{{Rsnum
|rsid=10889353
|Gene=DOCK7
|Chromosome=1
|position=62652525
|Orientation=plus
|GMAF=0.2897
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=DOCK7
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 43.4 | 46.0 | 10.6
| HCB | 68.6 | 27.7 | 3.6
| JPT | 77.9 | 21.2 | 0.9
| YRI | 27.9 | 51.7 | 20.4
| ASW | 35.1 | 49.1 | 15.8
| CHB | 68.6 | 27.7 | 3.6
| CHD | 65.1 | 32.1 | 2.8
| GIH | 39.6 | 40.6 | 19.8
| LWK | 43.6 | 42.7 | 13.6
| MEX | 51.7 | 29.3 | 19.0
| MKK | 43.6 | 44.2 | 12.2
| TSI | 46.1 | 42.2 | 11.8
| HapMapRevision=28
}}
{{PMID Auto GWAS
|PMID=19060911
|Trait=Cholesterol, total
|Title=Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
|RiskAllele=C
|Pval=4E-12
|OR=0.08
|ORtxt=[NR] SD decrease
|OA=1
}}
{{PMID Auto GWAS
|PMID=19060906
|Trait=Triglycerides
|Title=Common variants at 30 loci contribute to polygenic dyslipidemia
|RiskAllele=C
|Pval=3E-7
|OR=0.05
|ORtxt=[0.01-0.09] SD decrease
|OA=1
}}

{{PharmGKB
|RSID=rs10889353
|Name_s=
|Gene_s=DOCK7
|Feature=
|Evidence=PubMed ID:19060911; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. (Initial Sample Size: 17,797 individuals; Replication Sample Size: NR); (Region: 1p31.3; Reported Gene(s): DOCK7; Risk Allele: rs10889353-C); (p-value= 0.000008).This variant is associated with LDL cholesterol.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740220
}}

{{PharmGKB
|RSID=rs10889353
|Name_s=
|Gene_s=DOCK7
|Feature=
|Evidence=PubMed ID:19060906; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Common variants at 30 loci contribute to polygenic dyslipidemia. (Initial Sample Size: 19,840 individuals; Replication Sample Size: Up to 20,623 individuals); (Region: 1p31.3; Reported Gene(s): ANGPTL3; Risk Allele: rs10889353-C); (p-value= 0.0000003).This variant is associated with Triglycerides.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740260
}}

{{PharmGKB
|RSID=rs10889353
|Name_s=
|Gene_s=DOCK7
|Feature=
|Evidence=PubMed ID:19060911; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. (Initial Sample Size: 22,562 individuals; Replication Sample Size: NR); (Region: 1p31.3; Reported Gene(s): DOCK7; Risk Allele: rs10889353-C); (p-value= 0.000000000004).This variant is associated with Cholesterol, total.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740200
}}

{{PMID|19802338|OA=1
}} Genetic loci associated with plasma concentration of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, apolipoprotein A1, and Apolipoprotein B among 6382 white women in genome-wide analysis with replication.

{{PMID|20160193|OA=1
}} Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples.

{{PMID|20502693|OA=1
}} Genetics and beyond--the transcriptome of human monocytes and disease susceptibility.

{{PMID|20832063}} Exploring genetic determinants of plasma total cholesterol levels and their predictive value in a longitudinal study.

{{PMID|21347282|OA=1
}} Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10889353
|overall_frequency_n=43
|overall_frequency_d=128
|overall_frequency=0.335938
|n_genomes=31
|n_genomes_annotated=0
|n_haplomes=38
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Illumina Human 1M}}