{{Rsnum
|rsid=10835638
|Gene=FSHB
|Chromosome=11
|position=30230805
|Orientation=plus
|GMAF=0.08632
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=FSHB
}}[[rs10835638]], a SNP located in the (upstream) regulatory region of the follicle stimulating hormone [[FSHB]] gene, may influence hormone levels.

A quantitative genetic association study of 550+ healthy Estonian men (average age 19) found that [[rs10835638]] was significantly associated with serum FSH level (analysis of variance: F = 13.0, P = 0.0016, df = 1; regression testing for a linear trend: P = 0.0003). 

Subjects with the (G;G) genotype had higher FSH levels (3.37 +/- 1.79 IU/l, n = 423) compared with (G;T) heterozygotes (2.84 +/- 1.54 IU/l, n = 125) (p = 0.0005) or (T;T) homozygotes (2.02 +/- 0.81 IU/L, n = 6) (P = 0.031). [[rs10835638]] was also associated with significant reduction in free testosterone index and testes volume, but increased semen volume, sex hormone-binding globulin, serum testosterone and estradiol LH and inhibin-B levels did not differ significantly between groups.{{PMID|18567894|OA=1
}}
{{PMID Auto
|PMID=19897680
|Title=Increased Prevalance of the -211 T Allele of Follicle Stimulating Hormone (FSH) {beta} Subunit Promoter Polymorphism and Lower Serum FSH in Infertile Men
|OA=1
}}

{{PMID Auto
|PMID=22791757
|Title=Combined Effects of the Variants FSHB -211G/T and FSHR 2039A&gt;G on Male Reproductive Parameters
}}

{{PMID Auto
|PMID=23118424
|Title=Effects of the FSH-β-Subunit Promoter Polymorphism -211G-&gt;T on the Hypothalamic-Pituitary-Ovarian Axis in Normally Cycling Women Indicate a Gender-Specific Regulation of Gonadotropin Secretion
}}

{{PMID Auto
|PMID=25052309
|Title=The FSHB -211G&gt;T variant attenuates serum FSH levels in the supraphysiological gonadotropin setting of Klinefelter syndrome
}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}