{{Rsnum
|rsid=10876432
|Gene=SP7
|Chromosome=12
|position=53338107
|Orientation=plus
|GMAF=0.2833
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=SP7
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 50.4 | 38.1 | 11.5
| HCB | 100.0 | 0.0 | 0.0
| JPT | 100.0 | 0.0 | 0.0
| YRI | 30.6 | 48.3 | 21.1
| ASW | 36.8 | 52.6 | 10.5
| CHB | 100.0 | 0.0 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 88.1 | 11.9 | 0.0
| LWK | 29.1 | 54.5 | 16.4
| MEX | 67.2 | 27.6 | 5.2
| MKK | 50.6 | 43.6 | 5.8
| TSI | 51.5 | 40.6 | 7.9
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=19079262
|Trait=Bone mineral density (spine)
|Title=New sequence variants associated with bone mineral density
|RiskAllele=A
|Pval=1E-7
|OR=0.08
|ORtxt=[0.05-0.11] SD decrease
}}

{{PharmGKB
|RSID=rs10876432
|Name_s=
|Gene_s=SP7
|Feature=
|Evidence=PubMed ID:19079262; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: New sequence variants associated with bone mineral density. (Initial Sample Size: 6,865 individuals; Replication Sample Size: 8,510 individuals); (Region: 12q13.13; Reported Gene(s): OSX; Risk Allele: rs10876432-A); (p-value= 0.0000001).This variant is associated with Bone mineral density (spine).
|Drugs=
|Drug Classes=
|Diseases=Bone Diseases; Bone Diseases, Metabolic
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740143
}}

{{omim
|id=606257
|rsnum=10876432
}}

{{PMID Auto
|PMID=19181680
|Title=Common variants in the region around Osterix are associated with bone mineral density and growth in childhood.
|OA=1
}}

{{PMID Auto
|PMID=20534768
|Title=OPG and RANK polymorphisms are both associated with cortical bone mineral density: findings from a metaanalysis of the Avon longitudinal study of parents and children and gothenburg osteoporosis and obesity determinants cohorts.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10876432
|overall_frequency_n=71
|overall_frequency_d=96
|overall_frequency=0.739583
|n_genomes=37
|n_genomes_annotated=0
|n_haplomes=59
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}