{{Rsnum
|rsid=10830963
|Gene=MTNR1B
|Chromosome=11
|position=92975544
|Orientation=plus
|GMAF=0.258
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=MTNR1B
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 44.6 | 50.8 | 4.6
| HCB | 32.8 | 55.5 | 11.7
| JPT | 33.0 | 44.6 | 22.3
| YRI | 91.7 | 8.3 | 0.0
| ASW | 91.2 | 8.8 | 0.0
| CHB | 32.8 | 55.5 | 11.7
| CHD | 26.4 | 51.9 | 21.7
| GIH | 0.0 | 0.0 | 0.0
| LWK | 99.1 | 0.9 | 0.0
| MEX | 55.2 | 37.9 | 6.9
| MKK | 94.2 | 5.8 | 0.0
| TSI | 56.4 | 35.6 | 7.9
| HapMapRevision=28
}}{{PMID|19241057}} rs10830963 was associated with an increased risk of [[type-2 diabetes]] in our Han Chinese cohort (OR 1.16, 95% CI 1.03-1.31, p = 0.015). As previously described, the risk variant was also associated with increased fasting plasma glucose, showing an increase of 0.068 mmol/l (95% CI 0.036-0.100, p = 4 x 10(-5)) per risk allele

{{PMID|19088850|OA=1
}} [[rs10830962]], [[rs4753426]], and [[rs10830963]] were significantly associated with higher fasting plasma glucose concentrations and reduced OGTT- and IVGTT-induced insulin release. [[rs3781638]] displayed significant association with lower fasting plasma glucose levels and increased OGTT-induced insulin release

{{PMID|19324940|OA=1
}} A study totaling 19,000+ Europeans concluded that [[rs10830963]] had the most influence of any [[MTNR1B]] gene SNP on the risk for [[type-2 diabetes]]. Specifically, the (G) allele increased the risk of isolated impaired fasting glycemia (OR=1.64, P=5.5x10(-11)) but not isolated impaired glucose tolerance.

{{PMID|21658282|OA=1
}} 900+ patients with [[gestational diabetes]] were studied, and the [[rs10830963]](G) SNP was postulated to perhaps be a causal SNP for the condition, with an odds ratio of ~1.3 - 1.4.

{{PMID Auto GWAS
|PMID=19060907
|Trait=Fasting plasma glucose
|Title=Variants in MTNR1B influence fasting glucose levels
|RiskAllele=G
|Pval=3E-50
|OR=0.07
|ORtxt=[0.06-0.08] mmol/l increase
|OA=1
}}

{{PMID Auto
|PMID=19651812
|Title=Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type-2 diabetes amongst Indian Asians and European whites
|OA=1
}}
{{PMID Auto
|PMID=19741166
|Title=Common Genetic Determinants of Glucose Homeostasis in Healthy Children: The European Youth Heart Study (EYHS)
|OA=1
}}

{{PharmGKB
|RSID=rs10830963
|Name_s=
|Gene_s=MTNR1B
|Feature=
|Evidence=PubMed ID:20081858
|Annotation=Phenotype 1: In a meta-analysis of 21 GWAS cohorts followed by analysis in additional individuals, this SNP was found to be associated with fasting glucose level. Study size: 112,844. Significance metric(s): p = 5.8 x 10(-175). Phenotype 2: In the same study, this SNP was found to be associated with HOMA-B (homeostasis model assessment of beta-cell function). Study size: 90,364. Significance metric(s): p = 2.7 x 10(-43). Study population/ethnicity: Non-diabetic Individuals of European descent. Type of association: CO;GN.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus, Type 2
|Curation Level=Curated
|PharmGKB Accession ID=PA165281934
}}

{{PMID Auto GWAS
|PMID=20081858
|Trait=Fasting glucose-related traits
|Title=New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
|RiskAllele=G
|Pval=0
|OR=None
|ORtxt=None
|OA=1
}}

{{PMID Auto
|PMID=20536959
|Title=Two susceptible diabetogenic variants near/in MTNR1B are associated with fasting plasma glucose in a Han Chinese cohort
}}
{{PMID Auto
|PMID=20802253
|Title=Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion
|OA=1
}}
{{PMID Auto
|PMID=20839289
|Title=Impact of repeated measures and sample selection on genome-wide association studies of fasting glucose
|OA=1
}}

{{PharmGKB
|RSID=rs10830963
|Name_s=
|Gene_s=MTNR1B
|Feature=
|Evidence=PubMed ID:19060907; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Variants in MTNR1B influence fasting glucose levels. (Initial Sample Size: 35,812 individuals; Replication Sample Size: NR); (Region: 11q21; Reported Gene(s): MTNR1B; Risk Allele: rs10830963-G); (p-value= 3E-50).This variant is associated with Fasting plasma glucose.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740301
}}
{{PMID Auto
|PMID=21036910
|Title=Association of a fasting glucose genetic risk score with subclinical atherosclerosis: The Atherosclerosis Risk in Communities (ARIC) Study
|OA=1
}}
{{PMID Auto
|PMID=21059861
|Title=Association of a melatonin receptor 1B (MTNR1B) gene variant with fasting glucose and HOMA-B in children and adolescents of high BMI-SDS groups
}}

{{omim
|id=613233
|rsnum=10830963
}}

{{PMID Auto
|PMID=21470412
|Title=A common polymorphism rs3781637 in MTNR1B is associated with type 2 diabetes and lipids levels in Han Chinese individuals
|OA=1
}}

{{PMID Auto
|PMID=21949744
|Title=Effects of 16 Genetic Variants on Fasting Glucose and Type 2 Diabetes in South Asians: ADCY5 and GLIS3 Variants May Predispose to Type 2 Diabetes
|OA=1
}}

{{PMID Auto
|PMID=22096510
|Title=Association of six single nucleotide polymorphisms with gestational diabetes mellitus in a chinese population
|OA=1
}}

{{PMID Auto
|PMID=22450346
|Title=The rs10830963 variant of melatonin receptor MTNR1B is associated with increased risk for gestational diabetes mellitus in a Greek population
}}

{{PMID Auto
|PMID=22508271
|Title=Fasting Glucose GWAS Candidate Region Analysis Across Ethnic Groups in the Multiethnic Study of Atherosclerosis (MESA).
|OA=1
}}

{{PMID Auto
|PMID=22698518
|Title=Melatonin pathway genes are associated with progressive subtypes and disability status in multiple sclerosis among Finnish patients
}}

{{PMID Auto
|PMID=22768333
|Title=Association of Genetic Variants of Melatonin Receptor 1B with Gestational Plasma Glucose Level and Risk of Glucose Intolerance in Pregnant Chinese Women
|OA=1
}}

{{PMID Auto GWAS
|PMID=22286219
|Trait=None
|Title=Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
|RiskAllele=
|Pval=3E-11
|OR=0.1400
|ORtxt=None
|OA=1
}}

{{PMID Auto
|PMID=22768041
|Title=Allele Summation of Diabetes Risk Genes Predicts Impaired Glucose Tolerance in Female and Obese Individuals
|OA=1
}}

{{PMID Auto
|PMID=19184136
|Title=Examination of association of genes in the serotonin system to autism.
|OA=1
}}

{{PMID Auto
|PMID=19324937
|Title=Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults.
|OA=1
}}

{{PMID Auto
|PMID=19455304
|Title=Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response.
|OA=1
}}

{{PMID Auto
|PMID=19502414
|Title=Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men.
|OA=1
}}

{{PMID Auto
|PMID=19533084
|Title=Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk.
|OA=1
}}

{{PMID Auto
|PMID=19822575
|Title=Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing.
|OA=1
}}

{{PMID Auto
|PMID=19937311
|Title=Common variants at the GCK, GCKR, G6PC2-ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations.
}}

{{PMID Auto
|PMID=20043853
|Title=Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus.
|OA=1
}}

{{PMID Auto
|PMID=20152958
|Title=A weighted false discovery rate control procedure reveals alleles at FOXA2 that influence fasting glucose levels.
|OA=1
}}

{{PMID Auto
|PMID=20398260
|Title=MTNR1B rs10830963 is associated with fasting plasma glucose, HbA1C and impaired beta-cell function in Chinese Hans from Shanghai.
|OA=1
}}

{{PMID Auto
|PMID=20628598
|Title=Common polymorphisms in MTNR1B, G6PC2 and GCK are associated with increased fasting plasma glucose and impaired beta-cell function in Chinese subjects.
|OA=1
}}

{{PMID Auto
|PMID=20664687
|Title=Single-nucleotide polymorphisms in chromosome 3p14.1- 3p14.2 are associated with susceptibility of type 2 diabetes with cataract.
|OA=1
}}

{{PMID Auto
|PMID=20668700
|Title=Effects of GCK, GCKR, G6PC2 and MTNR1B variants on glucose metabolism and insulin secretion.
|OA=1
}}

{{PMID Auto
|PMID=20712903
|Title=Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.
|OA=1
}}

{{PMID Auto
|PMID=20870969
|Title=Genetic predisposition to long-term nondiabetic deteriorations in glucose homeostasis: Ten-year follow-up of the GLACIER study.
|OA=1
}}

{{PMID Auto
|PMID=20959387
|Title=Association of rs10830963 and rs10830962 SNPs in the melatonin receptor (MTNR1B) gene among Han Chinese women with polycystic ovary syndrome.
}}

{{PMID Auto
|PMID=21278902
|Title=Genetic risk profiling for prediction of type 2 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=21366812
|Title=Relationship between MTNR1B (melatonin receptor 1B gene) polymorphism rs10830963 and glucose levels in overweight children and adolescents.
}}

{{PMID Auto
|PMID=21380592
|Title=No effect by the common gene variant rs10830963 of the melatonin receptor 1B on the association between sleep disturbances and type 2 diabetes: results from the Nord-Trondelag Health Study.
}}

{{PMID Auto
|PMID=21558052
|Title=A low frequency variant within the GWAS locus of MTNR1B affects fasting glucose concentrations: Genetic risk is modulated by obesity.
|OA=1
}}

{{PMID Auto
|PMID=21711391
|Title=Association and evolutionary studies of the melatonin receptor 1B gene (MTNR1B) in the self-contained population of Sorbs from Germany.
}}

{{PMID Auto
|PMID=22377712
|Title=Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography.
}}

{{PMID Auto GWAS
|PMID=22581228
|Trait=None
|Title=A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
|RiskAllele=
|Pval=4E-105
|OR=None
|ORtxt=None
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10830963
|overall_frequency_n=26
|overall_frequency_d=128
|overall_frequency=0.203125
|n_genomes=18
|n_genomes_annotated=0
|n_haplomes=19
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=22759724
|Title=Polymorphisms in the melatonin receptor 1B gene and the risk of delirium
}}

{{PMID Auto
|PMID=23029294
|Title=Meta-analysis of the relationship between common type 2 diabetes risk gene variants with gestational diabetes mellitus
|OA=1
}}

{{PMID Auto
|PMID=23690305
|Title=Genetic variants and the risk of gestational diabetes mellitus: a systematic review
}}

{{PMID Auto
|PMID=23840762
|Title=Large Scale Meta-Analyses of Fasting Plasma Glucose Raising Variants in GCK, GCKR, MTNR1B and G6PC2 and Their Impacts on Type 2 Diabetes Mellitus Risk
|OA=1
}}

{{PMID Auto
|PMID=24005634
|Title=[Involvement of melatonin MT2 receptor mutants in type 2 diabetes development]
}}

{{PMID Auto
|PMID=24157813
|Title=Association between Genetic Variations in MTNR1A and MTNR1B Genes and Gestational Diabetes Mellitus in Han Chinese Women
}}

{{PMID Auto
|PMID=23092954
|Title=SHAVE: shrinkage estimator measured for multiple visits increases power in GWAS of quantitative traits.
|OA=1
}}

{{PMID Auto
|PMID=23456907
|Title=Maternal genotype and gestational diabetes.
}}

{{PMID Auto
|PMID=23462794
|Title=Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets.
|OA=1
}}

{{PMID Auto
|PMID=23611530
|Title=Genetics of melatonin receptor type 2 is associated with left ventricular function in hypertensive patients treated according to guidelines.
}}

{{PMID Auto
|PMID=25132852
|Title=MTNR1B Genetic Variability Is Associated with Gestational Diabetes in Czech Women
}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}