{{Rsnum
|rsid=10865331
|Chromosome=2
|position=62324337
|Orientation=plus
|GMAF=0.4201
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 6.2 | 45.1 | 48.7
| HCB | 18.2 | 49.6 | 32.1
| JPT | 4.4 | 45.1 | 50.4
| YRI | 31.3 | 49.0 | 19.7
| ASW | 36.8 | 52.6 | 10.5
| CHB | 18.2 | 49.6 | 32.1
| CHD | 16.5 | 52.3 | 31.2
| GIH | 17.8 | 47.5 | 34.7
| LWK | 24.5 | 53.6 | 21.8
| MEX | 10.3 | 44.8 | 44.8
| MKK | 41.0 | 41.7 | 17.3
| TSI | 18.6 | 51.0 | 30.4
| HapMapRevision=28
}}

[[rs10865331]] is a SNP in chromosomal region 2p15.

After initial GWAS reports linked this SNP to [[ankylosing spondylitis]] (AS), a follow-up study in 456 Spanish patients replicated the association between the [[rs10865331]](A) allele and higher risk for AS (p = 0.039). 

In a 2010 report, the AA genotype was associated with 1.3x odds of [[ankylosing spondylitis]], and the GG genotype with 0.8x odds, compared to the AG genotype. {{PMID|20062062|OA=1
}}

{{PMID Auto GWAS
|PMID=20062062
|Trait=Ankylosing spondylitis
|Title=Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci
|RiskAllele=A
|Pval=2E-19
|OR=1.27
|ORtxt=[1.18-1.37]
|OA=1
}}

{{omim
|id=106300
|rsnum=10865331
}}

{{PMID Auto GWAS
|PMID=21743469
|Trait=None
|Title=Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.
|RiskAllele=A
|Pval=7E-34
|OR=None
|ORtxt=None
|OA=1
}}

{{PMID Auto
|PMID=22138694
|Title=A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis
}}

{{PMID Auto
|PMID=20810504
|Title=Association of the intergenic single-nucleotide polymorphism rs10865331 (2p15) with ankylosing spondylitis in a Spanish population.
}}

{{PMID Auto
|PMID=21041274
|Title=Genetic studies of ankylosing spondylitis in Koreans confirm associations with ERAP1 and 2p15 reported in white patients.
}}

{{PMID Auto
|PMID=21068102
|Title=Association of STAT3 and TNFRSF1A with ankylosing spondylitis in Han Chinese.
}}

{{PMID Auto GWAS
  |PMID=23128233
  |Trait=Crohn's disease
  |Title=Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
  |RiskAllele=A
  |Pval=1E-9
  |OR=1.10
  |ORtxt=[1.062-1.134]
  |OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}