{{Rsnum
|rsid=10818488
|Gene=TRAF1
|Chromosome=9
|position=120942809
|Orientation=plus
|GMAF=0.4908
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 26.2 | 53.8 | 20.0
| HCB | 24.4 | 51.1 | 24.4
| JPT | 18.2 | 52.3 | 29.5
| YRI | 44.4 | 50.8 | 4.8
| ASW | 0.0 | 0.0 | 0.0
| CHB | 24.4 | 51.1 | 24.4
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}[[rs10818488]], a SNP located in between the [[C5]] and [[TRAF1]] genes, was identified as the SNP from this region showing maximal association with [[rheumatoid arthritis]] in a study of ~2000 Dutch, Swedish, and American patients. This study also reported that this SNP was significantly (p = 0.008) associated with increased disease progression as determined by radiographic damage over time in [[rheumatoid arthritis]] patients. {{doi|10.1371/journal.pmed.0040278}}

The risk allele for [[rs10818488]] is the minor allele, (A). If (and as) reported from just the Dutch RA patients, the odds ratio associated with [[rs10818488(A;G)]] heterozygotes is 1.38 (CI 1.04-1.83, p = 0.027) and with [[rs10818488(A;A)]] homozygotes 2.06 (95% CI 1.42-2.98, p = 1.29E-3). Combining data from all 2,000 patients, the odds ratio associated with [[rs10818488]](A) is 1.26 (CI 1.15-1.37, pcombined = 1.40E-8) with a [http://www.snpedia.com/index.php?title=Glossary population attributable fraction] (or risk) of 6.1% (CI 4.0-8.5).

A study of RA patients from Crete also found that the [[rs10818488]](A) allele represented increased risk for [[rheumatoid arthritis]].{{PMID|18625278}}

A further study of 1,356 western Europeans confirmed the association between the [[rs10818488]](A) allele and [[rheumatoid arthritis]], finding that individuals with this allele have a 1.2x increased risk for the disease (CI: 1.04-1.5).{{PMID|18759306}}

{{PMID|18593758}} The [[rs10818488]](A) allele was associated with the susceptibility to rheumatoid factor-negative polyarthritis with an 11% increase in allele frequency (OR 1.54, CI: 1.09 to 2.18, p = 0.012) in a study of 338 Caucasian patients with juvenile idiopathic [[arthritis]].

Note that [[rs10818488]] is reported to be in complete (100%) linkage disequilibrium with [[rs2416808]], in other words, the genotype of one perfectly predicts the other.

{{PMID Auto
|PMID=19433411
|Title=The TRAF1-C5 region on chromosome 9q33 is associated with multiple autoimmune diseases
}}

{{PMID Auto
|PMID=19336421
|Title=Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese
}}

{{PMID Auto
|PMID=20205706
|Title=TRAF1/C5 polymorphism is not associated with increased mortality in rheumatoid arthritis; two large longitudinal studies
|OA=1
}}

{{PMID Auto
|PMID=20030635
|Title=The TRAF1/C5 locus confers risk for familial and severe alopecia areata
}}

{{PMID Auto
|PMID=21968398
|Title=TRAF1/C5, eNOS, C1q, but not STAT4 and PTPN22 gene polymorphisms are associated with genetic susceptibility to systemic lupus erythematosus in Turkey
}}

{{PMID Auto
|PMID=17880261
|Title=A candidate gene approach identifies the TRAF1/C5 region as a risk factor for rheumatoid arthritis.
|OA=1
}}

{{PMID Auto
|PMID=18432273
|Title=STAT4 but not TRAF1/C5 variants influence the risk of developing rheumatoid arthritis and systemic lupus erythematosus in Colombians.
}}

{{PMID Auto
|PMID=18434327
|Title=Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility.
|OA=1
}}

{{PMID Auto
|PMID=18648537
|Title=A large-scale rheumatoid arthritis genetic study identifies association at chromosome 9q33.2.
|OA=1
}}

{{PMID Auto
|PMID=18987647
|Title=Rheumatoid arthritis: a view of the current genetic landscape.
|OA=1
}}

{{PMID Auto
|PMID=19302705
|Title=Testing for the association of the KIAA1109/Tenr/IL2/IL21 gene region with rheumatoid arthritis in a European family-based study.
|OA=1
}}

{{PMID Auto
|PMID=19445664
|Title=Association of common polymorphisms in known susceptibility genes with rheumatoid arthritis in a Slovak population using osteoarthritis patients as controls.
|OA=1
}}

{{PMID Auto
|PMID=19674979
|Title=Overlap of disease susceptibility loci for rheumatoid arthritis and juvenile idiopathic arthritis.
|OA=1
}}

{{PMID Auto
|PMID=19918040
|Title=Lack of association between TRAF1/C5 gene polymorphisms and biopsy-proven giant cell arteritis.
}}

{{PMID Auto
|PMID=20353580
|Title=Evaluation of the rheumatoid arthritis susceptibility loci HLA-DRB1, PTPN22, OLIG3/TNFAIP3, STAT4 and TRAF1/C5 in an inception cohort.
|OA=1
}}

{{PMID Auto
|PMID=24234752
|Title=Association between polymorphism in TRAF1/C5 gene and risk of rheumatoid arthritis: a meta-analysis
}}

{{PMID Auto
|PMID=22820624
|Title=Associations between TNFSF4 and TRAF1-C5 gene polymorphisms and systemic lupus erythematosus: a meta-analysis.
}}

{{PMID Auto
|PMID=23321589
|Title=Association study of TRAF1/C5 polymorphism (rs10818488) with susceptibility to rheumatoid arthritis and systemic lupus erythematosus: a meta-analysis.
}}

{{PMID Auto
|PMID=23777930
|Title=Investigation of juvenile idiopathic arthritis susceptibility loci: results from a Greek population.
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}