{{Rsnum
|rsid=10903129
|Gene=TMEM57
|Chromosome=1
|position=25442446
|Orientation=plus
|GMAF=0.4959
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=TMEM57
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 18.6 | 54.0 | 27.4
| HCB | 48.2 | 47.4 | 4.4
| JPT | 51.3 | 38.9 | 9.7
| YRI | 8.2 | 32.7 | 59.2
| ASW | 7.0 | 42.1 | 50.9
| CHB | 48.2 | 47.4 | 4.4
| CHD | 48.6 | 41.3 | 10.1
| GIH | 34.7 | 51.5 | 13.9
| LWK | 5.6 | 35.2 | 59.3
| MEX | 35.1 | 49.1 | 15.8
| MKK | 5.1 | 30.8 | 64.1
| TSI | 25.5 | 49.0 | 25.5
| HapMapRevision=28
}}per the [http://blog.23andme.com/2008/12/08/new-papers-from-nature-genetics-yield-a-bounty-of-cholesterol-snps/ 23andMe blog], the minor allele of this SNP (A) was associated with decreased [[cholesterol]] and [[triglycerides]]
 
{| border="1"
|-
!SNP
!Rarer allele
!LDL
!HDL
!TG
|-
| [[rs6544713]] || T || + || ||
|-
| [[rs2650000]] || A || + || ||
|-
| [[rs471364]] || C || || - ||
|-
| [[rs1800961]] || T || || - ||
|-
| [[rs7679]] || C || || - || +
|-
| [[rs2967605]] || T || || - ||
|-
| [[rs2409722]] || T || || || -
|-
| [[rs10903129]] || A || - || - || -
|-
| [[rs6756629]] || A || - || + || -
|-
| [[rs12670798]] || C || + || + || +
|-
| [[rs7395662]] || A || - || + || +
|-
| [[rs174570]] || T || - || - || +
|-
| [[rs2271293]] || A || - || + || -
|-
| [[rs2624265]] || C || || || +
|-
| [[rs2167079]] || T || || + ||
|-
| [[rs9891572]] || T || || + ||
|-
| [[rs4844614]] || T || + || ||
|-
| [[rs5031002]] || G || + || ||
|-
|}

{{PMID Auto GWAS
|PMID=19060911
|Trait=Cholesterol, total
|Title=Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
|RiskAllele=G
|Pval=5E-10
|OR=0.06
|ORtxt=[NR] SD increase
|OA=1
}}

{{PharmGKB
|RSID=rs10903129
|Name_s=
|Gene_s=TMEM57
|Feature=
|Evidence=PubMed ID:19060911; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. (Initial Sample Size: 22,562 individuals; Replication Sample Size: NR); (Region: 1p36.11; Reported Gene(s): TMEM57; Risk Allele: rs10903129-G); (p-value= 0.0000000005).This variant is associated with Cholesterol, total.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740188
}}

{{PMID Auto GWAS
|PMID=21700265
|Trait=None
|Title=Complement receptor 1 gene variants are associated with erythrocyte sedimentation rate.
|RiskAllele=
|Pval=5E-13
|OR=0.1000
|ORtxt=[NR] unit decrease
|OA=1
}}

{{PMID Auto
|PMID=20084173
|Title=Magnitude of stratification in human populations and impacts on genome wide association studies.
|OA=1
}}

{{PMID Auto
|PMID=21304891
|Title=A study of CNVs as trait-associated polymorphisms and as expression quantitative trait loci.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10903129
|overall_frequency_n=76
|overall_frequency_d=128
|overall_frequency=0.59375
|n_genomes=45
|n_genomes_annotated=0
|n_haplomes=66
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23856853
|Title=Association of a complement receptor 1 gene variant with baseline erythrocyte sedimentation rate levels in patients starting anti-TNF therapy in a UK rheumatoid arthritis cohort: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}