{{Rsnum
|rsid=10838738
|Gene=MTCH2
|Chromosome=11
|position=47641497
|Orientation=plus
|GMAF=0.2837
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=MTCH2
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 40.7 | 46.0 | 13.3
| HCB | 49.6 | 39.4 | 10.9
| JPT | 45.1 | 42.5 | 12.4
| YRI | 87.8 | 12.2 | 0.0
| ASW | 86.0 | 14.0 | 0.0
| CHB | 49.6 | 39.4 | 10.9
| CHD | 49.5 | 41.3 | 9.2
| GIH | 54.5 | 35.6 | 9.9
| LWK | 85.5 | 14.5 | 0.0
| MEX | 32.8 | 48.3 | 19.0
| MKK | 61.5 | 35.9 | 2.6
| TSI | 51.0 | 37.3 | 11.8
| HapMapRevision=28
}}
{{PMID Auto GWAS
|PMID=19079261
|Trait=Body mass index
|Title=Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
|RiskAllele=G
|Pval=5E-9
|OR=0.07
|ORtxt=[0.01-0.13] kg/m2 increase
|OA=1
}}

{{PharmGKB
|RSID=rs10838738
|Name_s=
|Gene_s=MTCH2
|Feature=
|Evidence=PubMed ID:19079261; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. (Initial Sample Size: 32,387 individuals; Replication Sample Size: 59,092 individuals); (Region: 11p11.2; Reported Gene(s): MTCH2; Risk Allele: rs10838738-G); (p-value= 0.000000005).This variant is associated with Body mass index.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740177
}}

{{omim
|desc=MITOCHONDRIAL CARRIER HOMOLOG 2; MTCH2
|id=613221
|rsnum=10838738
}}

{{PMID Auto
|PMID=21248185
|Title=Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals
}}

{{PMID Auto
|PMID=21796141
|Title=Computed tomography analysis of the association between the SH2B1 rs7498665 single-nucleotide polymorphism and visceral fat area
}}

{{PMID Auto
|PMID=21912638
|Title=Studies of metabolic phenotypic correlates of 15 obesity associated gene variants
|OA=1
}}

{{PMID Auto
|PMID=22083549
|Title=Study of eight GWAS-identified common variants for association with obesity-related indices in Chinese children at puberty
}}

{{PMID|19474294|OA=1
}} Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.

{{PMID|19478790|OA=1
}} The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI.

{{PMID|19526209|OA=1
}} Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?

{{PMID|19553259|OA=1
}} Common body mass index-associated variants confer risk of extreme obesity.

{{PMID|19910641|OA=1
}} Obesity genotype score and cardiovascular risk in women with type 2 diabetes mellitus.

{{PMID|19910938}} Novel obesity risk loci do not determine distribution of body fat depots: a whole-body MRI/MRS study.

{{PMID|20127379|OA=1
}} From monogenic to polygenic obesity: recent advances.

{{PMID|20712903|OA=1
}} Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.

{{PMID|20824172|OA=1
}} Physical activity attenuates the genetic predisposition to obesity in 20,000 men and women from EPIC-Norfolk prospective population study.

{{PMID|21283731|OA=1
}} FTO and MC4R gene variants are associated with obesity in polycystic ovary syndrome.

{{PMID|22179955|OA=1
}} Genetic predictors of weight loss and weight regain after intensive lifestyle modification, metformin treatment, or standard care in the Diabetes Prevention Program.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10838738
|overall_frequency_n=32
|overall_frequency_d=128
|overall_frequency=0.25
|n_genomes=23
|n_genomes_annotated=0
|n_haplomes=26
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

[[Measures of Obesity]]

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}