{{Rsnum
|rsid=10821936
|Gene=ARID5B
|Chromosome=10
|position=63723577
|Orientation=plus
|GMAF=0.3108
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=131
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}
{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 9.7 | 42.5 | 47.8
| HCB | 7.3 | 45.3 | 47.4
| JPT | 12.4 | 44.2 | 43.4
| YRI | 7.9 | 23.8 | 68.3
| ASW | 1.8 | 33.3 | 64.9
| CHB | 7.3 | 45.3 | 47.4
| CHD | 12.0 | 50.0 | 38.0
| GIH | 41.6 | 44.6 | 13.9
| LWK | 2.7 | 30.0 | 67.3
| MEX | 5.2 | 62.1 | 32.8
| MKK | 5.2 | 29.9 | 64.9
| TSI | 14.7 | 51.0 | 34.3
| HapMapRevision=28
}}
{{PMID Auto GWAS
|PMID=19684603
|Trait=Acute lymphoblastic leukemia (childhood)
|Title=Germline genomic variants associated with childhood acute lymphoblastic leukemia
|RiskAllele=C
|Pval=1E-15
|OR=1.91
|ORtxt=[1.60-2.20]
|OA=1
}}

{{PharmGKB
|RSID=rs10821936
|Name_s=
|Gene_s=ARID5B
|Feature=Intron
|Evidence=PubMed ID:20054350
|Annotation=Phenotype: This SNP is associated with risk of childhood acute lymphoblastic leukemia in blacks and also with racial differences in frequency of the disease . The frequency of the risk allele, C, was significantly higher(0.33) in black children with ALL enrolled in St. Jude clinical trials than in controls of African ancestry (0.163 ASW,0.20 YRI). Risk Allelle: C allele. Study size/population/ethnicity: patients-93 black children with newly diagnosed ALL; controls- 112 unrelated subjects of African ancestry from the HapMap project(52 from American Southwest and 60 from Yoruba) . Significance metric(s): OR = 2.08; 95% CI = 1.32-3.27; p = 0.0015 . Type of association: CO; GN. The association of the C allele (one or two copies) with risk for the ALL subtype B-hyperdiploid ALL (compared to controls) had OR=6.62; 95% CI=2.0-21.9; p=0.0021 (n = 16).
|Drugs=
|Drug Classes=
|Diseases=Precursor Cell Lymphoblastic Leukemia-Lymphoma
|Curation Level=Curated
|PharmGKB Accession ID=PA165260369
}}

{{PharmGKB
|RSID=rs10821936
|Name_s=
|Gene_s=ARID5B
|Feature=Intron
|Evidence=PubMed ID:19684603
|Annotation=This SNP located in intron 3 of the ARID5B gene differed between pediatric acute lymphoblastic leukemia (ALL) and non-ALL groups (rs10821936, P = 1.4 x 10(-15), odds ratio (OR) = 1.91) and also distinguished B-hyperdiploid ALL from other subtypes (rs10821936, P = 1.62 x 10(-5), OR = 2.17). This SNP was in linkage disequilibrium with rs10994982 (r2 = 0.42, P < 1 10-10). The study found found that the same alleles of this ARID5B SNP rs10821936 that were associated with B-hyperdiploid ALL were also associated with greater methotrexate polyglutamate accumulation (P = 0.005).
|Drugs=methotrexate
|Drug Classes=
|Diseases=Precursor Cell Lymphoblastic Leukemia-Lymphoma
|Curation Level=Curated
|PharmGKB Accession ID=PA165106632
}}

{{omim
|id=613065
|rsnum=10821936
}}

{{PMID Auto
|PMID=22291082
|Title=ARID5B Genetic Polymorphisms Contribute to Racial Disparities in the Incidence and Treatment Outcome of Childhood Acute Lymphoblastic Leukemia
|OA=1
}}

{{PMID Auto
|PMID=22422485
|Title=Genetic variants modify susceptibility to leukemia in infants: A Children's Oncology Group report
|OA=1
}}

{{PMID Auto
|PMID=20460642
|Title=Replication analysis confirms the association of ARID5B with childhood B-cell acute lymphoblastic leukemia.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10821936
|overall_frequency_n=88
|overall_frequency_d=128
|overall_frequency=0.6875
|n_genomes=49
|n_genomes_annotated=0
|n_haplomes=76
|n_articles=2
|n_articles_annotated=1
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23608171
|Title=Association of three polymorphisms in ARID5B, IKZF1and CEBPE with the risk of childhood acute lymphoblastic leukemia in a Chinese population
}}

{{PMID Auto GWAS
  |PMID=23512250
  |Trait=Acute lymphoblastic leukemia (childhood)
  |Title=Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations.
  |RiskAllele=C
  |Pval=6E-46
  |OR=1.86
  |ORtxt=[1.71-2.03]
  |OA=1
}}

{{PMID Auto
|PMID=23692655
|Title=ARID5B and IKZF1 variants, selected demographic factors, and childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group
}}

{{PMID Auto
|PMID=24564228
|Title=ARID5B polymorphism confers an increased risk to acquire specific MLL rearrangements in early childhood leukemia
|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}