framingham Heart Study.
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}}

{{PMID Auto
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|Title=Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus.
|OA=1
}}

{{PMID Auto
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|Title=Association between type 2 diabetes loci and measures of fatness.
|OA=1
}}

{{PMID Auto
|PMID=20075150
|Title=Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study.
|OA=1
}}

{{PMID Auto
|PMID=20144327
|Title=A genomics study of type 2 diabetes mellitus in U.S. Air Force personnel.
|OA=1
}}

{{PMID Auto
|PMID=20161033
|Title=Personalized pharmacotherapy for Type 2 diabetes mellitus.
|OA=1
}}

{{PMID Auto
|PMID=20161779
|Title=Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort.
|OA=1
}}

{{PMID Auto
|PMID=20386740
|Title=Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression.
|OA=1
}}

{{PMID Auto
|PMID=20403154
|Title=Common genetic variants on chromosome 9p21 are associated with myocardial infarction and type 2 diabetes in an Italian population.
|OA=1
}}

{{PMID Auto
|PMID=20424228
|Title=Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians.
|OA=1
}}

{{PMID Auto
|PMID=20509872
|Title=Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population.
|OA=1
}}

{{PMID Auto
|PMID=20532014
|Title=The epidemiology of diabetes in Korea: from the economics to genetics.
|OA=1
}}

{{PMID Auto
|PMID=20550665
|Title=Association study of genetic variants in eight genes/loci with type 2 diabetes in a Han Chinese population.
|OA=1
}}

{{PMID Auto
|PMID=20712903
|Title=Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.
|OA=1
}}

{{PMID Auto
|PMID=21234743
|Title=Glucose tolerance, insulin sensitivity and insulin release in European non-diabetic carriers of a polymorphism upstream of CDKN2A and CDKN2B.
}}

{{PMID Auto
|PMID=21270277
|Title=The same chromosome 9p21.3 locus is associated with type 2 diabetes and coronary artery disease in a Chinese Han population.
|OA=1
}}

{{PMID Auto
|PMID=21278902
|Title=Genetic risk profiling for prediction of type 2 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=21283728
|Title=Genetic variants of diabetes risk and incident cardiovascular events in chronic coronary artery disease.
|OA=1
}}

{{PMID Auto
|PMID=21625859
|Title=Association between type 2 diabetes and CDKN2A/B: a meta-analysis study.
}}

{{PMID Auto
|PMID=22119613
|Title=Replication study of common variants in CDKAL1 and CDKN2A/2B genes associated with type 2 diabetes in Lebanese Arab population.
}}

{{PMID Auto
|PMID=22377712
|Title=Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography.
}}

{{PMID Auto GWAS
|PMID=22581228
|Trait=None
|Title=A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
|RiskAllele=
|Pval=0.000007
|OR=None
|ORtxt=None
|OA=1
}}

{{PMID Auto
|PMID=22676277
|Title=Vascular associated gene variants in patients with preeclampsia: results from the Danish National Birth Cohort
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10811661
|overall_frequency_n=19
|overall_frequency_d=126
|overall_frequency=0.150794
|n_genomes=11
|n_genomes_annotated=0
|n_haplomes=14
|n_articles=4
|n_articles_annotated=2
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23134948
|Title=Association between 9p21 genetic variants and mortality risk in a prospective cohort of patients with type 2 diabetes (ZODIAC-15)
|OA=1
}}

{{PMID Auto
|PMID=22923468
|Title=Contribution of common genetic variation to the risk of type 2 diabetes in the Mexican Mestizo population.
|OA=1
}}

{{PMID Auto
|PMID=23298195
|Title=Association study of genetic variants of 17 diabetes-related genes/loci and cardiovascular risk and diabetic nephropathy in the Chinese She population.
}}

{{PMID Auto
|PMID=23458876
|Title=ACE I/D and MTHFR C677T polymorphisms are significantly associated with type 2 diabetes in Arab ethnicity: a meta-analysis.
}}

{{PMID Auto
|PMID=23532257
|Title=Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4.
|OA=1
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}