{{Rsnum
|rsid=10896449
|Chromosome=11
|position=69227200
|Orientation=plus
|GMAF=0.4063
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 23.6 | 46.4 | 30.0
| HCB | 81.8 | 17.5 | 0.7
| JPT | 91.2 | 8.8 | 0.0
| YRI | 8.2 | 43.8 | 47.9
| ASW | 10.5 | 33.3 | 56.1
| CHB | 81.8 | 17.5 | 0.7
| CHD | 87.0 | 12.0 | 0.9
| GIH | 56.0 | 37.0 | 7.0
| LWK | 12.7 | 44.5 | 42.7
| MEX | 45.6 | 43.9 | 10.5
| MKK | 17.5 | 48.1 | 34.4
| TSI | 25.5 | 41.2 | 33.3
| HapMapRevision=28
}}[http://www.nature.com/ng/journal/vaop/ncurrent/abs/ng.91.html nature] identifies [[rs10486567]] [[rs10993994]] [[rs10896449]] in [[prostate cancer]]

{{ neighbor
| rsid = 7931342
| distance = 170
}}

{{GWAS Summary
|SNP=rs10896449
|PubMedID=18264096
|Condition=Prostate cancer (aggressive)
|Gene=Intergenic
|Risk Allele=G
|pValue=2.00E-009
|OR=1.1
|95CI=0.98-1.23
}}

{{PMID Auto
|PMID=19505914
|Title=Two independent prostate cancer risk-associated Loci at 11q13
|OA=1
}}

{{omim
|desc=PROSTATE CANCER, HEREDITARY, 14; HPC14
|id=611958
|rsnum=10896449
}}
{{PMID Auto
|PMID=19902474
|Title=Replication of prostate cancer risk loci on 8q24, 11q13, 17q12, 19q33, and Xp11 in African Americans
}}

{{PharmGKB
|RSID=rs10896449
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18264096; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Multiple loci identified in a genome-wide association study of prostate cancer (Initial Sample Size: 1,172 cases, 1,157 controls; Replication Sample Size: 3,941 cases, 3,964 controls; Risk Allele: rs10896449-G).
|Drugs=
|Drug Classes=
|Diseases=Prostatic Neoplasms
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356742
}}

{{PMID Auto
|PMID=21531787
|Title=Fine mapping of a region of chromosome 11q13 reveals multiple independent loci associated with risk of prostate cancer
|OA=1
}}

{{PMID Auto
|PMID=22459122
|Title=Interactions Between Genome-wide Significant Genetic Variants and Circulating Concentrations of Insulin-like Growth Factor 1, Sex Hormones, and Binding Proteins in Relation to Prostate Cancer Risk in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium
|OA=1
}}

{{PMID Auto
|PMID=18708398
|Title=Multiple novel prostate cancer predisposition loci confirmed by an international study: the PRACTICAL Consortium.
|OA=1
}}

{{PMID Auto
|PMID=18794092
|Title=Association of prostate cancer risk variants with clinicopathologic characteristics of the disease.
|OA=1
}}

{{PMID Auto
|PMID=19366831
|Title=Analysis of recently identified prostate cancer susceptibility loci in a population-based study: associations with family history and clinical features.
|OA=1
}}

{{PMID Auto
|PMID=19434657
|Title=Individual and cumulative effect of prostate cancer risk-associated variants on clinicopathologic variables in 5,895 prostate cancer patients.
|OA=1
}}

{{PMID Auto
|PMID=19549807
|Title=Prostate cancer risk associated loci in African Americans.
|OA=1
}}

{{PMID Auto
|PMID=19567509
|Title=Genetic variants and prostate cancer risk: candidate replication and exploration of viral restriction genes.
|OA=1
}}

{{PMID Auto
|PMID=20039378
|Title=Estimation of genotype relative risks from pedigree data by retrospective likelihoods.
|OA=1
}}

{{PMID Auto
|PMID=20569440
|Title=Alterations in LMTK2, MSMB and HNF1B gene expression are associated with the development of prostate cancer.
|OA=1
}}

{{PMID Auto
|PMID=20690139
|Title=Meta-analysis of genome-wide and replication association studies on prostate cancer.
}}

{{PMID Auto
|PMID=21390317
|Title=Characterizing associations and SNP-environment interactions for GWAS-identified prostate cancer risk markers--results from BPC3.
|OA=1
}}

{{PMID Auto
|PMID=21520160
|Title=Prostate cancer risk variants are not associated with disease progression.
}}

{{PMID Auto
|PMID=22468268
|Title=Comprehensive resequence analysis of a 123-kb region of chromosome 11q13 associated with prostate cancer.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10896449
|overall_frequency_n=56
|overall_frequency_d=126
|overall_frequency=0.444444
|n_genomes=37
|n_genomes_annotated=0
|n_haplomes=52
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23405784
|Title=[Susceptibility to prostate cancer in Han Chinese: single nucleotide polymorphism analysis of 1 667 cases]
}}

{{PMID Auto
|PMID=23573233
|Title=Characterization of SNPs Associated with Prostate Cancer in Men of Ashkenazic Descent from the Set of GWAS Identified SNPs: Impact of Cancer Family History and Cumulative SNP Risk Prediction
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}