{{Rsnum
|rsid=10883365
|Chromosome=10
|position=101287764
|Orientation=plus
|GMAF=0.4752
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=131
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}
{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 31.9 | 45.1 | 23.0
| HCB | 29.2 | 48.9 | 21.9
| JPT | 26.5 | 50.4 | 23.0
| YRI | 29.9 | 51.0 | 19.0
| ASW | 19.3 | 52.6 | 28.1
| CHB | 29.2 | 48.9 | 21.9
| CHD | 27.5 | 46.8 | 25.7
| GIH | 35.6 | 49.5 | 14.9
| LWK | 26.4 | 46.4 | 27.3
| MEX | 37.9 | 48.3 | 13.8
| MKK | 17.3 | 55.8 | 26.9
| TSI | 22.5 | 50.0 | 27.5
| HapMapRevision=28
}}[[rs10883365]] has been reported in a large study to be associated with [[Crohn's disease]].

The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 1.2 (CI 1.03-1.39), and for homozygotes, 1.62 (CI 1.37-1.92). {{PMID|17554300|OA=1
}}

{{PMID|18936107}} The association between [[rs10883365]] and [[Crohn's disease]] was replicated in a Japanese population.

{{GWAS Summary
|SNP=rs10883365
|PubMedID=17554261
|Condition=Crohn's disease
|Gene=NKX2-3
|Risk Allele=
|pValue=4.00E-010
|OR=1.18
|95CI=1.05-1.32
|OA=1
}}
{{PMID Auto
|PMID=19174780
|Title=Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort
}}

{{omim
|desc=INFLAMMATORY BOWEL DISEASE 20; IBD20
|id=612288
|rsnum=10883365
}}

{{PharmGKB
|RSID=rs10883365
|Name_s=
|Gene_s=NKX2-3
|Feature=
|Evidence=PubMed ID:17554261; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility (Initial Sample Size: 1,748 cases, 2,938 controls; Replication Sample Size: 1,182 cases, 2,024 controls). This variant is associated with Crohn's disease.
|Drugs=
|Drug Classes=
|Diseases=Crohn Disease
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356575
}}

{{PMID Auto
|PMID=19953089
|Title=Differences in genetic background between active smokers, passive smokers, and non-smokers with Crohn's disease
}}

{{PharmGKB
|RSID=rs10883365
|Name_s=
|Gene_s=NKX2-3
|Feature=
|Evidence=PubMed ID:17554300; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls (Initial Sample Size: 1,748 cases, 2,938 controls; Replication Sample Size: (see Parkes 2007); Risk Allele: rs10883365-G). This variant is associated with crohn's disease.
|Drugs=
|Drug Classes=
|Diseases=Crohn Disease
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356636
}}

{{PMID Auto
|PMID=21514341
|Title=Increased expression of NKX2.3 mRNA transcribed from the risk haplotype for ulcerative colitis in the involved colonic mucosa
}}

{{PMID|18224312|OA=1
}} Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.

{{PMID|18438406|OA=1
}} Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.

{{PMID|18533027|OA=1
}} Worldwide population differentiation at disease-associated SNPs.

{{PMID|18853133|OA=1
}} Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.

{{PMID|19140132|OA=1
}} Unbiased estimation of odds ratios: combining genomewide association scans with replication studies.

{{PMID|19683022}} Lack of association of NKX2-3, IRGM, and ATG16L1 inflammatory bowel disease susceptibility variants with celiac disease.

{{PMID|21049557|OA=1
}} NKX2-3 and IRGM variants are associated with disease susceptibility to IBD in Eastern European patients.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10883365
|overall_frequency_n=68
|overall_frequency_d=128
|overall_frequency=0.53125
|n_genomes=44
|n_genomes_annotated=0
|n_haplomes=61
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}