{{Rsnum
|rsid=10913469
|Gene=SEC16B
|Chromosome=1
|position=177944384
|Orientation=plus
|GMAF=0.2346
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=SEC16B
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 5.4 | 40.2 | 54.5
| HCB | 5.9 | 34.6 | 59.6
| JPT | 8.0 | 31.9 | 60.2
| YRI | 10.9 | 42.9 | 46.3
| ASW | 8.8 | 42.1 | 49.1
| CHB | 5.9 | 34.6 | 59.6
| CHD | 4.6 | 27.5 | 67.9
| GIH | 5.0 | 35.6 | 59.4
| LWK | 14.5 | 47.3 | 38.2
| MEX | 0.0 | 19.3 | 80.7
| MKK | 14.7 | 43.6 | 41.7
| TSI | 1.0 | 35.3 | 63.7
| HapMapRevision=28
}}
{{PMID Auto GWAS
|PMID=19079260
|Trait=Body mass index
|Title=Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
|RiskAllele=C
|Pval=6E-8
|OR=3.36
|ORtxt=[2.14-4.58] % SD
}}

{{PMID Auto
|PMID=19851340
|Title=Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population
}}

{{PharmGKB
|RSID=rs10913469
|Name_s=
|Gene_s=SEC16B
|Feature=
|Evidence=PubMed ID:19079260; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. (Initial Sample Size: 80,969 individuals; Replication Sample Size: 11,036 individuals); (Region: 1q25.2; Reported Gene(s): SEC16B, RASAL2; Risk Allele: rs10913469-C); (p-value= 0.00000001).This variant is associated with Weight.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740163
}}

{{PMID Auto
|PMID=20061430
|Title=Obesity Susceptibility Genetic Variants Identified from Recent Genome-Wide Association Studies: Implications in a Chinese Population
}}

{{PharmGKB
|RSID=rs10913469
|Name_s=
|Gene_s=SEC16B
|Feature=
|Evidence=PubMed ID:19079260; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. (Initial Sample Size: 80,969 individuals; Replication Sample Size: 11,036 individuals); (Region: 1q25.2; Reported Gene(s): SEC16B, RASAL2; Risk Allele: rs10913469-C); (p-value= 0.00000006).This variant is associated with Body mass index.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740144
}}

{{PMID Auto
|PMID=21796141
|Title=Computed tomography analysis of the association between the SH2B1 rs7498665 single-nucleotide polymorphism and visceral fat area
}}

{{PMID Auto
|PMID=21912638
|Title=Studies of metabolic phenotypic correlates of 15 obesity associated gene variants
|OA=1
}}

{{PMID|19478790|OA=1
}} The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI.

{{PMID|19553259|OA=1
}} Common body mass index-associated variants confer risk of extreme obesity.

{{PMID|20127379|OA=1
}} From monogenic to polygenic obesity: recent advances.

{{PMID|20712903|OA=1
}} Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.

{{PMID|20824172|OA=1
}} Physical activity attenuates the genetic predisposition to obesity in 20,000 men and women from EPIC-Norfolk prospective population study.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10913469
|overall_frequency_n=24
|overall_frequency_d=128
|overall_frequency=0.1875
|n_genomes=18
|n_genomes_annotated=0
|n_haplomes=20
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23424664
|Title=Study of 11 BMI-associated loci identified in GWAS for associations with central obesity in the Chinese children
|OA=1
}}

{{PMID Auto
|PMID=23935507
|Title=Gene × physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry
|OA=1
}}

{{PMID Auto
|PMID=24269186
|Title=An obesity genetic risk score is associated with metabolic syndrome in Chinese children
}}

{{PMID Auto
|PMID=23408508
|Title=Obesity-susceptibility loci and the tails of the pediatric BMI distribution
|OA=1
}}

{{PMID Auto
|PMID=23121087
|Title=Sex-dependent associations of genetic variants identified by GWAS with indices of adiposity and obesity risk in a Chinese children population.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}