{{Rsnum
|rsid=10871454
|Gene=STX4
|Chromosome=16
|position=31036758
|Orientation=plus
|GMAF=0.4669
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=STX4
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 39.8 | 40.7 | 19.5
| HCB | 0.0 | 8.8 | 91.2
| JPT | 0.0 | 19.5 | 80.5
| YRI | 93.9 | 6.1 | 0.0
| ASW | 84.2 | 10.5 | 5.3
| CHB | 0.0 | 8.8 | 91.2
| CHD | 0.9 | 15.6 | 83.5
| GIH | 65.3 | 32.7 | 2.0
| LWK | 86.4 | 13.6 | 0.0
| MEX | 27.6 | 50.0 | 22.4
| MKK | 67.3 | 30.8 | 1.9
| TSI | 28.4 | 50.0 | 21.6
| HapMapRevision=28
}}
{{PMID Auto GWAS
|PMID=18535201
|Trait=Warfarin maintenance dose
|Title=A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose
|RiskAllele=
|Pval=5.0000000000000003E-34
|OR=NR
|ORtxt=NR
|OA=1
}}

{{PharmGKB
|RSID=rs10871454
|Name_s=STX4
|Gene_s=STX4
|Feature=
|Evidence=PubMed ID:18535201
|Annotation=In a GWAS study, this SNP accounted for ~25% of the variance in log-transformed stabilized warfarin dose, and was in perfect linkage disequilibrium with rs9923231 (VKORC1:-1639).
|Drugs=warfarin
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA161748416
}}

{{PMID Auto
|PMID=21063236
|Title=Dependency of phenprocoumon dosage on polymorphisms in the VKORC1, CYP2C9, and CYP4F2 genes
}}

{{PMID Auto
|PMID=22321278
|Title=[Impact of CYP2C9 and VKORC1 polymorphism on warfarin response during initiation of therapy]
}}

{{PMID Auto
|PMID=19578179
|Title=A genome-wide association study of acenocoumarol maintenance dosage.
}}

{{PMID Auto
|PMID=22178823
|Title=[Distribution of variant alleles association with warfarin pharmacokinetics and pharmacodynamics in the Han population in China].
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10871454
|overall_frequency_n=44
|overall_frequency_d=128
|overall_frequency=0.34375
|n_genomes=25
|n_genomes_annotated=0
|n_haplomes=40
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}