{{Rsnum
|rsid=10918594
|Gene=NOS1AP
|Chromosome=1
|position=162060898
|Orientation=plus
|GMAF=0.4288
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
}}[[rs10918594]], a SNP near the [[NOS1AP]] gene encoding the nitric oxide synthase I protein, accounts for some of the variation seen in abnormal heart rhythms, in particular, the QT interval. Based on studies totaling ~4,000 individuals of Caucasian ancestry, homozygotes for one allele have shorter QT intervals, while homozygotes for the other allele have a longer QT interval. {{PMID|16648850}}

A follow-up study determined that one [[rs10918594(G)]] allele was associated with a 3.6-ms (CI: 2.7 - 4.4ms, p=6.9x10(-17)) increase in QT interval duration, and two (G) alleles had twice that increase. No increase in risk for sudden death due to a cardiac problem was associated with this SNP, though. {{PMID|17576865}}

{{PMID|18235038}} [[rs10494366]] minor homozygotes had a 9.3 msec longer QT interval compared to major homozygotes (p=5.7x10(-5)); [[rs10918594]] minor homozygotes had a 12.5 msec longer QT interval compared to major homozygotes (p=1.5x10(-6)). Restricting analyses to the diabetic EAs strengthened the effect despite the reduction in sample size (11.3 msec difference, p=5.1x10(-5); 13.9 msec difference, p=1.6x10(-6), respectively).
{{PMID Auto
|PMID=19247217
|Title=Calcium channel blockers, NOS1AP, and heart-rate-corrected QT prolongation
}}

{{omim
|desc=QT INTERVAL, VARIATION IN
|id=610141
|rsnum=10918594
}}

{{PharmGKB
|RSID=rs10918594
|Name_s=
|Gene_s=NOS1AP
|Feature=
|Evidence=PubMed ID:19247217
|Annotation=In a study of 112 patients taking verapamil, patients with genotype GG of this SNP showed significantly more QTc prolongation than users with the CC genotype. Genotype at this SNP was not significantly associated with QTc prolongation in the 44 patients studied who were taking isradipine.
|Drugs=isradipine; verapamil
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA163993333
}}

{{PMID Auto
|PMID=20215044
|Title=Relationship of Common Candidate Gene Variants to Electrocardiographic T-Wave Peak to T-Wave End Interval and T-Wave Morphology Parameters
|OA=1
}}

{{PMID Auto
|PMID=19019189
|Title=Common candidate gene variants are associated with QT interval duration in the general population.
|OA=1
}}

{{PMID Auto
|PMID=21959512
|Title=Association of the rs10918594 of nitric oxide synthase 1 adaptor protein (NOS1AP) polymorphisms with the graft function after kidney transplantation.
}}

{{PMID Auto
|PMID=22019493
|Title=Cardiac levels of NOS1AP RNA from right ventricular tissue recovered during lead extraction.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10918594
|overall_frequency_n=59
|overall_frequency_d=126
|overall_frequency=0.468254
|n_genomes=40
|n_genomes_annotated=0
|n_haplomes=49
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}