{{Rsnum
|rsid=10895068
|Gene=PGR
|Chromosome=11
|position=101129483
|Orientation=minus
|GMAF=0.02066
|Gene_s=LOC101054525,PGR
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}[[rs10895068]], also known as +331G/A, is a SNP in the progesterone receptor [[PGR]] gene.

A study of 1,664 postmenopausal breast cancer cases and 2,391 controls led to two conclusions. First, women with at least one [[rs10895068]](A) allele had a 1.3x (CI: 1.04-1.65) increased risk of developing [[breast cancer]]. Second, such carriers were at 2.57x (CI: 1.64-4.02) increased risk for [[breast cancer]] if they were never postmenopausal hormone users.{{PMID|19462450|OA=1
}}

2013 meta-analysis suggested association of weak effect with female reproductive (breast, endometrial and ovarian) cancer for A allele (A: OR = 1.063, 95% CI = 1.001-1.129; AA+AG: OR = 1.067, 95% CI = 1.002-1.136). A 2014 meta-analysis that looked only for association with ovarian cancer specifically found no significant association between rs10895068 and ovarian cancer - despite the study title claiming otherwise.


{{PMID|24197980}} Progesterone receptor PROGINS and +331G/A polymorphisms confer susceptibility to ovarian cancer: a meta-analysis based on 17 studies.

{{PMID|23349706}} Association of +331G/A PgR polymorphism with susceptibility to female reproductive cancer: evidence from a meta-analysis.

{{PMID Auto
|PMID=20076999
|Title=No association between a progesterone receptor gene promoter polymorphism (+331G&gt;A) and breast cancer risk in Caucasian women: evidence from a literature-based meta-analysis
}}

{{PMID Auto
|PMID=20586553
|Title=Polymorphisms in ESR1, ESR2 and HSD17B1 genes are associated with fertility status in endometriosis
}}
{{PMID Auto
|PMID=21086036
|Title=Association of progesterone receptor polymorphism with idiopathic recurrent pregnancy loss in Taiwanese Han population
|OA=1
}}
{{PMID Auto
|PMID=21148628
|Title=Progesterone receptor gene variants and risk of endometrial cancer
|OA=1
}}

{{ population diversity
| geno1 = (A;G)
| geno2 = (G;G)
| geno3 = 
| CEU | 12.4 | 87.6 | 0
| CHB | 0 | 0 | 0
| JPT | 0 | 0 | 0
| YRI | 0 | 0 | 0
}}

{{PMID Auto
|PMID=22121098
|Title=Worldwide distribution of allelic variation at the progesterone receptor locus and the incidence of female reproductive cancers
}}

{{PMID Auto
|PMID=16614108
|Title=Association of the progesterone receptor gene with breast cancer risk: a single-nucleotide polymorphism tagging approach.
}}

{{PMID Auto
|PMID=16985038
|Title=PGR +331 A/G and increased risk of epithelial ovarian cancer.
}}

{{PMID Auto
|PMID=17592773
|Title=Progesterone receptor polymorphisms and risk of breast cancer: results from two Australian breast cancer studies.
}}

{{PMID Auto
|PMID=18219286
|Title=Progesterone receptor variation and risk of ovarian cancer is limited to the invasive endometrioid subtype: results from the Ovarian Cancer Association Consortium pooled analysis.
|OA=1
}}

{{PMID Auto
|PMID=18592033
|Title=Sex steroid-related candidate genes in psychiatric disorders.
|OA=1
}}

{{PMID Auto
|PMID=18628428
|Title=Polymorphisms in genes involved in sex hormone metabolism, estrogen plus progestin hormone therapy use, and risk of postmenopausal breast cancer.
|OA=1
}}

{{PMID Auto
|PMID=18805939
|Title=Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.
|OA=1
}}

{{PMID Auto
|PMID=19382201
|Title=Association of the progesterone receptor gene with endometrial cancer risk in a Chinese population.
|OA=1
}}

{{PMID Auto
|PMID=19555469
|Title=A prospective study of androgen levels, hormone-related genes and risk of rheumatoid arthritis.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | Illumina Human 1M}}